Peptic ulcer causes: Difference between revisions
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===Causes by Organ System=== | ===Causes by Organ System=== | ||
{|style="width:80%; height:100px" border="1" | {| style="width:80%; height:100px" border="1" | ||
| | | style="width:25%" bgcolor="LightSteelBlue" ; border="1" | '''Cardiovascular''' | ||
| | | style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Chemical / poisoning''' | | '''Chemical / poisoning''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Dermatologic''' | | '''Dermatologic''' | ||
|bgcolor="Beige"| [[Rosacea]],Chronic idiopathic [[urticaria]] ,[[Psoriasis|Psoriasis vulgaris]] ,[[Behçet's disease|Behcet's disease]] ,[[Alopecia areata]],[[Sweet's syndrome]] <ref name="pmid25045884">{{cite journal| author=Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E et al.| title=Helicobacter pylori infection and skin disorders. | journal=Hong Kong Med J | year= 2014 | volume= 20 | issue= 4 | pages= 317-24 | pmid=25045884 | doi=10.12809/hkmj134174 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25045884 }} </ref> | | bgcolor="Beige" | [[Rosacea]],Chronic idiopathic [[urticaria]] ,[[Psoriasis|Psoriasis vulgaris]] ,[[Behçet's disease|Behcet's disease]] ,[[Alopecia areata]],[[Sweet's syndrome]] <ref name="pmid25045884">{{cite journal| author=Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E et al.| title=Helicobacter pylori infection and skin disorders. | journal=Hong Kong Med J | year= 2014 | volume= 20 | issue= 4 | pages= 317-24 | pmid=25045884 | doi=10.12809/hkmj134174 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25045884 }} </ref> | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
|bgcolor="Beige"| [[Aceclofenac]], [[Acemetacin]], [[Alendronate]], [[Artemether and lumefantrin]], [[Aspirin]], [[Azapropazone]], [[Benoxaprofen]], [[Bisphosphonates]], [[Carbinoxamine]], [[Celecoxib]], [[Clopidogrel]], [[Dexamethasone]], [[Diclofenac]], [[Diflunisal]], [[Ethanol]], [[ethanolamine oleate]], [[Etidronic acid]], [[Etodolac]], [[Etoricoxib]], [[Febuxostat]], [[Fenbufen]], [[Fenoprofen]], [[Flurbiprofen]], [[Glucocorticoids]], [[Hydrocortisone]], [[Ibuprofen]], [[Indomethacin]], [[Ketoprofen]], [[Laxative abuse]], [[Mefenamic acid]], [[Meloxicam]], [[Mepenzolate bromide]], [[Methylprednisolone]], [[Nabumetone]], [[Naproxen]], [[Naproxen and esomeprazole magnesium]], [[Niacin]], [[Non steroidal anti-inflammatory drugs]], [[Oxcarbazepine]], [[Para-amino salicylic acid]], [[Pergolide]], [[Phenylbutazone]], [[Pramipexole]], [[Piroxicam]], [[Pramipexole]], [[Prednisolone]], [[Prednisone]], [[Rofecoxib]], [[Sertraline]], [[Sulindac]], [[Tacrolimus]], [[Tenoxicam]], [[Tiaprofenic acid]], [[Tocilizumab]], [[Tolazoline]], [[Tolmetin]], [[Trimetrexate]] | | bgcolor="Beige" | [[Aceclofenac]], [[Acemetacin]], [[Alendronate]], [[Artemether and lumefantrin]], [[Aspirin]], [[Azapropazone]], [[Benoxaprofen]], [[Bisphosphonates]], [[Carbinoxamine]], [[Celecoxib]], [[Clopidogrel]], [[Dexamethasone]], [[Diclofenac]], [[Diflunisal]], [[Ethanol]], [[ethanolamine oleate]], [[Etidronic acid]], [[Etodolac]], [[Etoricoxib]], [[Febuxostat]], [[Fenbufen]], [[Fenoprofen]], [[Flurbiprofen]], [[Glucocorticoids]], [[Hydrocortisone]], [[Ibuprofen]], [[Indomethacin]], [[Ketoprofen]], [[Laxative abuse]], [[Mefenamic acid]], [[Meloxicam]], [[Mepenzolate bromide]], [[Methylprednisolone]], [[Nabumetone]], [[Naproxen]], [[Naproxen and esomeprazole magnesium]], [[Niacin]], [[Non steroidal anti-inflammatory drugs]], [[Oxcarbazepine]], [[Para-amino salicylic acid]], [[Pergolide]], [[Phenylbutazone]], [[Pramipexole]], [[Piroxicam]], [[Pramipexole]], [[Prednisolone]], [[Prednisone]], [[Rofecoxib]], [[Sertraline]], [[Sulindac]], [[Tacrolimus]], [[Tenoxicam]], [[Tiaprofenic acid]], [[Tocilizumab]], [[Tolazoline]], [[Tolmetin]], [[Trimetrexate]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Ear Nose Throat''' | | '''Ear Nose Throat''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Endocrine''' | | '''Endocrine''' | ||
