Autoimmune polyendocrine syndrome classification: Difference between revisions
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{{familytree | | C01 | | | | | C02 | | | | | C03 |C01=Autoimmune polyendocrine syndrome type 1|C02=Autoimmune polyendocrine syndrome type 2|C03=Autoimmune polyendocrine syndrome type 3}} | {{familytree | | C01 | | | | | C02 | | | | | C03 |C01=Autoimmune polyendocrine syndrome type 1|C02=Autoimmune polyendocrine syndrome type 2|C03=Autoimmune polyendocrine syndrome type 3}} | ||
{{familytree | | |!| | | | | | |!| | | | | | |!| }} | {{familytree | | |!| | | | | | |!| | | | | | |!| }} | ||
{{familytree | | D01 | | | | | D02 | | | | | D03 |D01=•Mucocutaneous candidiasis<br> | {{familytree | | D01 | | | | | D02 | | | | | D03 |D01=•Mucocutaneous [[candidiasis]]<br> •[[Hypoparathyroidism]]<br> •[[Addison's disease]]<br>|D02=•[[Addison's disease]]<br>•[[Autoimmune thyroiditis]]<br> •[[Diabetes mellitus type 1]]|D03=•[[Autoimmune thyroiditis]]<br> •[[Diabetes mellitus type 1]]<br> •[[Pernicious anemia]]<br>}} | ||
{{familytree/end}} | {{familytree/end}} | ||
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{{familytree | | C01 | | | | | C02 | | | | | C03 |C01=Autoimmune polyendocrine syndrome type 3A|C02=Autoimmune polyendocrine syndrome type 3B|C03=Autoimmune polyendocrine syndrome type 3C}} | {{familytree | | C01 | | | | | C02 | | | | | C03 |C01=Autoimmune polyendocrine syndrome type 3A|C02=Autoimmune polyendocrine syndrome type 3B|C03=Autoimmune polyendocrine syndrome type 3C}} | ||
{{familytree | | |!| | | | | | |!| | | | | | |!| }} | {{familytree | | |!| | | | | | |!| | | | | | |!| }} | ||
{{familytree | | D01 | | | | | D02 | | | | | D03 |D01= | {{familytree | | D01 | | | | | D02 | | | | | D03 |D01=•[[Autoimmune thyroiditis]]<br> •Immune mediated [[diabetes mellitus]]<br>|D02=•[[Autoimmune thyroiditis]]<br>•[[Pernicious anemia]]<br>|D03=•[[Autoimmune thyroiditis]]<br>•[[Vitiligo]]/[[Alopecia]]<br>}} | ||
{{familytree/end}} | {{familytree/end}} | ||
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Other diseases featuring polyendocrine autoimmunity: | Other diseases featuring polyendocrine autoimmunity: | ||
* Chromosomal abnormalities ([[Down's syndrome]]) increase the risk of endocrine autoimmunity. | * Chromosomal abnormalities ([[Down's syndrome]]) increase the risk of endocrine autoimmunity. | ||
* POEMS syndrome -(Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes). The cause is a [[paraprotein]] excreted by a plasmacytoma or [[multiple myeloma]]; other features are [[polyneuropathy]], organomegaly ([[hepatomegaly]] and [[splenomegaly]]), M-protein (paraprotein) and skin changes. | * POEMS syndrome -([[Polyneuropathy]], [[Organomegaly]], [[Endocrinopathy]], [[M-protein]], [[Skin]] changes). The cause is a [[paraprotein]] excreted by a plasmacytoma or [[multiple myeloma]]; other features are [[polyneuropathy]], organomegaly ([[hepatomegaly]] and [[splenomegaly]]), M-protein (paraprotein) and skin changes. | ||
==References== | ==References== | ||
Revision as of 18:33, 19 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]
Overview
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3. APS type 1 commonly presents with mucocutaneous candidiasis, hypoparathyroidism and Addison's disease. APS type 2 commonly presents with Addison's disease, autoimmune thyroiditis and diabetes mellitus type 1. APS type 3 commonly presents with autoimmune thyroiditis, diabetes mellitus type 1 and pernicious anemia.
Classification
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3.[1][2][3]
| Autoimmune polyendocrine syndrome (APS) | |||||||||||||||||||||||||||||||||||
| Autoimmune polyendocrine syndrome type 1 | Autoimmune polyendocrine syndrome type 2 | Autoimmune polyendocrine syndrome type 3 | |||||||||||||||||||||||||||||||||
| •Mucocutaneous candidiasis •Hypoparathyroidism •Addison's disease | •Addison's disease •Autoimmune thyroiditis •Diabetes mellitus type 1 | •Autoimmune thyroiditis •Diabetes mellitus type 1 •Pernicious anemia | |||||||||||||||||||||||||||||||||
Autoimmune polyendocrine syndrome (APS) type 3 can be further classified into APS type 3A, APS type 3B and APS type 3C.
| Autoimmune polyendocrine syndrome type 3 | |||||||||||||||||||||||||||||||||||
| Autoimmune polyendocrine syndrome type 3A | Autoimmune polyendocrine syndrome type 3B | Autoimmune polyendocrine syndrome type 3C | |||||||||||||||||||||||||||||||||
| •Autoimmune thyroiditis •Immune mediated diabetes mellitus | •Autoimmune thyroiditis •Pernicious anemia | •Autoimmune thyroiditis •Vitiligo/Alopecia | |||||||||||||||||||||||||||||||||
Other diseases
Other diseases featuring polyendocrine autoimmunity:
- Chromosomal abnormalities (Down's syndrome) increase the risk of endocrine autoimmunity.
- POEMS syndrome -(Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes). The cause is a paraprotein excreted by a plasmacytoma or multiple myeloma; other features are polyneuropathy, organomegaly (hepatomegaly and splenomegaly), M-protein (paraprotein) and skin changes.
References
- ↑ Betterle C, Zanchetta R (2003). "Update on autoimmune polyendocrine syndromes (APS)". Acta Biomed. 74 (1): 9–33. PMID 12817789.
- ↑ Forcier RJ, McIntyre OR, Frey WG, Andrada JA, Streiff RR (1972). "Autoimmunity and multiple endocrine abnormalities". Arch. Intern. Med. 129 (4): 638–41. PMID 5067225.
- ↑ Eisenbarth GS, Gottlieb PA (2004). "Autoimmune polyendocrine syndromes". N. Engl. J. Med. 350 (20): 2068–79. doi:10.1056/NEJMra030158. PMID 15141045.