Budd-Chiari syndrome laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
When Budd-Chiari syndrome is suspected, measurements are made of | When Budd-Chiari syndrome is suspected, measurements are made of : | ||
* [[Liver enzyme]] levels | * [[Liver enzyme]] levels | ||
| Line 17: | Line 17: | ||
* [[Liver biopsy]] is nonspecific but sometimes necessary to differentiate between Budd-Chiari syndrome and other causes of hepatomegaly and ascites, such as [[galactosemia]] or [[Reye's syndrome]] | * [[Liver biopsy]] is nonspecific but sometimes necessary to differentiate between Budd-Chiari syndrome and other causes of hepatomegaly and ascites, such as [[galactosemia]] or [[Reye's syndrome]] | ||
* Severe hepatic [[necrosis]] and [[lactic acidosis]] may be present as well. Caudate lobe hypertrophy is often present. The majority of patients have a slower-onset form of Budd-Chiari syndrome. This can be painless. Patients may progress to [[cirrhosis]] and show the signs of liver failure. | * Severe hepatic [[necrosis]] and [[lactic acidosis]] may be present as well. Caudate lobe hypertrophy is often present. The majority of patients have a slower-onset form of Budd-Chiari syndrome. This can be painless. Patients may progress to [[cirrhosis]] and show the signs of liver failure. | ||
*Laboratory findings consistent with the diagnosis of acute and fulminant BCS include: | |||
**Elevated Serum aspartate and alanine aminotransferase levels may be more than five times the upper limit of the normal range. | |||
**Elevated Serum alkaline phosphatase and bilirubin levels, decreased serum albumin level. | |||
**Ascitic fluid examination shows: | |||
**Total protein level more than 2.5 g per deciliter | |||
**White blood cells are usually less than 500/μL. | |||
**Additional Hematological tests are recommended to evaluate for hypercoagulability. | |||
==References== | ==References== | ||
Revision as of 19:10, 6 November 2017
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Overview
Laboratory Findings
When Budd-Chiari syndrome is suspected, measurements are made of :
- Liver enzyme levels
- Creatinine
- Urea
- Electrolytes
- LDH
- Liver biopsy is nonspecific but sometimes necessary to differentiate between Budd-Chiari syndrome and other causes of hepatomegaly and ascites, such as galactosemia or Reye's syndrome
- Severe hepatic necrosis and lactic acidosis may be present as well. Caudate lobe hypertrophy is often present. The majority of patients have a slower-onset form of Budd-Chiari syndrome. This can be painless. Patients may progress to cirrhosis and show the signs of liver failure.
- Laboratory findings consistent with the diagnosis of acute and fulminant BCS include:
- Elevated Serum aspartate and alanine aminotransferase levels may be more than five times the upper limit of the normal range.
- Elevated Serum alkaline phosphatase and bilirubin levels, decreased serum albumin level.
- Ascitic fluid examination shows:
- Total protein level more than 2.5 g per deciliter
- White blood cells are usually less than 500/μL.
- Additional Hematological tests are recommended to evaluate for hypercoagulability.