Whipple's disease other diagnostic studies: Difference between revisions
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{{Whipple's disease}} | |||
{{CMG}}; {{AE}} {{BHA}} | {{CMG}}; {{AE}} {{BHA}}; {{SSH}} | ||
==Overview== | ==Overview== | ||
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**[[PAS stain|PAS]] positive [[inclusions]] in [[macrophages]] of [[lamina propria]] | **[[PAS stain|PAS]] positive [[inclusions]] in [[macrophages]] of [[lamina propria]] | ||
**All the organs affected by disease may demonstrate [[Periodic acid-Schiff stain|PAS]] positive [[macrophages]] like [[heart]], [[lungs]], [[CNS]], [[eyes]], [[liver]], [[spleen]], [[joints]], and [[bone marrow]]. | **All the organs affected by disease may demonstrate [[Periodic acid-Schiff stain|PAS]] positive [[macrophages]] like [[heart]], [[lungs]], [[CNS]], [[eyes]], [[liver]], [[spleen]], [[joints]], and [[bone marrow]]. | ||
* Other diagnostic studies for [[Whipple's disease]] which confirm the diagnosis include: | * Other diagnostic studies for [[Whipple's disease]] which confirm the diagnosis include: | ||
**[[Electron microscopy]], which demonstrates: | **[[Electron microscopy]], which demonstrates: | ||
***Typical trilamellar [[membrane]] of [[Tropheryma whipplei]] | ***Typical trilamellar [[membrane]] of [[Tropheryma whipplei]] | ||
***Gram positive cell wall structure | ***Gram positive cell wall structure | ||
**[[PCR]] of affected tissue, which demonstrates: | **[[PCR]] of affected tissue, which demonstrates: | ||
***16S [[rRNA]] gene of [[Tropheryma whipplei]] | ***16S [[rRNA]] gene of [[Tropheryma whipplei]] | ||
** Serum [[immunofluorescent]] assay, which demonstrates: | ** Serum [[immunofluorescent]] assay, which demonstrates: | ||
***[[Antibodies]] against [[Tropheryma whipplei]] | ***[[Antibodies]] against [[Tropheryma whipplei]] | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 21:19, 9 November 2017
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Whipple's disease Microchapters |
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Diagnosis |
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Treatment |
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Whipple's disease other diagnostic studies On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Bhagyashree Deshmankar M.B.B.S.[2]; Sadaf Sharfaei M.D.[3]
Overview
Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Diagnostic findings of Whipple's disease include, PAS positive inclusions in macrophages of lamina propria. Other diagnostic studies for Whipple's disease include electron microscopy which demonstrate bacteria, immunofluorescent assay to detect antibodies against Tropheryma whipplei and PCR, which demonstrates 16S rRNA gene of Tropheryma whipplei.
Other Diagnostic Studies
- Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of Whipple's disease include:[1]
- PAS positive inclusions in macrophages of lamina propria
- All the organs affected by disease may demonstrate PAS positive macrophages like heart, lungs, CNS, eyes, liver, spleen, joints, and bone marrow.
- Other diagnostic studies for Whipple's disease which confirm the diagnosis include:
- Electron microscopy, which demonstrates:
- Typical trilamellar membrane of Tropheryma whipplei
- Gram positive cell wall structure
- PCR of affected tissue, which demonstrates:
- 16S rRNA gene of Tropheryma whipplei
- Serum immunofluorescent assay, which demonstrates:
- Antibodies against Tropheryma whipplei
- Electron microscopy, which demonstrates:
References
- ↑ Dutly, F.; Altwegg, M. (2001). "Whipple's Disease and "Tropheryma whippelii"". Clinical Microbiology Reviews. 14 (3): 561–583. doi:10.1128/CMR.14.3.561-583.2001. ISSN 0893-8512.