Sandbox cerebral palsy: Difference between revisions
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**Layer of mucus, secreted by surface epithelial cells and Foveolar cells. | **Layer of mucus, secreted by surface epithelial cells and Foveolar cells. | ||
**Bicarbonate ions, secreted by the surface epithelial cells. | **Bicarbonate ions, secreted by the surface epithelial cells. | ||
[[Image: Stomach mucosal layer labeled.svg.png|center|]] | |||
===Mechanism of Action=== | ===Mechanism of Action=== | ||
*The insoluble mucus forms a protective gel-like coating over the entire surface of the gastric mucosa. | *The insoluble mucus forms a protective gel-like coating over the entire surface of the gastric mucosa. | ||
Revision as of 15:15, 26 October 2017
Pathophysiology
Mucosal barrier
- The gastric mucosa is protected from the acidic environment by mucus, bicarbonate, prostaglandins, and blood flow.
- This mucosal barrier consists of three protective components which include:
- Layer of epithelial cells lining.
- Layer of mucus, secreted by surface epithelial cells and Foveolar cells.
- Bicarbonate ions, secreted by the surface epithelial cells.
Mechanism of Action
- The insoluble mucus forms a protective gel-like coating over the entire surface of the gastric mucosa.
- The mucus protects the gastric mucosa from autodigestion by e.g. pepsin and from erosion by acids and other caustic materials that are ingested.
- The bicarbonate ions act to neutralize harsh acids.
- If the balance of gastric acid secretion and mucosal defenses is disrupted, acid interacts with the epithelium to cause damage