Marburg hemorrhagic fever physical examination: Difference between revisions

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{{CMG}}{{AE}}
{{CMG}}{{AE}}
==Overview==
==Overview==
Ebola hemorrhagic fever is commonly associated with fever on physical examination at admission. At advanced stages of the disease, physical examination findings are more pertinent and often include unstable vital signs, such as tachycardia or relative bradycardia, orthostatic hypotension, and tachypnea. Physical examination may also be remarkable for abdominal tenderness and distension, evidence of mucosal or visceral bleeding, and neurological impairment.<ref name="FeldmannGeisbert2011">{{cite journal|last1=Feldmann|first1=Heinz|last2=Geisbert|first2=Thomas W|title=Ebola haemorrhagic fever|journal=The Lancet|volume=377|issue=9768|year=2011|pages=849–862|issn=01406736|doi=10.1016/S0140-6736(10)60667-8}}</ref><ref name="FormentyHatz1999">{{cite journal|last1=Formenty|first1=Pierre|last2=Hatz|first2=Christophe|last3=Le Guenno|first3=Bernard|last4=Stoll|first4=Agnés|last5=Rogenmoser|first5=Philipp|last6=Widmer|first6=Andreas|title=Human Infection Due to Ebola Virus, Subtype Côte d'Ivoire: Clinical and Biologic Presentation|journal=The Journal of Infectious Diseases|volume=179|issue=s1|year=1999|pages=S48–S53|issn=0022-1899|doi=10.1086/514285}}</ref><ref name="pmid10667555">{{cite journal| author=Gradon J| title=An outbreak of Ebola virus: lessons for everyday activities in the intensive care unit. | journal=Crit Care Med | year= 2000 | volume= 28 | issue= 1 | pages= 284-5 | pmid=10667555 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10667555  }} </ref>
Marburg hemorrhagic fever is commonly associated with [[fever]] on physical examination at admission. At advanced stages of the disease, physical examination findings are more pertinent and often include unstable vital signs, such as tachycardia or relative bradycardia, orthostatic [[hypotension]], and [[tachypnea]]. Physical examination may also be remarkable for [[abdominal tenderness]] and [[Abdominal distension|distension]], evidence of [[mucosal]] or [[visceral]] [[bleeding]], and neurological impairment.


==Physical Examination==
==Physical Examination==
===Appearance of the Patient===
===Appearance of the Patient===
The general appearance of the patient depends on the stage of the disease. Typically, patients demonstrate [[prostration]], may be [[nauseated]] and [[vomiting]], and less commonly present with signs of hemorrhage, such as epistaxis or gingival bleeding. In later stages of the disease, patients are often brought with convulsions or are in a state of shock, stupor, or coma.<ref name="BorchertMutyaba2011">{{cite journal|last1=Borchert|first1=Matthias|last2=Mutyaba|first2=Imaam|last3=Van Kerkhove|first3=Maria D|last4=Lutwama|first4=Julius|last5=Luwaga|first5=Henry|last6=Bisoborwa|first6=Geoffrey|last7=Turyagaruka|first7=John|last8=Pirard|first8=Patricia|last9=Ndayimirije|first9=Nestor|last10=Roddy|first10=Paul|last11=Van der Stuyft|first11=Patrick|title=Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned|journal=BMC Infectious Diseases|volume=11|issue=1|year=2011|pages=357|issn=1471-2334|doi=10.1186/1471-2334-11-357}}</ref>
The general appearance of the patient depends on the stage of the disease. Typically, patients demonstrate [[prostration]], may be [[nauseated]] and [[vomiting]], and less commonly present with signs of [[hemorrhage]], such as [[epistaxis]] or [[gingival bleeding]]. In later stages of the disease, patients are often brought with [[convulsions]] or are in a state of [[shock]], [[stupor]], or [[coma]].


===Vitals===
===Vitals===
====Temperature====
* High-grade [[fever]] (most common presenting sign)
* High-grade [[fever]] is often present in more than 80% of patients. Fever is the most common presenting sign of Ebola virus infection.


====Pulse====
*[[Tachycardia]]
*[[Tachycardia]]
* Relative [[bradycardia]]
* Relative [[bradycardia]]


====Blood Pressure====
* [[Hypotension]] (SBP<90 mmHg and/or DBP<60 mmHg)
* [[Hypotension]] (SBP<90 mmHg and/or DBP<60 mmHg)
* [[Postural hypotension]] is common in dehydrated patients with inadequate volume repletion
* [[Postural hypotension]] (common in dehydrated patients with inadequate volume repletion)
 
====Respiratory Rate====
*[[Signs]] of [[shortness of breath|respiratory difficulty]] may be present, such as:
:* [[Intercostal]] retractions
:* Paradoxical [[breathing]]
:* [[Nasal]] flare
*[[Tachypnea]] often precedes death during final hours of infection.


