Peptic ulcer disease endoscopy: Difference between revisions

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==Endoscopic therapy==
==Endoscopic therapy==
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Revision as of 17:42, 7 November 2017

Endoscopic therapy

Indications for endoscopic therapy

  • Patients with active spurting or oozing bleeding or a non-bleeding visible vessel[1]


 
 
 
Active bleeding or non bleeding visible vessel
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Endoscopic therapy
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
IV PPI bolus +infusions
 
 
 


  • Patients with an adherent clot resistant to vigorous irrigation


 
 
 
Adherent clot
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Endoscopic therapy
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
IV PPI bolus +infusions
 
 
 

Endoscopic therapy can be done by following methods:[2]

  • Injection therapy:
    • Injection of diluted epinephrine (1:10,000) is commonly used[3]
    • injection of sclerosant (eg polidocanol, ethanolamine, and ethanol), fibrin sealant, and n-butyl cyanoacrylate[4][5]
  • Thermal coagulation:
    • Contact types -heater probe, monopolar and bipolar electrocoagulation
    • Noncontact types -laser treatment, argon plasma coagulation [APC][6]
  • Mechanical Devices-Endooclips are used commonly[7][8]
  • Combined Therapy-injection of diluted epinephrine followed by thermal coagulation[6]

Endoscopic therapy

 
 
 
Active bleeding or non bleeding visible vessel
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Endoscopic therapy
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
IV PPI bolus +infusions
 
 
 


Second look endoscopy

  • Second look endoscopy is used to detect and retreat ulcers that are at risk of recurrent bleeding which reduces the number of episodes of recurrent bleeding and hence decrease the surgery necessary to treat recurrent bleeding[9][10]
  • It is usually done after 24 hours.

If bleeding occurs after a second endoscopic therapeutic session, surgery or interventional radiology with transcatheter arterial embolization is done.

References

  1. Laine L, McQuaid KR (2009). "Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials". Clin. Gastroenterol. Hepatol. 7 (1): 33–47, quiz 1–2. doi:10.1016/j.cgh.2008.08.016. PMID 18986845.
  2. Cook DJ, Guyatt GH, Salena BJ, Laine LA (1992). "Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis". Gastroenterology. 102 (1): 139–48. PMID 1530782.
  3. Park CH, Lee SJ, Park JH, Park JH, Lee WS, Joo YE, Kim HS, Choi SK, Rew JS, Kim SJ (2004). "Optimal injection volume of epinephrine for endoscopic prevention of recurrent peptic ulcer bleeding". Gastrointest. Endosc. 60 (6): 875–80. PMID 15605000.
  4. Rutgeerts P, Rauws E, Wara P, Swain P, Hoos A, Solleder E, Halttunen J, Dobrilla G, Richter G, Prassler R (1997). "Randomised trial of single and repeated fibrin glue compared with injection of polidocanol in treatment of bleeding peptic ulcer". Lancet. 350 (9079): 692–6. PMID 9291903.
  5. Chung SC, Leong HT, Chan AC, Lau JY, Yung MY, Leung JW, Li AK (1996). "Epinephrine or epinephrine plus alcohol for injection of bleeding ulcers: a prospective randomized trial". Gastrointest. Endosc. 43 (6): 591–5. PMID 8781939.
  6. 6.0 6.1 Lin HJ, Tseng GY, Perng CL, Lee FY, Chang FY, Lee SD (1999). "Comparison of adrenaline injection and bipolar electrocoagulation for the arrest of peptic ulcer bleeding". Gut. 44 (5): 715–9. PMC 1727515. PMID 10205211.
  7. Ohta S, Yukioka T, Ohta S, Miyagatani Y, Matsuda H, Shimazaki S (1996). "Hemostasis with endoscopic hemoclipping for severe gastrointestinal bleeding in critically ill patients". Am. J. Gastroenterol. 91 (4): 701–4. PMID 8677932.
  8. Scapa E (1997). "Treating gastrointestinal bleeding with endoscopic hemoclips". Surg Laparosc Endosc. 7 (2): 94–6. PMID 9109234.
  9. Chiu PW, Lam CY, Lee SW, Kwong KH, Lam SH, Lee DT, Kwok SP (2003). "Effect of scheduled second therapeutic endoscopy on peptic ulcer rebleeding: a prospective randomised trial". Gut. 52 (10): 1403–7. PMC 1773815. PMID 12970130.
  10. Villanueva C, Balanzó J, Torras X, Soriano G, Sáinz S, Vilardell F (1994). "Value of second-look endoscopy after injection therapy for bleeding peptic ulcer: a prospective and randomized trial". Gastrointest. Endosc. 40 (1): 34–9. PMID 8163132.