Chronic pancreatitis causes: Difference between revisions

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*** Most common cause in men
*** Most common cause in men
*** Least common cause in women<ref name="pmid21029787">{{cite journal |vauthors=Coté GA, Yadav D, Slivka A, Hawes RH, Anderson MA, Burton FR, Brand RE, Banks PA, Lewis MD, Disario JA, Gardner TB, Gelrud A, Amann ST, Baillie J, Money ME, O'Connell M, Whitcomb DC, Sherman S |title=Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis |journal=Clin. Gastroenterol. Hepatol. |volume=9 |issue=3 |pages=266–73; quiz e27 |year=2011 |pmid=21029787 |pmc=3043170 |doi=10.1016/j.cgh.2010.10.015 |url=}}</ref>
*** Least common cause in women<ref name="pmid21029787">{{cite journal |vauthors=Coté GA, Yadav D, Slivka A, Hawes RH, Anderson MA, Burton FR, Brand RE, Banks PA, Lewis MD, Disario JA, Gardner TB, Gelrud A, Amann ST, Baillie J, Money ME, O'Connell M, Whitcomb DC, Sherman S |title=Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis |journal=Clin. Gastroenterol. Hepatol. |volume=9 |issue=3 |pages=266–73; quiz e27 |year=2011 |pmid=21029787 |pmc=3043170 |doi=10.1016/j.cgh.2010.10.015 |url=}}</ref>
**Tropical pancreatitis<ref name="pmid8200268">{{cite journal |vauthors=Sarles H, Augustine P, Laugier R, Mathew S, Dupuy P |title=Pancreatic lesions and modifications of pancreatic juice in tropical chronic pancreatitis (tropical calcific diabetes) |journal=Dig. Dis. Sci. |volume=39 |issue=6 |pages=1337–44 |year=1994 |pmid=8200268 |doi= |url=}}</ref><ref name="pmid12360463">{{cite journal |vauthors=Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H |title=Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations |journal=Gastroenterology |volume=123 |issue=4 |pages=1020–5 |year=2002 |pmid=12360463 |doi= |url=}}</ref><ref name="pmid12360464">{{cite journal |vauthors=Schneider A, Suman A, Rossi L, Barmada MM, Beglinger C, Parvin S, Sattar S, Ali L, Khan AK, Gyr N, Whitcomb DC |title=SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh |journal=Gastroenterology |volume=123 |issue=4 |pages=1026–30 |year=2002 |pmid=12360464 |doi= |url=}}</ref>
** Autoimmunity  
** Autoimmunity  
*** Autoimmune pancreatitis
*** Autoimmune pancreatitis

Revision as of 00:48, 2 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

The causes of pancreatitis are many but at least 70% of adult cases are associated with chronic alcohol use, and most patients have consumed more than 80 g/day of alcohol over six to twelve years.[1][2]

  • Major associations with chronic pancreatitis [3][4][5]
    • Alcohol[6][7][8][9][10][11]
      • ≥80 g of ethanol consumption a day for at least 5 years
      • Most common cause in men
      • Least common cause in women[12]
    • Tropical pancreatitis[13][14][15]
    • Autoimmunity
      • Autoimmune pancreatitis
      • Associated with other systemic disorders (Sjogren syndrome, inflammatory bowel disease, or primary biliary cholangitis)
    • Obstruction[16]
      • Fibrotic stenosis of either the papilla of Vater or the main pancreatic duct
      • Trauma
      • Pseudocysts
      • Stones
      • Tumors
      • Pancreas divisum[17] [18][19][20]
    • Anatomic variations
      • Pancreas divisum[17] [18][19][20]
      • Paraduodenal pancreatitis (Cystic dystrophy of the duodenal wall/groove pancreatitis[21])
    • Metabolic or systemic diseases
      • Hypercalcemia
      • Hypertryglyceridemia
      • Hyperparathyroidism
      • Systemic lupus erythematosus
    • Genetic
      • CFTR
      • CTRC
      • SPINK1
      • PRSS1 gene mutations
      • Hereditary pancreatitis[22]
    • Idiopathic

