Plummer-Vinson syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Laboratory Findings

Blood tests show a hypochromic microcytic anemia that is consistent with an iron-deficiency anemia. Biopsy of involved mucosa typically reveals epithelial atrophy (shrinking) and varying amounts of submucosal chronic inflammation. Epithelial atypia or dysplasia may be present.

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

Laboratory findings consistent with the diagnosis of Plummer-Vinson syndrome include presence of iron deficiency anemia:

• Iron studies should be done in patients with microcytic anemia to confirm the diagnosis of iron deficiency anemia. The tests usually done for iron deficiency anemia are:
  • Serum iron- Decreased in iron deficiency
  • Transferrin- Elevated in iron deficiency
  • Total iron binding capacity (TIBC)- Elevated in iron deficiency.
  • Transferrin saturation- derived by dividing the serum iron by the TIBC. Decreased in iron deficiency.
  • Ferritin- Indicator of body iron stores and is low in iron deficiency. However, ferritin also acts as an acute phase reactant and can be unreliable in inflammatory illness.

Change in lab values in iron deficiency anemia

Change	Parameter
Decrease	ferritin, hemoglobin, MCV
Increase	TIBC, transferrin, RDW