Whipple's disease classification: Difference between revisions
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'''Whipple's disease classification based on organ involvement''' | '''Whipple's disease classification based on organ involvement''' | ||
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{{familytree | | | | | | | | | | | | | | | | | | {{familytree | B01 | | | | | | | | | | | | | | B02 |B01=Systemic involvement|B02=Localized involvement}} | ||
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{{familytree | {{familytree | | | | | E01 | | E02 | | E03 | | E04 | | E05 | | E06 | | E07 | | | | |E01=[[Heart]]|E02=[[CNS]]|E03=[[Eye]]|E04=[[Lung]]|E05=[[Bone]]|E06=[[Serosa]]|E07=[[Skin]]}} | ||
{{familytree | {{familytree | | | | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | | | |}} | ||
{{familytree | {{familytree | | | | | E01 | | E02 | | E03 | | E04 | | E05 | | E06 | | E07 | | | | | ||
{{familytree | |E01=<div style="float: left; text-align: left> | ||
*Blood-culture negative endocarditis | *Blood-culture negative [[endocarditis]] | ||
|E02= | *Adhesive [[pericarditis]] | ||
*Encephalitis | *[[Myocardial fibrosis]]</div> | ||
*Progressive dementia | |E02=<div style="float: left; text-align: left> | ||
*Cerebellar ataxia | *[[Encephalitis]] | ||
*Supranuclear ophthalmoplegia|E03= | *Progressive [[dementia]] | ||
*Uveitis | *[[Cerebellar ataxia]] | ||
|E04=|E05=*Arthritis | *Personality changes | ||
*Spondylodiscitis|E06=|E07=}} | *[[Hemiparesis]] | ||
*[[Seizure]] | |||
*[[Wernicke’s encephalopathy] | |||
*[[Hypothalamic]] involvement | |||
*[[Supranuclear ophthalmoplegia]] | |||
</div> | |||
|E03=<div style="float: left; text-align: left> | |||
*[[Uveitis]] | |||
*[[Vitritis]] | |||
*[[Retinitis]] | |||
*[[Retrobulbar neuritis]] | |||
*[[Papilledema]] | |||
</div> | |||
|E04= <div style="float: left; text-align: left> | |||
|E05=<div style="float: left; text-align: left> | |||
*Arthritis | |||
*Spondylodiscitis</div> | |||
|E06=<div style="float: left; text-align: left> | |||
</div> | |||
|E07=<div style="float: left; text-align: left> | |||
</div>}} | |||
{{familytree/end}} | {{familytree/end}} | ||
Revision as of 19:23, 31 October 2017
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Whipple's disease Microchapters |
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Whipple's disease classification On the Web |
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Risk calculators and risk factors for Whipple's disease classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Whipple’s disease may be classified into 4 groups based on clinical manifestation: Acute infection, asymptomatic carrier state, the classic Whipple’s disease, and localized chronic infection.
Classification
- Whipple's disease may be classified to 2 groups of acute and chronic based on the duration.
- Whipple's disease may be classified to 2 groups of systemic and localized infection based on organ involvement.
- Tropheryma whipplei infection may be classified to 4 groups based on the clinical manifestation:[1][2]
- Acute infections such as:
- Asymptomatic carrier state
- The classic Whipple’s disease
- Localized involvement of different organs including:
Whipple's disease classification based on the duration
| Whipple's disease classification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Acute | Chronic | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gastroenteritis | Pneumonia | Bacteremia | Asymptomatic carrier state | Classic Whipple's disease | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Chronic localized infection | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Whipple's disease classification based on organ involvement
{{familytree | | | | | E01 | | E02 | | E03 | | E04 | | E05 | | E06 | | E07 | | | |
|E01=- Blood-culture negative endocarditis
- Adhesive pericarditis
- Myocardial fibrosis
- Encephalitis
- Progressive dementia
- Cerebellar ataxia
- Personality changes
- Hemiparesis
- Seizure
- [[Wernicke’s encephalopathy]
- Hypothalamic involvement
- Supranuclear ophthalmoplegia
|E05=
|E06=
|E07=
}}
- Arthritis
- Spondylodiscitis
| Whipple's disease classification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Systemic involvement | Localized involvement | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Heart | CNS | Eye | Lung | Bone | Serosa | Skin | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References
- ↑ Marth, Thomas (2009). "New Insights into Whipple's Disease – A Rare Intestinal Inflammatory Disorder". Digestive Diseases. 27 (4): 494–501. doi:10.1159/000233288. ISSN 1421-9875.
- ↑ Street, Sara; Donoghue, Helen D; Neild, GH (1999). "Tropheryma whippelii DNA in saliva of healthy people". The Lancet. 354 (9185): 1178–1179. doi:10.1016/S0140-6736(99)03065-2. ISSN 0140-6736.