Whipple's disease classification: Difference between revisions
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==Classification== | ==Classification== | ||
*Whipple's disease may be classified to 2 groups of acute and chronic based on the duration. | *Whipple's disease may be classified to 2 groups of [[acute]] and [[chronic]] based on the duration. | ||
*Whipple's disease may be classified to 2 groups of systemic and localized [[infection]] based on [[organ]] involvement. | *Whipple's disease may be classified to 2 groups of [[systemic]] and localized [[infection]] based on [[Organ (biology)|organ]] involvement. | ||
*[[Tropheryma whipplei]] infection may be classified to 4 groups based on the clinical manifestation:<ref name="Marth2009">{{cite journal|last1=Marth|first1=Thomas|title=New Insights into Whipple’s Disease – A Rare Intestinal Inflammatory Disorder|journal=Digestive Diseases|volume=27|issue=4|year=2009|pages=494–501|issn=1421-9875|doi=10.1159/000233288}}</ref><ref name="StreetDonoghue1999">{{cite journal|last1=Street|first1=Sara|last2=Donoghue|first2=Helen D|last3=Neild|first3=GH|title=Tropheryma whippelii DNA in saliva of healthy people|journal=The Lancet|volume=354|issue=9185|year=1999|pages=1178–1179|issn=01406736|doi=10.1016/S0140-6736(99)03065-2}}</ref> | *[[Tropheryma whipplei]] [[infection]] may be classified to 4 groups based on the [[clinical]] manifestation:<ref name="Marth2009">{{cite journal|last1=Marth|first1=Thomas|title=New Insights into Whipple’s Disease – A Rare Intestinal Inflammatory Disorder|journal=Digestive Diseases|volume=27|issue=4|year=2009|pages=494–501|issn=1421-9875|doi=10.1159/000233288}}</ref><ref name="StreetDonoghue1999">{{cite journal|last1=Street|first1=Sara|last2=Donoghue|first2=Helen D|last3=Neild|first3=GH|title=Tropheryma whippelii DNA in saliva of healthy people|journal=The Lancet|volume=354|issue=9185|year=1999|pages=1178–1179|issn=01406736|doi=10.1016/S0140-6736(99)03065-2}}</ref> | ||
**Acute infections such as: | **[[Acute]] [[infections]] such as: | ||
***[[Gastroenteritis]] | ***[[Gastroenteritis]] | ||
***[[Bacteremia]] | ***[[Bacteremia]] | ||
***[[Pneumonia]] | ***[[Pneumonia]] | ||
**Asymptomatic carrier state | **[[Asymptomatic carrier]] state | ||
**The classic Whipple’s disease | **The classic Whipple’s disease | ||
**Localized involvement of different organs including: | **Localized involvement of different [[organs]] including: | ||
***[[Heart]]: | ***[[Heart]]: | ||
****Blood-culture negative [[endocarditis]] | ****[[Blood culture|Blood-culture]] negative [[endocarditis]] | ||
****Adhesive [[pericarditis]] | ****Adhesive [[pericarditis]] | ||
****[[Myocardial]] [[fibrosis]] | ****[[Myocardial]] [[fibrosis]] | ||
Revision as of 15:49, 10 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Whipple’s disease may be classified into 2 groups of acute and chronic infection. It might be classified as systemic or localized based on the organ involvement. It has 4 different clinical manifestations: Acute infection, asymptomatic carrier state, the classic Whipple’s disease, and localized chronic infection.
Classification
- Whipple's disease may be classified to 2 groups of acute and chronic based on the duration.
- Whipple's disease may be classified to 2 groups of systemic and localized infection based on organ involvement.
- Tropheryma whipplei infection may be classified to 4 groups based on the clinical manifestation:[1][2]
- Acute infections such as:
- Asymptomatic carrier state
- The classic Whipple’s disease
- Localized involvement of different organs including:
- Heart:
- Blood-culture negative endocarditis
- Adhesive pericarditis
- Myocardial fibrosis
- CNS:
- Eyes:
- Uveitis
- Vitritis
- Retinitis
- Retrobulbar neuritis
- Papilledema
- Lung:
- Bone:
- Serosa:
- Skin:
- Heart:
Whipple's disease classification based on the duration
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Whipple's disease classification based on organ involvement
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References
- ↑ Marth, Thomas (2009). "New Insights into Whipple's Disease – A Rare Intestinal Inflammatory Disorder". Digestive Diseases. 27 (4): 494–501. doi:10.1159/000233288. ISSN 1421-9875.
- ↑ Street, Sara; Donoghue, Helen D; Neild, GH (1999). "Tropheryma whippelii DNA in saliva of healthy people". The Lancet. 354 (9185): 1178–1179. doi:10.1016/S0140-6736(99)03065-2. ISSN 0140-6736.