Sandbox cerebral palsy: Difference between revisions

Revision as of 15:20, 26 October 2017

The gastric mucosa is protected from the acidic environment by mucus, bicarbonate, prostaglandins, and blood flow.
This mucosal barrier consists of three protective components which include:
- Layer of epithelial cells lining.
- Layer of mucus, secreted by surface epithelial cells and Foveolar cells.
- Bicarbonate ions, secreted by the surface epithelial cells.

The insoluble mucus forms a protective gel-like coating over the entire surface of the gastric mucosa.
The mucus protects the gastric mucosa from autodigestion by e.g. pepsin and from erosion by acids and other caustic materials that are ingested.
The bicarbonate ions act to neutralize harsh acids.
If the balance of gastric acid secretion and mucosal defenses is disrupted, acid interacts with the epithelium to cause damage

Defense mechanisms of Gastric mucosal barrier
Mucus layer	Forms a protective gel-like coating over the entire gastric mucosal surface
Epithelial layer	Epithelial cell layer are bound by tight junctions that repel fluids
Bicarbonate ions	Neutralize acids

@@ Line 13: / Line 13: @@
 *The bicarbonate ions act to neutralize harsh acids.
 *If the balance of gastric acid secretion and mucosal defenses is disrupted, acid interacts with the epithelium to cause damage
+{| class="wikitable"
+! colspan="2" |Defense mechanisms of
+Gastric mucosal barrier
+|-
+|Mucus layer
+|Forms a protective gel-like coating over the entire gastric mucosal surface
+|-
+|Epithelial layer
+|Epithelial cell layer are bound by tight junctions that repel fluids
+|-
+|Bicarbonate ions
+|Neutralize acids
+|}