|bgcolor="Beige"| [[Cushing syndrome]], [[Multiple endocrine neoplasia type 1]], [[Zollinger-Ellison syndrome]], [[Hyperparathyroidism|primary hyperparathyroidism]] | | bgcolor="Beige" | [[Cushing syndrome]], [[Multiple endocrine neoplasia type 1]], [[Zollinger-Ellison syndrome]], [[Hyperparathyroidism|primary hyperparathyroidism]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Environmental''' | | '''Environmental''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Gastroenterologic''' | | '''Gastroenterologic''' | ||
|bgcolor="Beige"| [[Crohn disease]], [[Cushing ulcers]], [[Dieulafoy's lesion]], [[Duodenal ulcer]], [[Eosinophilic gastroenteritis]], [[Gastric ulcer]], [[Oesophagitis]], [[Zollinger-Ellison syndrome]], [[Carcinoid tumours and carcinoid syndrome]], [[Stomach cancer]], [[Curling ulcers]] | | bgcolor="Beige" | [[Crohn disease]], [[Cushing ulcers]], [[Dieulafoy's lesion]], [[Duodenal ulcer]], [[Eosinophilic gastroenteritis]], [[Gastric ulcer]], [[Oesophagitis]], [[Zollinger-Ellison syndrome]], [[Carcinoid tumours and carcinoid syndrome]], [[Stomach cancer]], [[Curling ulcers]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Genetic''' | | '''Genetic''' | ||
|bgcolor="Beige"| [[Zollinger -Ellison syndrome]] associated with [[MEN TYPE 1]] syndrome caused by mutation in MEN gene present on chromosome 11q 13 | | bgcolor="Beige" | [[Zollinger -Ellison syndrome]] associated with [[MEN TYPE 1]] syndrome caused by mutation in MEN gene present on chromosome 11q 13 | ||
|- | |- | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Hematologic''' | | '''Hematologic''' | ||
|bgcolor="Beige"| [[Mastocytosis]], [[Polycythaemia rubra vera]], [[Primary thrombocythemia]] | | bgcolor="Beige" | [[Mastocytosis]], [[Polycythaemia rubra vera]], [[Primary thrombocythemia]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Iatrogenic''' | | '''Iatrogenic''' | ||
|bgcolor="Beige"| [[Mechanical ventilation]] | | bgcolor="Beige" | [[Mechanical ventilation]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Infectious Disease''' | | '''Infectious Disease''' | ||
|bgcolor="Beige"| [[Helicobacter pylori]] | | bgcolor="Beige" | [[Helicobacter pylori]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Musculoskeletal / Ortho''' | | '''Musculoskeletal / Ortho''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Neurologic''' | | '''Neurologic''' | ||
|bgcolor="Beige"| [[Cushing ulcers]] | | bgcolor="Beige" | [[Cushing ulcers]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Nutritional / Metabolic''' | | '''Nutritional / Metabolic''' | ||
|bgcolor="Beige"| [[Hypercalcaemia]] | | bgcolor="Beige" | [[Hypercalcaemia]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Obstetric/Gynecologic''' | | '''Obstetric/Gynecologic''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Oncologic''' | | '''Oncologic''' | ||
|bgcolor="Beige"| [[Carcinoid tumours and carcinoid syndrome]], [[Stomach cancer]], [[Zollinger-Ellison syndrome]] | | bgcolor="Beige" | [[Carcinoid tumours and carcinoid syndrome]], [[Stomach cancer]], [[Zollinger-Ellison syndrome|Zollinger-Ellison syndrome ,]] [[gastrinomas]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Opthalmologic''' | | '''Opthalmologic''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Overdose / Toxicity''' | | '''Overdose / Toxicity''' | ||
|bgcolor="Beige"| [[Aceclofenac]], [[Acemetacin]], [[Alendronate]], [[Aspirin]], [[Azapropazone]], [[Benoxaprofen]], [[Bisphosphonates]], [[Celecoxib]], [[Clopidogrel]], [[Diclofenac]], [[Diflunisal]], [[Ethanol]], [[Etodolac]], [[Etoricoxib]], [[Fenbufen]], [[Fenoprofen]], [[Flurbiprofen]], [[Glucocorticoids]], [[Ibuprofen]], [[Indomethacin]], [[Ketoprofen]], [[Laxative abuse]], [[Mefenamic acid]], [[Meloxicam]], [[Nabumetone]], [[Naproxen]], [[Non steroidal anti-inflammatory drugs]], [[Para-amino salicylic acid]], [[Phenylbutazone]], [[Piroxicam]], [[Prednisolone]], [[Rofecoxib]], [[Sulindac]], [[Tacrolimus]], [[Tenoxicam]], [[Tiaprofenic acid]], [[Tolazoline]], [[Trimetrexate]] | | bgcolor="Beige" | [[Aceclofenac]], [[Acemetacin]], [[Alendronate]], [[Aspirin]], [[Azapropazone]], [[Benoxaprofen]], [[Bisphosphonates]], [[Celecoxib]], [[Clopidogrel]], [[Diclofenac]], [[Diflunisal]], [[Ethanol]], [[Etodolac]], [[Etoricoxib]], [[Fenbufen]], [[Fenoprofen]], [[Flurbiprofen]], [[Glucocorticoids]], [[Ibuprofen]], [[Indomethacin]], [[Ketoprofen]], [[Laxative abuse]], [[Mefenamic acid]], [[Meloxicam]], [[Nabumetone]], [[Naproxen]], [[Non steroidal anti-inflammatory drugs]], [[Para-amino salicylic acid]], [[Phenylbutazone]], [[Piroxicam]], [[Prednisolone]], [[Rofecoxib]], [[Sulindac]], [[Tacrolimus]], [[Tenoxicam]], [[Tiaprofenic acid]], [[Tolazoline]], [[Trimetrexate]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Psychiatric''' | | '''Psychiatric''' | ||