===Skin===
===Skin===
[[Bleeding|Hemorrhagic]] manifestations tend to occur during the more severe stages of the disease and may include:<ref name="FeldmannGeisbert2011">{{cite journal|last1=Feldmann|first1=Heinz|last2=Geisbert|first2=Thomas W|title=Ebola haemorrhagic fever|journal=The Lancet|volume=377|issue=9768|year=2011|pages=849–862|issn=01406736|doi=10.1016/S0140-6736(10)60667-8}}</ref>
[[Bleeding|Hemorrhagic]] manifestations tend to occur during the more severe stages of the disease and may include:
:* [[Maculopapular rash]] on the [[trunk]], usually between the 5th and 7th day of the condition, associated with different stages of [[erythema]] and [[desquamation]], which is a valuable finding in differentiating Ebola from other diseases.
:* [[Maculopapular rash]] on the [[trunk]]
:* [[Petechiae]] is a common finding
:* [[Petechiae]]
:* [[Ecchymoses]] is a common finding
:* [[Ecchymoses]]
:* [[Mucosal]] [[hemorrhages]] is a common finding
:* [[Mucosal]] [[hemorrhages]]
:* Uncontrolled [[bleeding]] from [[venipuncture]] locals is a common finding
:* Uncontrolled [[bleeding]] from [[venipuncture]] sites


===Eyes===
===HEENT===
* [[Conjunctival hemorrhage]] is a the most common sign of abnormal clotting
* [[Conjunctival hemorrhage]] (most common sign of abnormal clotting)
* [[Conjunctivitis]]
* [[Conjunctivitis]]


===Nose===
* [[Epistaxis]]
* [[Epistaxis]] may be present.
* [[Nasal discharge]]
* [[Nasal discharge]] may be present.<ref name="FeldmannGeisbert2011">{{cite journal|last1=Feldmann|first1=Heinz|last2=Geisbert|first2=Thomas W|title=Ebola haemorrhagic fever|journal=The Lancet|volume=377|issue=9768|year=2011|pages=849–862|issn=01406736|doi=10.1016/S0140-6736(10)60667-8}}</ref>


===Throat===
* [[Mucosal]] [[hyperemia]] of the [[oral cavity]]
* [[Mucosal]] [[hyperemia]] of the [[oral cavity]] is a common finding.
* [[Bleeding gums]]
* [[Bleeding gums]] is a common finding.
 
===Lungs===
*[[Signs]] of [[shortness of breath|respiratory difficulty]] may be present, such as:
:* [[Intercostal]] retractions
:* Paradoxical [[breathing]]
:* [[Nasal]] flare
*[[Tachypnea]] (often precedes death during final hours of infection)


===Abdomen===
===Abdomen===
* [[Abdominal tenderness]] may suggest [[pancreatitis]], [[intestinal swelling]], or [[mesenteric lymphadenopathy]]
* [[Abdominal tenderness]] (may suggest [[pancreatitis]], [[Intestine|intestinal]] [[swelling]], or [[Mesentery|mesenteric]] [[lymphadenopathy]])
* [[Abdominal distention]] may suggest [[paralytic ileus]]
* [[Abdominal distention]] (may suggest [[paralytic ileus]])
*Tender hepatomegaly
*[[Tenderness (medicine)|Tender]] [[hepatomegaly]]
*Splenomegaly
*[[Splenomegaly]]


===Extremities===
===Extremities===
* [[Edema]] may be present.
* [[Edema]] may be present


===Neurologic===
===Neurologic===
* [[Obtundation]] may be present.<ref name="pmid9988156">{{cite journal| author=Ndambi R, Akamituna P, Bonnet MJ, Tukadila AM, Muyembe-Tamfum JJ, Colebunders R| title=Epidemiologic and clinical aspects of the Ebola virus epidemic in Mosango, Democratic Republic of the Congo, 1995. | journal=J Infect Dis | year= 1999 | volume= 179 Suppl 1 | issue=  | pages= S8-10 | pmid=9988156 | doi=10.1086/514297 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9988156  }} </ref><ref name="pmid9988155">{{cite journal| author=Bwaka MA, Bonnet MJ, Calain P, Colebunders R, De Roo A, Guimard Y et al.| title=Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. | journal=J Infect Dis | year= 1999 | volume= 179 Suppl 1 | issue=  | pages= S1-7 | pmid=9988155 | doi=10.1086/514308 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9988155  }} </ref><ref name="pmid21084112">{{cite journal| author=Feldmann H, Geisbert TW| title=Ebola haemorrhagic fever. | journal=Lancet | year= 2011 | volume= 377 | issue= 9768 | pages= 849-62 | pmid=21084112 | doi=10.1016/S0140-6736(10)60667-8 | pmc=PMC3406178 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21084112  }} </ref>
* [[Obtundation]] may be present
*[[Stupor]]
*[[Stupor]]
*[[Coma]]
*[[Coma]]
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==References==
==References==
{{reflist|2}}
{{reflist|2}}


[[Category:Disease]]
[[Category:Disease]]

Revision as of 20:05, 20 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief:

Overview

Marburg hemorrhagic fever is commonly associated with fever on physical examination at admission. At advanced stages of the disease, physical examination findings are more pertinent and often include unstable vital signs, such as tachycardia or relative bradycardia, orthostatic hypotension, and tachypnea. Physical examination may also be remarkable for abdominal tenderness and distension, evidence of mucosal or visceral bleeding, and neurological impairment.

Physical Examination

Appearance of the Patient

The general appearance of the patient depends on the stage of the disease. Typically, patients demonstrate prostration, may be nauseated and vomiting, and less commonly present with signs of hemorrhage, such as epistaxis or gingival bleeding. In later stages of the disease, patients are often brought with convulsions or are in a state of shock, stupor, or coma.

Vitals

  • High-grade fever (most common presenting sign)

Skin

Hemorrhagic manifestations tend to occur during the more severe stages of the disease and may include:

HEENT

Lungs

  • Tachypnea (often precedes death during final hours of infection)

Abdomen

Extremities

Neurologic

References