Pyloric stenosis pathophysiology: Difference between revisions
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== Genetics == | == Genetics == | ||
In one study the familial recurrence pattern among monozygotic cotwins and more remote relatives of IHPS probands was found to be inconsistent with generalized single major locus inheritance. | In one study the familial recurrence pattern among monozygotic cotwins and more remote relatives of IHPS probands was found to be inconsistent with generalized single major locus inheritance.<ref name="pmid8237916">{{cite journal| author=Mitchell LE, Risch N| title=The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. | journal=Am J Dis Child | year= 1993 | volume= 147 | issue= 11 | pages= 1203-11 | pmid=8237916 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8237916 }} </ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
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Overview
Pathophysiology
The pathogenesis of infantile hypertrophic pyloric stenosis is not fully understood but it could be due abnormal innervation of the pyloric smooth muscle.
there are also some evidences of increased collagen production and abnormal amounts of extracellular matrix proteins in hypertrophic pyloric muscle.[1]
Genetics
In one study the familial recurrence pattern among monozygotic cotwins and more remote relatives of IHPS probands was found to be inconsistent with generalized single major locus inheritance.[2]
- ↑ Ohshiro K, Puri P (1998). "Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress". Pediatr Surg Int. 13 (4): 243–52. doi:10.1007/s003830050308. PMID 9553181.
- ↑ Mitchell LE, Risch N (1993). "The genetics of infantile hypertrophic pyloric stenosis. A reanalysis". Am J Dis Child. 147 (11): 1203–11. PMID 8237916.