Peptic ulcer causes: Difference between revisions

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*[[Zollinger-Ellison syndrome]]
*[[Zollinger-Ellison syndrome]]
{{EndMultiCol}}
{{EndMultiCol}}
Common causes <ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340  }} </ref>
*[[Helicobacter pylori|Helicobacter pylori (]]60% gastric and 50-75% duodenal ulcers )
*Drugs-[[Non-steroidal anti-inflammatory drug|NSAIDs]] including [[aspirin]]<ref name="pmid11960062">{{cite journal |vauthors=Hirschowitz BI, Lanas A |title=Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse |journal=J. Clin. Gastroenterol. |volume=34 |issue=5 |pages=523–8 |year=2002 |pmid=11960062 |doi= |url=}}</ref>
Less common causes of peptic ulcer disease
*Hormonal or mediator-induced including secondary acid hypersecretory states
**[[Gastrinomas]]
** [[Mastocytosis|Systemic mastocytosis]]
** [[Carcinoid syndrome]]
** [[Myeloproliferative disease|Myeloproliferative disorder]] 
*Antral g - cell hyperfunction
*Post-surgical -Antral exclusion and post gastric bypass surgery
*Tumors-cancers and [[lymphoma]]
*Cameron [[ulcer]] (gastric ulcer where a [[hiatus hernia]] passes through the [[diaphragmatic hiatus]])
*True idiopathic ulcer.
'''Rare causes of peptic ulcer disease''' <ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340  }} </ref>
* [[Crohn's disease|Crohn’s disease]] of the stomach or duodenum
* [[Eosinophilic gastroduodenitis]]
* Systemic mastocytosis
* Radiation damage
* Viral infections (eg [[cytomegalovirus]] or [[Herpes simplex|herpes simplex infection]], in particular in immunocompromised patients)
*Colonisation of stomach with H heilmanii
* Severe systemic disease


'''Genetic causes''' -<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377  }} </ref>
*Peptic ulcer disease is caused by gastrinomas [[Zollinger-Ellison syndrome|(Zollinger-Ellison syndrome]])caused by a mutation in MEN gene present on chromosome 11q13.
===Causes by organ sys===
* For an example of the causes by organ system table in a causes microchapter, click [[Jaundice causes#Causes by Organ System|here]].
{| style="width:80%; height:100px" border="1"
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
|-
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Dental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| bgcolor="Beige" | [[Rosacea]],Chronic idiopathic [[urticaria]] ,[[Psoriasis|Psoriasis vulgaris]] ,[[Behçet's disease|Behcet's disease]] ,[[Alopecia areata]],[[Sweet's syndrome]] <ref name="pmid25045884">{{cite journal| author=Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E et al.| title=Helicobacter pylori infection and skin disorders. | journal=Hong Kong Med J | year= 2014 | volume= 20 | issue= 4 | pages= 317-24 | pmid=25045884 | doi=10.12809/hkmj134174 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25045884  }} </ref>
|-
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| bgcolor="Beige" | serotonin reuptake -[[NSAIDs]],[[Clopidogrel]],[[spironolactone]],[[sirolimus]],[[Bisphosphonate|bisphosphonates]] (when combined with NSAIDs),[[Mycophenolate sodium|mycophenolate mofetil]],[[spironolactone]] ,chemotherapy (hepatic infusion of [[5 - fluorouracil]] ,[[Selective serotonin reuptake inhibitor|selective serotonin reuptake  inhibitor]]
|-
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| bgcolor="Beige" | [[Diabetes mellitus]]
|-
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| bgcolor="Beige" |smoking, excess alcohol consumption, caffeine  ,more common in patients with [[Diabetes mellitus|Diabetes Mellitus]] ,hypertension ,metabolic syndrome<ref name="pmid28834889">{{cite journal| author=Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW et al.| title=The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 34 | pages= e7828 | pmid=28834889 | doi=10.1097/MD.0000000000007828 | pmc=5572011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28834889  }} </ref>
|-
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| bgcolor="Beige" | [[Crohn's disease|Crohn’s disease]] of the stomach or duodenum, [[Eosinophilic gastroduodenitis]]
|-
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| bgcolor="Beige" |[[Zollinger -Ellison syndrome]] associated with [[MEN TYPE 1]] syndrome caused by mutation in MEN gene present on chromosome 11q 13
|-
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| bgcolor="Beige" | [[Helicobacter pylori]] (60% gastric and 50-75% duodenal ulcers ), [[Herpes simplex virus type 1]], [[Cytomegalovirus]], [[Helicobacter heilmanni]]<nowiki/>i, [[Tuberculosis]], [[syphilis]], and [[mucormycosis]]
|-
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| bgcolor="Beige" | [[Non-beta cell tumor]] ,[[carcinoid syndrome]] , [[gastrinomas]]
|-
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| bgcolor="Beige" | severe [[stress]], depressed mood, suicidal ideation and psychological counseling <ref name="pmid28834889">{{cite journal| author=Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW et al.| title=The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 34 | pages= e7828 | pmid=28834889 | doi=10.1097/MD.0000000000007828 | pmc=5572011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28834889  }} </ref>
|-
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| bgcolor="Beige" | [[COPD]],[[Sarcoidosis]]
|-
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| bgcolor="Beige" | [[Hypercalcemia]]
|-
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| bgcolor="Beige" | [[Fibromyalgia]]<ref name="pmid28384332">Wang KA, Wang JC, Lin CL, Tseng CH (2017) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=28384332 Association between fibromyalgia syndrome and peptic ulcer disease development.] ''PLoS One'' 12 (4):e0175370. [http://dx.doi.org/10.1371/journal.pone.0175370 DOI:10.1371/journal.pone.0175370] PMID: [https://pubmed.gov/28384332 28384332]</ref>
|-
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| bgcolor="Beige" | [[Cushing ulcers]]
|-
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| bgcolor="Beige" | No underlying causes
|-
|}
Causes in alphabetical order[edit | edit source]
List the causes of the disease in alphabetical order.
Cause 1 Alopecia areata
Cause 2 Behcet's disease
Cause 3  caffeine
Cause 4
Cause 5
Cause 6
Cause 7
Cause 8
Cause 9
Cause 10
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 19:52, 17 October 2017

