Whipple's disease classification: Difference between revisions
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{{familytree | B01 | | | | | | | | | | | | | | B02 | | | | | | | | | | | | | | | | |B01=Systemic involvement|B02=Localized involvement}} | {{familytree | B01 | | | | | | | | | | | | | | B02 | | | | | | | | | | | | | | | | |B01=Systemic involvement|B02=Localized involvement}} | ||
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{{familytree | | | | | | {{familytree | | | C01 | | | C02 | | | C03 | | C04 | | C05 | | | C06 | | | C07 | | |C01=[[Heart]]|C02=[[CNS]]|C03=[[Eye]]|C04=[[Lung]]|C05=[[Bone]]|C06=[[Serosa]]|C07=[[Skin]]}} | ||
{{familytree | | | | | | | {{familytree | | | |!| | | | |!| | | | |!| | | |!| | | |!| | | | |!| | | | |!| | | |}} | ||
{{familytree |boxstyle=text-align: left; | | | | | {{familytree |boxstyle=text-align: left;| | D01 | | | D02 | | | D03 | | D04 | | D05 | | | D06 | | | D07 | | |D01=• Blood-culture negative [[endocarditis]]<br>• Adhesive [[pericarditis]]<br>• [[Myocardial fibrosis]] | ||
|D02=• [[Encephalitis]]<br>• Progressive [[dementia]]<br>• [[Cerebellar ataxia]]<br>• Personality changes<br>• [[Hemiparesis]]<br>• [[Seizure]]<br>• [[Wernicke’s encephalopathy]]<br>• [[Hypothalamic]] involvement<br>• [[Supranuclear ophthalmoplegia]]|D03=• [[Uveitis]]<br>• [[Vitritis]]<br>• [[Retinitis]]<br>• [[Retrobulbar neuritis]]<br>• [[Papilledema]]|D04=• [[Pleuritic chest pain]]<br>• Chronic nonproductive [[cough]]<br>• [[Dyspnea]]|D05=• [[Arthritis]]<br>• [[Spondylodiscitis]]|D06=• [[Pleuritic chest pain]]|D07=• [[Hyperpigmentation]]}} | |D02=• [[Encephalitis]]<br>• Progressive [[dementia]]<br>• [[Cerebellar ataxia]]<br>• Personality changes<br>• [[Hemiparesis]]<br>• [[Seizure]]<br>• [[Wernicke’s encephalopathy]]<br>• [[Hypothalamic]] involvement<br>• [[Supranuclear ophthalmoplegia]]|D03=• [[Uveitis]]<br>• [[Vitritis]]<br>• [[Retinitis]]<br>• [[Retrobulbar neuritis]]<br>• [[Papilledema]]|D04=• [[Pleuritic chest pain]]<br>• Chronic nonproductive [[cough]]<br>• [[Dyspnea]]|D05=• [[Arthritis]]<br>• [[Spondylodiscitis]]|D06=• [[Pleuritic chest pain]]|D07=• [[Hyperpigmentation]]}} | ||
{{familytree/end}} | {{familytree/end}} | ||
Revision as of 19:49, 31 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Whipple’s disease may be classified into 4 groups based on clinical manifestation: Acute infection, asymptomatic carrier state, the classic Whipple’s disease, and localized chronic infection.
Classification
- Whipple's disease may be classified to 2 groups of acute and chronic based on the duration.
- Whipple's disease may be classified to 2 groups of systemic and localized infection based on organ involvement.
- Tropheryma whipplei infection may be classified to 4 groups based on the clinical manifestation:[1][2]
- Acute infections such as:
- Asymptomatic carrier state
- The classic Whipple’s disease
- Localized involvement of different organs including:
Whipple's disease classification based on the duration
| Whipple's disease classification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Acute | Chronic | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gastroenteritis | Pneumonia | Bacteremia | Asymptomatic carrier state | Classic Whipple's disease | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Chronic localized infection | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Whipple's disease classification based on organ involvement
| Whipple's disease classification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Systemic involvement | Localized involvement | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Heart | CNS | Eye | Lung | Bone | Serosa | Skin | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| • Blood-culture negative endocarditis • Adhesive pericarditis • Myocardial fibrosis | • Encephalitis • Progressive dementia • Cerebellar ataxia • Personality changes • Hemiparesis • Seizure • Wernicke’s encephalopathy • Hypothalamic involvement • Supranuclear ophthalmoplegia | • Uveitis • Vitritis • Retinitis • Retrobulbar neuritis • Papilledema | • Pleuritic chest pain • Chronic nonproductive cough • Dyspnea | • Arthritis • Spondylodiscitis | • Pleuritic chest pain | • Hyperpigmentation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References
- ↑ Marth, Thomas (2009). "New Insights into Whipple's Disease – A Rare Intestinal Inflammatory Disorder". Digestive Diseases. 27 (4): 494–501. doi:10.1159/000233288. ISSN 1421-9875.
- ↑ Street, Sara; Donoghue, Helen D; Neild, GH (1999). "Tropheryma whippelii DNA in saliva of healthy people". The Lancet. 354 (9185): 1178–1179. doi:10.1016/S0140-6736(99)03065-2. ISSN 0140-6736.