Hypoparathyroidism diagnostic criteria: Difference between revisions
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==Overview== | ==Overview== | ||
The diagnosis of hypoparathyroidism is made when the following diagnostic criteria are met | The diagnosis of hypoparathyroidism is made when the following diagnostic criteria are met, [[hypocalcemia]] ([[Hypoparathyroidism laboratory findings|albumin-adjusted]]) confirmed on at least two occasions separated by at least 2 weeks, [[parathyroid hormone]] ([[PTH]]) concentration, by second- or third-generation [[immunoassay]], that is undetectable or inappropriately low (ie, <20 pg/mL) in the presence of [[hypocalcemia]] on at least two occasions, [[phosphate]] levels in the upper normal or frankly elevated range (helpful but not mandatory), and chronic hypoparathyroidism is established only after 6 months after [[neck surgery]]. | ||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
*The diagnosis of hypoparathyroidism is made when | *The diagnosis of hypoparathyroidism is made when the following diagnostic criteria are met:<ref name="pmid26943719">{{cite journal |vauthors=Brandi ML, Bilezikian JP, Shoback D, Bouillon R, Clarke BL, Thakker RV, Khan AA, Potts JT |title=Management of Hypoparathyroidism: Summary Statement and Guidelines |journal=J. Clin. Endocrinol. Metab. |volume=101 |issue=6 |pages=2273–83 |year=2016 |pmid=26943719 |doi=10.1210/jc.2015-3907 |url=}}</ref><ref name="pmid21812031">{{cite journal |vauthors=Bilezikian JP, Khan A, Potts JT, Brandi ML, Clarke BL, Shoback D, Jüppner H, D'Amour P, Fox J, Rejnmark L, Mosekilde L, Rubin MR, Dempster D, Gafni R, Collins MT, Sliney J, Sanders J |title=Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research |journal=J. Bone Miner. Res. |volume=26 |issue=10 |pages=2317–37 |year=2011 |pmid=21812031 |pmc=3405491 |doi=10.1002/jbmr.483 |url=}}</ref> | ||
**[[Hypocalcemia]] ([[Hypoparathyroidism laboratory findings|albumin-adjusted]]) confirmed on at least two occasions separated by at least 2 weeks. | **[[Hypocalcemia]] ([[Hypoparathyroidism laboratory findings|albumin-adjusted]]) confirmed on at least two occasions separated by at least 2 weeks. | ||
**[[Parathyroid hormone]] ([[PTH]]) concentration, by second- or third-generation [[immunoassay]], that is undetectable or inappropriately low (ie, <20 pg/mL) in the presence of [[hypocalcemia]] on at least two occasions. | **[[Parathyroid hormone]] ([[PTH]]) concentration, by second- or third-generation [[immunoassay]], that is undetectable or inappropriately low (ie, <20 pg/mL) in the presence of [[hypocalcemia]] on at least two occasions. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
The diagnosis of hypoparathyroidism is made when the following diagnostic criteria are met, hypocalcemia (albumin-adjusted) confirmed on at least two occasions separated by at least 2 weeks, parathyroid hormone (PTH) concentration, by second- or third-generation immunoassay, that is undetectable or inappropriately low (ie, <20 pg/mL) in the presence of hypocalcemia on at least two occasions, phosphate levels in the upper normal or frankly elevated range (helpful but not mandatory), and chronic hypoparathyroidism is established only after 6 months after neck surgery.
Diagnostic Criteria
- The diagnosis of hypoparathyroidism is made when the following diagnostic criteria are met:[1][2]
- Hypocalcemia (albumin-adjusted) confirmed on at least two occasions separated by at least 2 weeks.
- Parathyroid hormone (PTH) concentration, by second- or third-generation immunoassay, that is undetectable or inappropriately low (ie, <20 pg/mL) in the presence of hypocalcemia on at least two occasions.
- Phosphate levels in the upper normal or frankly elevated range (helpful but not mandatory).
- After neck surgery, chronic hypoparathyroidism is established only after 6 months.
References
- ↑ Brandi ML, Bilezikian JP, Shoback D, Bouillon R, Clarke BL, Thakker RV, Khan AA, Potts JT (2016). "Management of Hypoparathyroidism: Summary Statement and Guidelines". J. Clin. Endocrinol. Metab. 101 (6): 2273–83. doi:10.1210/jc.2015-3907. PMID 26943719.
- ↑ Bilezikian JP, Khan A, Potts JT, Brandi ML, Clarke BL, Shoback D, Jüppner H, D'Amour P, Fox J, Rejnmark L, Mosekilde L, Rubin MR, Dempster D, Gafni R, Collins MT, Sliney J, Sanders J (2011). "Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research". J. Bone Miner. Res. 26 (10): 2317–37. doi:10.1002/jbmr.483. PMC 3405491. PMID 21812031.