Whipple's disease classification: Difference between revisions
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{{familytree | | | | | | | | | B01 | | | | | | | | B02 | | | | | | |B01=Acute|B02=Chronic}} | {{familytree | | | | | | | | | B01 | | | | | | | | B02 | | | | | | |B01=Acute|B02=Chronic}} | ||
{{familytree | | | | | |,|-|-|-|+|-|-|-|.| | | |,|-|+|-|.| | | | | |}} | {{familytree | | | | | |,|-|-|-|+|-|-|-|.| | | |,|-|+|-|.| | | | | |}} | ||
{{familytree | | | | | C01 | | C02 | | C03 | | C04 |!| C05 | | | | |C01=[[Gastroenteritis]]|C02=[[Pneumonia]]|C03=[[Bacteremia]]|C04=Asymptomatic carrier state|C05=Classic Whipple's disease}} | {{familytree | | | | | C01 | | C02 | | C03 | | C04 |!| C05 | | | | |C01=[[Gastroenteritis]]|C02=[[Pneumonia]]|C03=[[Bacteremia]]|C04=[[Asymptomatic carrier]] state|C05=Classic Whipple's disease}} | ||
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{{familytree | | | | | | | | | | | | | | | | | | | D01 | | | | | | |D01=Chronic localized infection}} | {{familytree | | | | | | | | | | | | | | | | | | | D01 | | | | | | |D01=[[Chronic]] localized [[infection]]}} | ||
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'''Whipple's disease classification based on organ involvement''' | '''Whipple's disease classification based on [[organ]] involvement''' | ||
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{{familytree | | | | | C01 | | C02 | | C03 | | C04 | | C05 | | C06 | | C07 | | |C01=[[Heart]]|C02=[[CNS]]|C03=[[Eye]]|C04=[[Lung]]|C05=[[Bone]]|C06=[[Serosa]]|C07=[[Skin]]}} | {{familytree | | | | | C01 | | C02 | | C03 | | C04 | | C05 | | C06 | | C07 | | |C01=[[Heart]]|C02=[[CNS]]|C03=[[Eye]]|C04=[[Lung]]|C05=[[Bone]]|C06=[[Serosa]]|C07=[[Skin]]}} | ||
{{familytree | | | | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |}} | {{familytree | | | | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |}} | ||
{{familytree |boxstyle=text-align: left;| | | | | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | D07 | | |D01=• Blood | {{familytree |boxstyle=text-align: left;| | | | | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | D07 | | |D01=• [[Blood culture]] negative [[endocarditis]]<br>• Adhesive [[pericarditis]]<br>• [[Myocardial fibrosis]] | ||
|D02=• [[Encephalitis]]<br>• Progressive [[dementia]]<br>• [[Cerebellar ataxia]]<br>• Personality changes<br>• [[Hemiparesis]]<br>• [[Seizure]]<br>• [[Wernicke’s encephalopathy]]<br>• [[Hypothalamic]] involvement<br>• [[Supranuclear ophthalmoplegia]]|D03=• [[Uveitis]]<br>• [[Vitritis]]<br>• [[Retinitis]]<br>• [[Retrobulbar neuritis]]<br>• [[Papilledema]]|D04=• Chronic [[cough]]<br>• [[Dyspnea]]|D05=• [[Arthritis]]<br>• [[Spondylodiscitis]]|D06=• [[Pleuritic chest pain]]|D07=• [[Hyperpigmentation]]}} | |D02=• [[Encephalitis]]<br>• Progressive [[dementia]]<br>• [[Cerebellar ataxia]]<br>• [[Personality changes]]<br>• [[Hemiparesis]]<br>• [[Seizure]]<br>• [[Wernicke’s encephalopathy]]<br>• [[Hypothalamic]] involvement<br>• [[Supranuclear ophthalmoplegia]]|D03=• [[Uveitis]]<br>• [[Vitritis]]<br>• [[Retinitis]]<br>• [[Retrobulbar neuritis]]<br>• [[Papilledema]]|D04=• Chronic [[cough]]<br>• [[Dyspnea]]|D05=• [[Arthritis]]<br>• [[Spondylodiscitis]]|D06=• [[Pleuritic chest pain]]|D07=• [[Hyperpigmentation]]}} | ||
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Revision as of 15:53, 10 November 2017
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Whipple's disease Microchapters |
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Whipple's disease classification On the Web |
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American Roentgen Ray Society Images of Whipple's disease classification |
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Risk calculators and risk factors for Whipple's disease classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Whipple’s disease may be classified into 2 groups of acute and chronic infection. It might be classified as systemic or localized based on the organ involvement. It has 4 different clinical manifestations: Acute infection, asymptomatic carrier state, the classic Whipple’s disease, and localized chronic infection.
Classification
- Whipple's disease may be classified to 2 groups of acute and chronic based on the duration.[1]
- Whipple's disease may be classified to 2 groups of systemic and localized infection based on organ involvement.[2]
- Tropheryma whipplei infection may be classified to 4 groups based on the clinical manifestation:[1][3]
- Acute infections such as:
- Asymptomatic carrier state
- The classic Whipple’s disease
- Localized involvement of different organs including:
- Heart:
- Blood-culture negative endocarditis
- Adhesive pericarditis
- Myocardial fibrosis
- CNS:
- Eyes:
- Uveitis
- Vitritis
- Retinitis
- Retrobulbar neuritis
- Papilledema
- Lung:
- Bone:
- Serosa:
- Skin:
- Heart:
Whipple's disease classification based on the duration
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Whipple's disease classification based on organ involvement
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References
- ↑ 1.0 1.1 Marth, Thomas (2009). "New Insights into Whipple's Disease – A Rare Intestinal Inflammatory Disorder". Digestive Diseases. 27 (4): 494–501. doi:10.1159/000233288. ISSN 1421-9875.
- ↑ Relman, David A.; Schmidt, Thomas M.; MacDermott, Richard P.; Falkow, Stanley (1992). "Identification of the Uncultured Bacillus of Whipple's Disease". New England Journal of Medicine. 327 (5): 293–301. doi:10.1056/NEJM199207303270501. ISSN 0028-4793.
- ↑ Street, Sara; Donoghue, Helen D; Neild, GH (1999). "Tropheryma whippelii DNA in saliva of healthy people". The Lancet. 354 (9185): 1178–1179. doi:10.1016/S0140-6736(99)03065-2. ISSN 0140-6736.