Peptic ulcer Microchapters

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Case #1

2017 ACG Guidelines for Peptic Ulcer Disease

Guidelines for the Indications to Test for, and to Treat, H. pylori Infection

Guidelines for First line Treatment Strategies of Peptic Ulcer Disease for Providers in North America

Guidlines for factors that predict the successful eradication when treating H. pylori infection

Guidelines to document H. pylori antimicrobial resistance in the North America

Guidelines for evaluation and testing of H. pylori antibiotic resistance

Guidelines for when to test for treatment success after H. pylori eradication therapy

Guidelines for penicillin allergy in patients with H. pylori infection

Guidelines for the salvage therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Common causes of peptic ulcer disease include Helicobacter pylori infection and NSAID use. Less common causes of peptic ulcer disease include Crohn's disease, Zollinger-Ellison syndrome, Cushing and Curling ulcers, Carcinoid tumors, and carcinoid syndrome.

Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Aceclofenac, Acemetacin, Alendronate, Artemether and lumefantrin, Aspirin, Azapropazone, Benoxaprofen, Bisphosphonates, Carbinoxamine, Celecoxib, Clopidogrel, Dexamethasone, Diclofenac, Diflunisal, Ethanol, ethanolamine oleate, Etidronic acid, Etodolac, Etoricoxib, Febuxostat, Fenbufen, Fenoprofen, Flurbiprofen, Glucocorticoids, Hydrocortisone, Ibuprofen, Indomethacin, Ketoprofen, Laxative abuse, Mefenamic acid, Meloxicam, Mepenzolate bromide, Methylprednisolone, Nabumetone, Naproxen, Naproxen and esomeprazole magnesium, Niacin, Non steroidal anti-inflammatory drugs, Oxcarbazepine, Para-amino salicylic acid, Pergolide, Phenylbutazone, Pramipexole, Piroxicam, Pramipexole, Prednisolone, Prednisone, Rofecoxib, Sertraline, Sulindac, Tacrolimus, Tenoxicam, Tiaprofenic acid, Tocilizumab, Tolazoline, Tolmetin, Trimetrexate
Ear Nose Throat No underlying causes
Endocrine Cushing syndrome, Multiple endocrine neoplasia type 1, Zollinger-Ellison syndrome, primary hyperparathyroidism
Environmental No underlying causes
Gastroenterologic Crohn disease, Cushing ulcers, Dieulafoy's lesion, Duodenal ulcer, Eosinophilic gastroenteritis, Gastric ulcer, Oesophagitis, Zollinger-Ellison syndrome, Carcinoid tumours and carcinoid syndrome, Stomach cancer, Curling ulcers
Genetic No underlying causes
Hematologic Mastocytosis, Polycythaemia rubra vera, Primary thrombocythemia
Iatrogenic Mechanical ventilation
Infectious Disease Helicobacter pylori
Musculoskeletal / Ortho No underlying causes
Neurologic Cushing ulcers
Nutritional / Metabolic Hypercalcaemia
Obstetric/Gynecologic No underlying causes
Oncologic Carcinoid tumours and carcinoid syndrome, Stomach cancer, Zollinger-Ellison syndrome
Opthalmologic No underlying causes
Overdose / Toxicity Aceclofenac, Acemetacin, Alendronate, Aspirin, Azapropazone, Benoxaprofen, Bisphosphonates, Celecoxib, Clopidogrel, Diclofenac, Diflunisal, Ethanol, Etodolac, Etoricoxib, Fenbufen, Fenoprofen, Flurbiprofen, Glucocorticoids, Ibuprofen, Indomethacin, Ketoprofen, Laxative abuse, Mefenamic acid, Meloxicam, Nabumetone, Naproxen, Non steroidal anti-inflammatory drugs, Para-amino salicylic acid, Phenylbutazone, Piroxicam, Prednisolone, Rofecoxib, Sulindac, Tacrolimus, Tenoxicam, Tiaprofenic acid, Tolazoline, Trimetrexate
Psychiatric Curling ulcers
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma Burns
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Alcohol, Caffeine, Smoking