References

  1. ↑ Nair RJ, Lawler L, Miller MR (2007). "Chronic pancreatitis". Am Fam Physician. 76 (11): 1679–88. PMID 18092710.
  2. ↑ Mitchell RMS et al. Pancreatitis. Lancet 2003; 361: 1447–55
  3. ↑ Mitchell RMS et al. Pancreatitis. Lancet 2003; 361: 1447–55
  4. ↑ Frulloni et al. Chronic pancreatitis: Report from a multicenter Italian survey (PanCroInfAISP) on 893 patients. Dig Liver Dis. 2009 Apr;41(4):311-7
  5. ↑ Adsay NV et al. Paraduodenal pancreatitis: a clinico-pathologically distinct entity unifying "cystic dystrophy of heterotopic pancreas", "para-duodenal wall cyst", and "groove pancreatitis". Semin Diagn Pathol. 2004 Nov;21(4):247-54.
  6. ↑ Lu Z, Karne S, Kolodecik T, Gorelick FS (2002). "Alcohols enhance caerulein-induced zymogen activation in pancreatic acinar cells". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (3): G501–7. doi:10.1152/ajpgi.00388.2001. PMC 2830557. PMID 11842000.
  7. ↑ Bisceglie AM, Segal I (1984). "Cirrhosis and chronic pancreatitis in alcoholics". J. Clin. Gastroenterol. 6 (3): 199–200. PMID 6725910.
  8. ↑ Wilson JS, Bernstein L, McDonald C, Tait A, McNeil D, Pirola RC (1985). "Diet and drinking habits in relation to the development of alcoholic pancreatitis". Gut. 26 (9): 882–7. PMC 1432860. PMID 4029715.
  9. ↑ Whitcomb DC (2003). "Genetic predisposition to alcoholic chronic pancreatitis". Pancreas. 27 (4): 321–6. PMID 14576495.
  10. ↑ Maisonneuve P, Lowenfels AB, Müllhaupt B, Cavallini G, Lankisch PG, Andersen JR, Dimagno EP, Andrén-Sandberg A, Domellöf L, Frulloni L, Ammann RW (2005). "Cigarette smoking accelerates progression of alcoholic chronic pancreatitis". Gut. 54 (4): 510–4. doi:10.1136/gut.2004.039263. PMC 1774435. PMID 15753536.
  11. ↑ Morton C, Klatsky AL, Udaltsova N (2004). "Smoking, coffee, and pancreatitis". Am. J. Gastroenterol. 99 (4): 731–8. doi:10.1111/j.1572-0241.2004.04143.x. PMID 15089909.
  12. ↑ Coté GA, Yadav D, Slivka A, Hawes RH, Anderson MA, Burton FR, Brand RE, Banks PA, Lewis MD, Disario JA, Gardner TB, Gelrud A, Amann ST, Baillie J, Money ME, O'Connell M, Whitcomb DC, Sherman S (2011). "Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis". Clin. Gastroenterol. Hepatol. 9 (3): 266–73, quiz e27. doi:10.1016/j.cgh.2010.10.015. PMC 3043170. PMID 21029787.
  13. ↑ Sarles H, Augustine P, Laugier R, Mathew S, Dupuy P (1994). "Pancreatic lesions and modifications of pancreatic juice in tropical chronic pancreatitis (tropical calcific diabetes)". Dig. Dis. Sci. 39 (6): 1337–44. PMID 8200268.
  14. ↑ Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H (2002). "Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations". Gastroenterology. 123 (4): 1020–5. PMID 12360463.
  15. ↑ Schneider A, Suman A, Rossi L, Barmada MM, Beglinger C, Parvin S, Sattar S, Ali L, Khan AK, Gyr N, Whitcomb DC (2002). "SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh". Gastroenterology. 123 (4): 1026–30. PMID 12360464.
  16. ↑ Tarnasky PR, Hoffman B, Aabakken L, Knapple WL, Coyle W, Pineau B, Cunningham JT, Cotton PB, Hawes RH (1997). "Sphincter of Oddi dysfunction is associated with chronic pancreatitis". Am. J. Gastroenterol. 92 (7): 1125–9. PMID 9219783.
  17. ↑ 17.0 17.1 Lehman GA, Sherman S (1995). "Pancreas divisum. Diagnosis, clinical significance, and management alternatives". Gastrointest. Endosc. Clin. N. Am. 5 (1): 145–70. PMID 7728342.
  18. ↑ 18.0 18.1 Delhaye M, Engelholm L, Cremer M (1985). "Pancreas divisum: congenital anatomic variant or anomaly? Contribution of endoscopic retrograde dorsal pancreatography". Gastroenterology. 89 (5): 951–8. PMID 4043675.
  19. ↑ 19.0 19.1 Sherman S, Hawes RH, Savides TJ, Gress FG, Ikenberry SO, Smith MT, Zaidi S, Lehman GA (1996). "Stent-induced pancreatic ductal and parenchymal changes: correlation of endoscopic ultrasound with ERCP". Gastrointest. Endosc. 44 (3): 276–82. PMID 8885346.
  20. ↑ 20.0 20.1 Smith MT, Sherman S, Ikenberry SO, Hawes RH, Lehman GA (1996). "Alterations in pancreatic ductal morphology following polyethylene pancreatic stent therapy". Gastrointest. Endosc. 44 (3): 268–75. PMID 8885345.
  21. ↑ Tezuka K, Makino T, Hirai I, Kimura W (2010). "Groove pancreatitis". Dig Surg. 27 (2): 149–52. doi:10.1159/000289099. PMID 20551662.
  22. ↑ Sossenheimer MJ, Aston CE, Preston RA, Gates LK, Ulrich CD, Martin SP, Zhang Y, Gorry MC, Ehrlich GD, Whitcomb DC (1997). "Clinical characteristics of hereditary pancreatitis in a large family, based on high-risk haplotype. The Midwest Multicenter Pancreatic Study Group (MMPSG)". Am. J. Gastroenterol. 92 (7): 1113–6. PMID 9219780.


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