Whipple's disease classification: Difference between revisions

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Revision as of 19:40, 31 October 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Whipple’s disease may be classified into 4 groups based on clinical manifestation: Acute infection, asymptomatic carrier state, the classic Whipple’s disease, and localized chronic infection.

Classification

Whipple's disease may be classified to 2 groups of acute and chronic based on the duration.
Whipple's disease may be classified to 2 groups of systemic and localized infection based on organ involvement.
Tropheryma whipplei infection may be classified to 4 groups based on the clinical manifestation:^[1]^[2]
- Acute infections such as:
- Asymptomatic carrier state
- The classic Whipple’s disease
- Localized involvement of different organs including:
  - Heart:
  - CNS:
  - Eyes:
  - Lung:
  - Bone:
  - Serosa:
  - Skin:

Whipple's disease classification based on the duration

Whipple's disease classification

Acute

Chronic

Gastroenteritis

Pneumonia

Bacteremia

Asymptomatic carrier state

Classic Whipple's disease

Chronic localized infection

Whipple's disease classification based on organ involvement

{{familytree | | | | | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | D07 | | | | |D01=• Blood-culture negative endocarditis
• Adhesive pericarditis
• Myocardial fibrosis |D02=• Encephalitis
• Progressive dementia
• Cerebellar ataxia
• Personality changes
• Hemiparesis
• Seizure
• [[Wernicke’s encephalopathy]
• Hypothalamic involvement
• Supranuclear ophthalmoplegia|D03=• Uveitis
• Vitritis
• Retinitis
• Retrobulbar neuritis
• Papilledema|D04= |D05=• Arthritis
• Spondylodiscitis|D06=|D07=}}

Whipple's disease classification

Systemic involvement

Localized involvement

References

↑ Marth, Thomas (2009). "New Insights into Whipple's Disease – A Rare Intestinal Inflammatory Disorder". Digestive Diseases. 27 (4): 494–501. doi:10.1159/000233288. ISSN 1421-9875.
↑ Street, Sara; Donoghue, Helen D; Neild, GH (1999). "Tropheryma whippelii DNA in saliva of healthy people". The Lancet. 354 (9185): 1178–1179. doi:10.1016/S0140-6736(99)03065-2. ISSN 0140-6736.

Template:WH Template:WS

[Marth2009-1] Marth, Thomas (2009). "New Insights into Whipple's Disease – A Rare Intestinal Inflammatory Disorder". Digestive Diseases. 27 (4): 494–501. doi:10.1159/000233288. ISSN 1421-9875.

[StreetDonoghue1999-2] Street, Sara; Donoghue, Helen D; Neild, GH (1999). "Tropheryma whippelii DNA in saliva of healthy people". The Lancet. 354 (9185): 1178–1179. doi:10.1016/S0140-6736(99)03065-2. ISSN 0140-6736.

[1]

[2]

@@ Line 39: / Line 39: @@
 '''Whipple's disease classification based on organ involvement'''
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+{{familytree | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | | | | | | | |A01=Whipple's disease classification}}
-{{familytree | |,|-|-|-|-|-|-|-|^|-|-|-|-|-|-|-|.| |}}
+{{familytree | |,|-|-|-|-|-|-|-|^|-|-|-|-|-|-|-|.| | | | | | | | | | | | | | | | | |}}
-{{familytree | B01 | | | | | | | | | | | | | | B02 |B01=Systemic involvement|B02=Localized involvement}}
+{{familytree | B01 | | | | | | | | | | | | | | B02 | | | | | | | | | | | | | | | | |B01=Systemic involvement|B02=Localized involvement}}
 {{familytree | | | | | |,|-|-|-|v|-|-|-|v|-|-|-|+|-|-|-|v|-|-|-|v|-|-|-|.| | | | | |}}
-{{familytree | | | | | E01 | | E02 | | E03 | | E04 | | E05 | | E06 | | E07 | | | | |E01=[[Heart]]|E02=[[CNS]]|E03=[[Eye]]|E04=[[Lung]]|E05=[[Bone]]|E06=[[Serosa]]|E07=[[Skin]]}}
+{{familytree | | | | | C01 | | C02 | | C03 | | C04 | | C05 | | C06 | | C07 | | | | |C01=[[Heart]]|C02=[[CNS]]|C03=[[Eye]]|C04=[[Lung]]|C05=[[Bone]]|C06=[[Serosa]]|C07=[[Skin]]}}
 {{familytree | | | | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | | | |}}
-{{familytree | | | | | E01 | | E02 | | E03 | | E04 | | E05 | | E06 | | E07 | | | |
+{{familytree | | | | | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | D07 | | | | |D01=• Blood-culture negative [[endocarditis]]<br>• Adhesive [[pericarditis]]<br>• [[Myocardial fibrosis]]
-|E01=<div style="float: left; text-align: left>
+|D02=• [[Encephalitis]]<br>• Progressive [[dementia]]<br>• [[Cerebellar ataxia]]<br>• Personality changes<br>• [[Hemiparesis]]<br>• [[Seizure]]<br>• [[Wernicke’s encephalopathy]<br>• [[Hypothalamic]] involvement<br>• [[Supranuclear ophthalmoplegia]]|D03=• [[Uveitis]]<br>• [[Vitritis]]<br>• [[Retinitis]]<br>• [[Retrobulbar neuritis]]<br>• [[Papilledema]]|D04= |D05=• Arthritis<br>• Spondylodiscitis|D06=|D07=}}
-*Blood-culture negative [[endocarditis]]
-*Adhesive [[pericarditis]]
-*[[Myocardial fibrosis]]</div>
-|E02=<div style="float: left; text-align: left>
-*[[Encephalitis]]
-*Progressive [[dementia]]
-*[[Cerebellar ataxia]]
-*Personality changes
-*[[Hemiparesis]]
-*[[Seizure]]
-*[[Wernicke’s encephalopathy]
-*[[Hypothalamic]] involvement
-*[[Supranuclear ophthalmoplegia]]
-</div>
-|E03=<div style="float: left; text-align: left>
-*[[Uveitis]]
-*[[Vitritis]]
-*[[Retinitis]]
-*[[Retrobulbar neuritis]]
-*[[Papilledema]]
-</div>
-|E04= <div style="float: left; text-align: left>
-|E05=<div style="float: left; text-align: left>
-*Arthritis
-*Spondylodiscitis</div>
-|E06=<div style="float: left; text-align: left>
-</div>
-|E07=<div style="float: left; text-align: left>
-</div>}}
 {{familytree/end}}

Whipple's disease classification: Difference between revisions

Revision as of 19:40, 31 October 2017

Overview

Classification

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