Pheochromocytoma causes: Difference between revisions
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* Familial causes can be sub-divided into two major clusters based on [[genes]] causing the disease.<ref name="pmid23933153">{{cite journal| author=King KS, Pacak K| title=Familial pheochromocytomas and paragangliomas. | journal=Mol Cell Endocrinol | year= 2014 | volume= 386 | issue= 1-2 | pages= 92-100 | pmid=23933153 | doi=10.1016/j.mce.2013.07.032 | pmc=3917973 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23933153 }}</ref> | * Familial causes can be sub-divided into two major clusters based on [[genes]] causing the disease.<ref name="pmid23933153">{{cite journal| author=King KS, Pacak K| title=Familial pheochromocytomas and paragangliomas. | journal=Mol Cell Endocrinol | year= 2014 | volume= 386 | issue= 1-2 | pages= 92-100 | pmid=23933153 | doi=10.1016/j.mce.2013.07.032 | pmc=3917973 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23933153 }}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
! colspan="2"align="center" style="background:#4479BA; color: #FFFFFF;" + |Familial pheochromocytoma | ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Familial pheochromocytoma | ||
|- | |- | ||
!align="center" style="background:#4479BA; color: #FFFFFF;" + |Cluster 1 (Noradrenergic) | !align="center" style="background:#4479BA; color: #FFFFFF;" + |Cluster 1 (Noradrenergic) | ||
Revision as of 14:21, 13 October 2017
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Pheochromocytoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Pheochromocytoma causes On the Web |
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American Roentgen Ray Society Images of Pheochromocytoma causes |
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Risk calculators and risk factors for Pheochromocytoma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2] Mohammed Abdelwahed M.D[3]
Overview
Pheochromocytoma arises from chromaffin cells, found in adrenal medulla which secrete adrenaline, noradrenaline, and dopamine. Majority of pheochromocytomas are sporadic (50-60 percent), others are familial. Familial forms can be sub-divided into two major clusters based on genes causing the disease. Cluster 1 tumors are noradrenergic and cluster 2 tumors are adrenergic. Familial pheochromocytoma may be caused by a mutation of either SDHD, VHL, SDHB, RET, NF1 genes.
Causes
- Majority of pheochromocytomas are sporadic (50-60 percent), others are familial.
- Approximately 10 percent of pheochromocytoma tumors are malignant. Common sites of spread are the base of skull, head, and neck.
- Familial causes can be sub-divided into two major clusters based on genes causing the disease.[1]
| Familial pheochromocytoma | |
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| Cluster 1 (Noradrenergic) | Cluster 2 (Adrenergic) |
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References
- ↑ King KS, Pacak K (2014). "Familial pheochromocytomas and paragangliomas". Mol Cell Endocrinol. 386 (1–2): 92–100. doi:10.1016/j.mce.2013.07.032. PMC 3917973. PMID 23933153.