Pyloric stenosis pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
| Line 9: | Line 9: | ||
== Pathophysiology == | == Pathophysiology == | ||
The pathogenesis of infantile hypertrophic pyloric stenosis is not fully understood but it could be due abnormal innervation of the pyloric smooth muscle. | The [[pathogenesis]] of infantile hypertrophic pyloric stenosis is not fully understood but it could be due abnormal innervation of the pyloric [[smooth muscle]]. | ||
there are also some evidences of increased collagen production and abnormal amounts of extracellular matrix proteins in hypertrophic pyloric muscle.<ref name="pmid9553181">{{cite journal| author=Ohshiro K, Puri P| title=Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress. | journal=Pediatr Surg Int | year= 1998 | volume= 13 | issue= 4 | pages= 243-52 | pmid=9553181 | doi=10.1007/s003830050308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9553181 }} </ref> | there are also some evidences of increased [[collagen]] production and abnormal amounts of [[extracellular]] [[matrix]] proteins in hypertrophic pyloric [[muscle]].<ref name="pmid9553181">{{cite journal| author=Ohshiro K, Puri P| title=Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress. | journal=Pediatr Surg Int | year= 1998 | volume= 13 | issue= 4 | pages= 243-52 | pmid=9553181 | doi=10.1007/s003830050308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9553181 }} </ref> | ||
There is no known pathophysiology for adult-onset hypertrophic pyloric stenosis (HPS). | There is no known [[pathophysiology]] for adult-onset hypertrophic pyloric stenosis (HPS). | ||
== Genetics == | == Genetics == | ||
In one study the familial recurrence pattern among monozygotic cotwins and more remote relatives of IHPS probands was found to be inconsistent with generalized single major locus inheritance.<ref name="pmid8237916">{{cite journal| author=Mitchell LE, Risch N| title=The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. | journal=Am J Dis Child | year= 1993 | volume= 147 | issue= 11 | pages= 1203-11 | pmid=8237916 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8237916 }} </ref> | In one study the familial recurrence pattern among [[monozygotic]] cotwins and more remote relatives of IHPS probands was found to be inconsistent with generalized single major locus inheritance.<ref name="pmid8237916">{{cite journal| author=Mitchell LE, Risch N| title=The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. | journal=Am J Dis Child | year= 1993 | volume= 147 | issue= 11 | pages= 1203-11 | pmid=8237916 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8237916 }} </ref> | ||
== Associated Conditions of infantile hypertrophic pyloric stenosis == | == Associated Conditions of infantile hypertrophic pyloric stenosis == | ||
Revision as of 13:23, 3 November 2017
|
Pyloric stenosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Pyloric stenosis pathophysiology On the Web |
|
American Roentgen Ray Society Images of Pyloric stenosis pathophysiology |
|
Risk calculators and risk factors for Pyloric stenosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Overview
Pathophysiology
The pathogenesis of infantile hypertrophic pyloric stenosis is not fully understood but it could be due abnormal innervation of the pyloric smooth muscle.
there are also some evidences of increased collagen production and abnormal amounts of extracellular matrix proteins in hypertrophic pyloric muscle.[1]
There is no known pathophysiology for adult-onset hypertrophic pyloric stenosis (HPS).
Genetics
In one study the familial recurrence pattern among monozygotic cotwins and more remote relatives of IHPS probands was found to be inconsistent with generalized single major locus inheritance.[2]
Associated Conditions of infantile hypertrophic pyloric stenosis
- Neuromuscular disorders
- Connective tissue disorders
- Metabolic disorders
- Intracellular signalling pathway disturbances
- Intercellular communication disturbances
- Ciliopathies
- DNA-repair disturbances
- Transcription regulation disorders
- MAPK-pathway disturbances
- Lymphatic abnormalities
- Environmental factors[3]
References
- ↑ Ohshiro K, Puri P (1998). "Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress". Pediatr Surg Int. 13 (4): 243–52. doi:10.1007/s003830050308. PMID 9553181.
- ↑ Mitchell LE, Risch N (1993). "The genetics of infantile hypertrophic pyloric stenosis. A reanalysis". Am J Dis Child. 147 (11): 1203–11. PMID 8237916.
- ↑ Peeters B, Benninga MA, Hennekam RC (2012). "Infantile hypertrophic pyloric stenosis--genetics and syndromes". Nat Rev Gastroenterol Hepatol. 9 (11): 646–60. doi:10.1038/nrgastro.2012.133. PMID 22777173.