Whipple's disease other diagnostic studies: Difference between revisions
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{{CMG}}; {{AE}} {{BHA}} | {{CMG}}; {{AE}} {{BHA}} | ||
==Overview== | ==Overview== | ||
Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. | [[Small bowel]] [[biopsy]] may be helpful in the diagnosis of Whipple's disease. Diagnostic findings of Whipple's disease include, [[PAS stain|PAS]] positive [[inclusions]] in [[macrophages]] of [[lamina propria]]. Other diagnostic studies for Whipple's disease include [[electron microscopy]] which demonstrate [[bacteria]], [[immunofluorescent]] assay to detect [[antibodies]] against [[Tropheryma whipplei]] and [[PCR]], which demonstrates 16S [[rRNA]] gene of [[Tropheryma whipplei]]. | ||
Other diagnostic studies for | |||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
Revision as of 21:12, 9 November 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Bhagyashree Deshmankar M.B.B.S.[2]
Overview
Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Diagnostic findings of Whipple's disease include, PAS positive inclusions in macrophages of lamina propria. Other diagnostic studies for Whipple's disease include electron microscopy which demonstrate bacteria, immunofluorescent assay to detect antibodies against Tropheryma whipplei and PCR, which demonstrates 16S rRNA gene of Tropheryma whipplei.
Other Diagnostic Studies
- Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of Whipple's disease include:[1]
- PAS positive inclusions in macrophages of lamina propria.
- All the organs affected by disease may demostrate PAS-positive macrophages like heart, lungs, CNS , eyes, liver, spleen, joints, and bone marrow.
- Other diagnostic studies for Whipple's disease which confirm the diagnosis include:
- Electron Microscopy, which demonstrates:[1]
- typical trilamellar membrane of T. Whippleii.
- gram positive cell wall structure
- PCR of affected tissue which demonstrates:
- 16S rRNA gene of T. Whipplei
- Immunofluoroscent assay of serum of patients with Whipple's disease which demonstrates:[1]
- Antibodies against T. Whippleii in patients' serum.