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*Peptic ulcer disease is caused by gastrinomas [[Zollinger-Ellison syndrome|(Zollinger-Ellison syndrome]])caused by a mutation in MEN gene present on chromosome 11q13. | *Peptic ulcer disease is caused by gastrinomas [[Zollinger-Ellison syndrome|(Zollinger-Ellison syndrome]])caused by a mutation in MEN gene present on chromosome 11q13. | ||
===Causes by organ | ===Causes by organ sys=== | ||
* For an example of the causes by organ system table in a causes microchapter, click [[Jaundice causes#Causes by Organ System|here]]. | * For an example of the causes by organ system table in a causes microchapter, click [[Jaundice causes#Causes by Organ System|here]]. | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Dermatologic''' | | '''Dermatologic''' | ||
| bgcolor="Beige" | Rosacea,Chronic idiopathic urticaria ,Psoriasis vulgaris ,Behcet's disease ,Alopecia areata,Sweet's syndrome <ref name="pmid25045884">{{cite journal| author=Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E et al.| title=Helicobacter pylori infection and skin disorders. | journal=Hong Kong Med J | year= 2014 | volume= 20 | issue= 4 | pages= 317-24 | pmid=25045884 | doi=10.12809/hkmj134174 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25045884 }} </ref> | | bgcolor="Beige" | [[Rosacea]],Chronic idiopathic [[urticaria]] ,[[Psoriasis|Psoriasis vulgaris]] ,[[Behçet's disease|Behcet's disease]] ,[[Alopecia areata]],[[Sweet's syndrome]] <ref name="pmid25045884">{{cite journal| author=Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E et al.| title=Helicobacter pylori infection and skin disorders. | journal=Hong Kong Med J | year= 2014 | volume= 20 | issue= 4 | pages= 317-24 | pmid=25045884 | doi=10.12809/hkmj134174 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25045884 }} </ref> | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
| bgcolor="Beige" | serotonin reuptake -NSAIDs,Clopidogrel,spironolactone,sirolimus,bisphosphonates (when combined with NSAIDs),mycophenolate mofetil,spironolactone ,chemotherapy (hepatic infusion of 5 - fluorouracil ,selective serotonin reuptake inhibitor | | bgcolor="Beige" | serotonin reuptake -[[NSAIDs]],[[Clopidogrel]],[[spironolactone]],[[sirolimus]],[[Bisphosphonate|bisphosphonates]] (when combined with NSAIDs),[[Mycophenolate sodium|mycophenolate mofetil]],[[spironolactone]] ,chemotherapy (hepatic infusion of [[5 - fluorouracil]] ,[[Selective serotonin reuptake inhibitor|selective serotonin reuptake inhibitor]] | ||
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| '''Endocrine''' | | '''Endocrine''' | ||
| bgcolor="Beige" | Diabetes mellitus | | bgcolor="Beige" | [[Diabetes mellitus]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Environmental''' | | '''Environmental''' | ||
| bgcolor="Beige" |smoking, excess alcohol consumption, caffeine ,more common in patients with Diabetes Mellitus ,hypertension ,metabolic syndrome<ref name="pmid28834889">{{cite journal| author=Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW et al.| title=The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 34 | pages= e7828 | pmid=28834889 | doi=10.1097/MD.0000000000007828 | pmc=5572011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28834889 }} </ref> | | bgcolor="Beige" |smoking, excess alcohol consumption, caffeine ,more common in patients with [[Diabetes mellitus|Diabetes Mellitus]] ,hypertension ,metabolic syndrome<ref name="pmid28834889">{{cite journal| author=Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW et al.| title=The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 34 | pages= e7828 | pmid=28834889 | doi=10.1097/MD.0000000000007828 | pmc=5572011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28834889 }} </ref> | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Gastroenterologic''' | | '''Gastroenterologic''' | ||
| bgcolor="Beige" | Crohn’s disease of the stomach or duodenum, Eosinophilic gastroduodenitis | | bgcolor="Beige" | [[Crohn's disease|Crohn’s disease]] of the stomach or duodenum, [[Eosinophilic gastroduodenitis]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Genetic''' | | '''Genetic''' | ||
| bgcolor="Beige" |Zollinger -Ellison syndrome associated with MEN TYPE 1 syndrome caused by mutation in MEN gene present on chromosome 11q 13 | | bgcolor="Beige" |[[Zollinger -Ellison syndrome]] associated with [[MEN TYPE 1]] syndrome caused by mutation in MEN gene present on chromosome 11q 13 | ||
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| '''Infectious Disease''' | | '''Infectious Disease''' | ||
| bgcolor="Beige" | Helicobacter pylori (60% gastric and 50-75% duodenal ulcers ), Herpes simplex virus type 1, Cytomegalovirus, Helicobacter | | bgcolor="Beige" | [[Helicobacter pylori]] (60% gastric and 50-75% duodenal ulcers ), [[Herpes simplex virus type 1]], [[Cytomegalovirus]], [[Helicobacter heilmanni]]<nowiki/>i, [[Tuberculosis]], [[syphilis]], and [[mucormycosis]] | ||
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| '''Oncologic''' | | '''Oncologic''' | ||
| bgcolor="Beige" | Non-beta cell tumor , carcinoid syndrome , gastrinomas | | bgcolor="Beige" | [[Non-beta cell tumor]] ,[[carcinoid syndrome]] , [[gastrinomas]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
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| '''Psychiatric''' | | '''Psychiatric''' | ||
