Diffuse esophageal spasm historical perspective: Difference between revisions
Jump to navigation
Jump to search
Madhu Sigdel (talk | contribs) No edit summary |
Madhu Sigdel (talk | contribs) No edit summary |
||
| Line 9: | Line 9: | ||
=== Discovery === | === Discovery === | ||
* DES was first described by Osgood, in 1889 in 6 patients who presented with chest pain and dysphagia. | * DES was first described by Osgood, in 1889 in 6 patients who presented with chest pain and dysphagia.<ref name="pmid24803878">{{cite journal| author=Achem SR| title=Diffuse esophageal spasm in the era of high-resolution manometry. | journal=Gastroenterol Hepatol (N Y) | year= 2014 | volume= 10 | issue= 2 | pages= 130-3 | pmid=24803878 | doi= | pmc=4011379 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24803878 }}</ref> | ||
* Creamer et al. (1958) made the first manometric descriptions of DES. | * Creamer et al. (1958) made the first manometric descriptions of DES.<ref name="pmid13538146">{{cite journal| author=CREAMER B, DONOGHUE E, CODE CF| title=Pattern of esophageal motility in diffuse spasm. | journal=Gastroenterology | year= 1958 | volume= 34 | issue= 5 | pages= 782-96 | pmid=13538146 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13538146 }}</ref> | ||
== Landmark Events in the Development of Treatment Strategies == | == Landmark Events in the Development of Treatment Strategies == | ||
Revision as of 01:32, 2 November 2017
|
Diffuse esophageal spasm Microchapters |
|
Differentiating Diffuse esophageal spasm from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Diffuse esophageal spasm historical perspective On the Web |
|
American Roentgen Ray Society Images of Diffuse esophageal spasm historical perspective |
|
Risk calculators and risk factors for Diffuse esophageal spasm historical perspective |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]
Overview
Historical Perspective
Historical Perspective
Discovery
- DES was first described by Osgood, in 1889 in 6 patients who presented with chest pain and dysphagia.[1]
- Creamer et al. (1958) made the first manometric descriptions of DES.[2]
Landmark Events in the Development of Treatment Strategies
- In 2000, development of high resolution esophageal manometry has led to classification of esophageal motility disorders.
Famous Cases
- The following are a few famous cases of disease name:
References
Pathophysiology
Pathogenesis
- The exact pathogenesis of DES is not fully understood. However, current high-resolution manometry studies suggest impairment of inhibitory myenteric plexus neuron. These neurons use nitric oxide (NO) as neurotransmitter. Hence, these patients may also have dysregulation of endogenous NO synthesis or/and degradation. The final result is premature and rapidly propagated or simultaneous contraction of smooth muscles of distal esophagus.
- ↑ Achem SR (2014). "Diffuse esophageal spasm in the era of high-resolution manometry". Gastroenterol Hepatol (N Y). 10 (2): 130–3. PMC 4011379. PMID 24803878.
- ↑ CREAMER B, DONOGHUE E, CODE CF (1958). "Pattern of esophageal motility in diffuse spasm". Gastroenterology. 34 (5): 782–96. PMID 13538146.