Causes in Alphabetical Order

Common causes [1]

Less common causes of peptic ulcer disease

Rare causes of peptic ulcer disease [1]


Genetic causes -[3]

  • Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.

Causes by organ sys

  • For an example of the causes by organ system table in a causes microchapter, click here.
Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Rosacea,Chronic idiopathic urticaria ,Psoriasis vulgaris ,Behcet's disease ,Alopecia areata,Sweet's syndrome [4]
Drug Side Effect serotonin reuptake -NSAIDs,Clopidogrel,spironolactone,sirolimus,bisphosphonates (when combined with NSAIDs),mycophenolate mofetil,spironolactone ,chemotherapy (hepatic infusion of 5 - fluorouracil ,selective serotonin reuptake inhibitor
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus
Environmental smoking, excess alcohol consumption, caffeine ,more common in patients with Diabetes Mellitus ,hypertension ,metabolic syndrome[5]
Gastroenterologic Crohn’s disease of the stomach or duodenum, Eosinophilic gastroduodenitis
Genetic Zollinger -Ellison syndrome associated with MEN TYPE 1 syndrome caused by mutation in MEN gene present on chromosome 11q 13
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Helicobacter pylori (60% gastric and 50-75% duodenal ulcers ), Herpes simplex virus type 1, Cytomegalovirus, Helicobacter heilmannii, Tuberculosis, syphilis, and mucormycosis
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Non-beta cell tumor ,carcinoid syndrome , gastrinomas
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric severe stress, depressed mood, suicidal ideation and psychological counseling [5]
Pulmonary COPD,Sarcoidosis
Renal/Electrolyte Hypercalcemia
Rheumatology/Immunology/Allergy Fibromyalgia[6]
Sexual No underlying causes
Trauma Cushing ulcers
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in alphabetical order[edit | edit source] List the causes of the disease in alphabetical order.

Cause 1 Alopecia areata Cause 2 Behcet's disease Cause 3 caffeine Cause 4 Cause 5 Cause 6 Cause 7 Cause 8 Cause 9 Cause 10

References

  1. ↑ 1.0 1.1 Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
  2. ↑ Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
  3. ↑ Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
  4. ↑ Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E; et al. (2014). "Helicobacter pylori infection and skin disorders". Hong Kong Med J. 20 (4): 317–24. doi:10.12809/hkmj134174. PMID 25045884.
  5. ↑ 5.0 5.1 Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW; et al. (2017). "The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article". Medicine (Baltimore). 96 (34): e7828. doi:10.1097/MD.0000000000007828. PMC 5572011. PMID 28834889.
  6. ↑ Wang KA, Wang JC, Lin CL, Tseng CH (2017) Association between fibromyalgia syndrome and peptic ulcer disease development. PLoS One 12 (4):e0175370. DOI:10.1371/journal.pone.0175370 PMID: 28384332


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