| bgcolor="Beige" | severe stress, depressed mood, suicidal ideation and psychological counseling <ref name="pmid28834889">{{cite journal| author=Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW et al.| title=The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 34 | pages= e7828 | pmid=28834889 | doi=10.1097/MD.0000000000007828 | pmc=5572011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28834889 }} </ref> | | bgcolor="Beige" | severe [[stress]], depressed mood, suicidal ideation and psychological counseling <ref name="pmid28834889">{{cite journal| author=Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW et al.| title=The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 34 | pages= e7828 | pmid=28834889 | doi=10.1097/MD.0000000000007828 | pmc=5572011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28834889 }} </ref> | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Pulmonary''' | | '''Pulmonary''' | ||
| bgcolor="Beige" | COPD,Sarcoidosis | | bgcolor="Beige" | [[COPD]],[[Sarcoidosis]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Renal/Electrolyte''' | | '''Renal/Electrolyte''' | ||
| bgcolor="Beige" | Hypercalcemia | | bgcolor="Beige" | [[Hypercalcemia]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Rheumatology/Immunology/Allergy''' | | '''Rheumatology/Immunology/Allergy''' | ||
| bgcolor="Beige" | Fibromyalgia<ref name="pmid28384332">Wang KA, Wang JC, Lin CL, Tseng CH (2017) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=28384332 Association between fibromyalgia syndrome and peptic ulcer disease development.] ''PLoS One'' 12 (4):e0175370. [http://dx.doi.org/10.1371/journal.pone.0175370 DOI:10.1371/journal.pone.0175370] PMID: [https://pubmed.gov/28384332 28384332]</ref> | | bgcolor="Beige" | [[Fibromyalgia]]<ref name="pmid28384332">Wang KA, Wang JC, Lin CL, Tseng CH (2017) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=28384332 Association between fibromyalgia syndrome and peptic ulcer disease development.] ''PLoS One'' 12 (4):e0175370. [http://dx.doi.org/10.1371/journal.pone.0175370 DOI:10.1371/journal.pone.0175370] PMID: [https://pubmed.gov/28384332 28384332]</ref> | ||
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| '''Trauma''' | | '''Trauma''' | ||
| bgcolor="Beige" | Cushing ulcers | | bgcolor="Beige" | [[Cushing ulcers]] | ||
|- | |- | ||
Revision as of 18:34, 13 October 2017
Common causes [1]
- Helicobacter pylori (60% gastric and 50-75% duodenal ulcers )
- Drugs-NSAIDs including aspirin[2]
Less common causes of peptic ulcer disease
- Hormonal or mediator-induced including secondary acid hypersecretory states
- Antral g - cell hyperfunction
- Post-surgical -Antral exclusion and post gastric bypass surgery
- Tumors-cancers and lymphoma
- Cameron ulcer (gastric ulcer where a hiatus hernia passes through the diaphragmatic hiatus)
- True idiopathic ulcer.
Rare causes of peptic ulcer disease [1]
- Crohn’s disease of the stomach or duodenum
- Eosinophilic gastroduodenitis
- Systemic mastocytosis
- Radiation damage
- Viral infections (eg cytomegalovirus or herpes simplex infection, in particular in immunocompromised patients)
- Colonisation of stomach with H heilmanii
- Severe systemic disease
Genetic causes -[3]
- Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.
Causes by organ sys
- For an example of the causes by organ system table in a causes microchapter, click here.
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | Rosacea,Chronic idiopathic urticaria ,Psoriasis vulgaris ,Behcet's disease ,Alopecia areata,Sweet's syndrome [4] |
| Drug Side Effect | serotonin reuptake -NSAIDs,Clopidogrel,spironolactone,sirolimus,bisphosphonates (when combined with NSAIDs),mycophenolate mofetil,spironolactone ,chemotherapy (hepatic infusion of 5 - fluorouracil ,selective serotonin reuptake inhibitor |
| Ear Nose Throat | No underlying causes |
| Endocrine | Diabetes mellitus |
| Environmental | smoking, excess alcohol consumption, caffeine ,more common in patients with Diabetes Mellitus ,hypertension ,metabolic syndrome[5] |
| Gastroenterologic | Crohn’s disease of the stomach or duodenum, Eosinophilic gastroduodenitis |
| Genetic | Zollinger -Ellison syndrome associated with MEN TYPE 1 syndrome caused by mutation in MEN gene present on chromosome 11q 13 |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | Helicobacter pylori (60% gastric and 50-75% duodenal ulcers ), Herpes simplex virus type 1, Cytomegalovirus, Helicobacter heilmannii, Tuberculosis, syphilis, and mucormycosis |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Non-beta cell tumor ,carcinoid syndrome , gastrinomas |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | severe stress, depressed mood, suicidal ideation and psychological counseling [5] |
| Pulmonary | COPD,Sarcoidosis |
| Renal/Electrolyte | Hypercalcemia |
| Rheumatology/Immunology/Allergy | Fibromyalgia[6] |
| Sexual | No underlying causes |
| Trauma | Cushing ulcers |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in alphabetical order[edit | edit source] List the causes of the disease in alphabetical order.
Cause 1 Alopecia areata Cause 2 Behcet's disease Cause 3 caffeine Cause 4 Cause 5 Cause 6 Cause 7 Cause 8 Cause 9 Cause 10
- ↑ 1.0 1.1 Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
- ↑ Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
- ↑ Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
- ↑ Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E; et al. (2014). "Helicobacter pylori infection and skin disorders". Hong Kong Med J. 20 (4): 317–24. doi:10.12809/hkmj134174. PMID 25045884.
- ↑ 5.0 5.1 Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW; et al. (2017). "The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article". Medicine (Baltimore). 96 (34): e7828. doi:10.1097/MD.0000000000007828. PMC 5572011. PMID 28834889.
- ↑ Wang KA, Wang JC, Lin CL, Tseng CH (2017) Association between fibromyalgia syndrome and peptic ulcer disease development. PLoS One 12 (4):e0175370. DOI:10.1371/journal.pone.0175370 PMID: 28384332