Thyroid nodule causes: Difference between revisions
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{{CMG}} ; {{AE}} {{MIR}} | {{CMG}} ; {{AE}} {{MIR}} | ||
==Overview== | ==Overview== | ||
The most important causes of thyroid nodule development include: [[Goiter|Multinodular (sporadic) goiter]], [[Hashimoto's thyroiditis]], [[cysts]], macrofollicular/microfollicular adenomas, childhood [[radioiodine]] exposure, familial history, and [[ | The most important causes of thyroid nodule development include: [[Goiter|Multinodular (sporadic) goiter]], [[Hashimoto's thyroiditis]], [[cysts]], macrofollicular/microfollicular adenomas, childhood [[radioiodine]] exposure, familial history, and gene [[mutations]] include N&H ras, RET, Gsp, C-MET (α and β subunit), TRK, EGF / EGF-R, and P53 mutation. | ||
== Causes == | == Causes == | ||
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** [[Goiter|Multinodular (sporadic) goiter ("colloid adenoma")]] | ** [[Goiter|Multinodular (sporadic) goiter ("colloid adenoma")]] | ||
** [[Hashimoto thyroiditis| Hashimoto's (chronic lymphocytic) thyroiditis]] | ** [[Hashimoto thyroiditis| Hashimoto's (chronic lymphocytic) thyroiditis]] | ||
** [[Cysts]] (colloid, simple, or hemorrhagic) | ** [[Cysts]] (colloid, simple, or [[hemorrhagic]]) | ||
** Follicular adenomas | ** Follicular [[adenomas]] | ||
** Macrofollicular adenomas | ** Macrofollicular [[adenomas]] | ||
** Microfollicular or cellular adenomas | ** Microfollicular or cellular [[adenomas]] | ||
** Hürthle cell (oxyphil cell) adenomas | ** Hürthle cell (oxyphil cell) [[adenomas]] | ||
** Macro- or microfollicular patterns | ** Macro- or microfollicular patterns | ||
* Causes of malignant nodule mutations: | * Causes of [[malignant]] nodule [[mutations]]: | ||
** Childhood [[radioiodine]] exposure | ** Childhood [[radioiodine]] exposure | ||
** Familial history | ** Familial history | ||
The most important genes which their mutation can lead to thyroid cancer include: | The most important [[genes]] which their [[Mutations|mutation]] can lead to [[thyroid cancer]] include: | ||
** N&H ras | ** N&H ras | ||
** RET | ** [[RET gene|RET]] | ||
** Gsp | ** Gsp | ||
** C-MET (α and β subunit) | ** [[C-MET]] (α and β subunit) | ||
** TRK | ** [[TRK]] | ||
** EGF / EGF-R | ** EGF / EGF-R | ||
** P53 | ** [[P53]] | ||
PMC2879398 | PMC2879398 | ||
Revision as of 13:15, 20 October 2017
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Thyroid nodule Microchapters |
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Thyroid nodule causes On the Web |
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American Roentgen Ray Society Images of Thyroid nodule causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Overview
The most important causes of thyroid nodule development include: Multinodular (sporadic) goiter, Hashimoto's thyroiditis, cysts, macrofollicular/microfollicular adenomas, childhood radioiodine exposure, familial history, and gene mutations include N&H ras, RET, Gsp, C-MET (α and β subunit), TRK, EGF / EGF-R, and P53 mutation.
Causes
The most important causes of thyroid nodule development include:
- Causes of benign thyroid nodule:
- Multinodular (sporadic) goiter ("colloid adenoma")
- Hashimoto's (chronic lymphocytic) thyroiditis
- Cysts (colloid, simple, or hemorrhagic)
- Follicular adenomas
- Macrofollicular adenomas
- Microfollicular or cellular adenomas
- Hürthle cell (oxyphil cell) adenomas
- Macro- or microfollicular patterns
- Causes of malignant nodule mutations:
- Childhood radioiodine exposure
- Familial history
The most important genes which their mutation can lead to thyroid cancer include:
PMC2879398
PMC4481656
20693948
PMC4481656