|bgcolor="Beige"| [[Curling ulcers]] | | bgcolor="Beige" | [[Curling ulcers]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Pulmonary''' | | '''Pulmonary''' | ||
|bgcolor="Beige"| | | bgcolor="Beige" | Sarcoidosis | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Renal / Electrolyte''' | | '''Renal / Electrolyte''' | ||
|bgcolor="Beige"| | | bgcolor="Beige" | Hypercalcemia | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Rheum / Immune / Allergy''' | | '''Rheum / Immune / Allergy''' | ||
|bgcolor="Beige"| | | bgcolor="Beige" | [[Fibromyalgia]]<ref name="pmid28384332" /> | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Sexual''' | | '''Sexual''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Trauma''' | | '''Trauma''' | ||
|bgcolor="Beige"| [[Burns]] | | bgcolor="Beige" | [[Burns]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Urologic''' | | '''Urologic''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Dental''' | | '''Dental''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Miscellaneous''' | | '''Miscellaneous''' | ||
|bgcolor="Beige"| [[Alcohol]], [[Caffeine]], [[Smoking]] | | bgcolor="Beige" | [[Alcohol]], [[Caffeine]], [[Smoking]] | ||
|- | |- | ||
|} | |} | ||
Revision as of 18:20, 16 November 2017
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Peptic ulcer Microchapters |
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Diagnosis |
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Treatment |
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Surgery |
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Case Studies |
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2017 ACG Guidelines for Peptic Ulcer Disease |
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Guidelines for the Indications to Test for, and to Treat, H. pylori Infection |
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Guidlines for factors that predict the successful eradication when treating H. pylori infection |
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Guidelines to document H. pylori antimicrobial resistance in the North America |
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Guidelines for evaluation and testing of H. pylori antibiotic resistance |
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Guidelines for when to test for treatment success after H. pylori eradication therapy |
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Guidelines for penicillin allergy in patients with H. pylori infection |
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Peptic ulcer causes On the Web |
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American Roentgen Ray Society Images of Peptic ulcer causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Common causes of peptic ulcer disease include Helicobacter pylori infection and NSAID use. Less common causes of peptic ulcer disease include Crohn's disease, Zollinger-Ellison syndrome, Cushing and Curling ulcers, Carcinoid tumors, and carcinoid syndrome.
Causes
Common Causes
Less common causes of peptic ulcer disease
- Hormonal or mediator-induced including secondary acid hypersecretory states
- Antral g - cell hyperfunction
- Post-surgical -Antral exclusion and post gastric bypass surgery
- Tumors-cancers and lymphoma
- Cameron ulcer (gastric ulcer where a hiatus hernia passes through the diaphragmatic hiatus)
- True idiopathic ulcer.
Rare causes of peptic ulcer disease [1]
- Crohn’s disease of the stomach or duodenum
- Eosinophilic gastroduodenitis
- Systemic mastocytosis
- Radiation damage
- Viral infections (eg cytomegalovirus or herpes simplex infection, in particular in immunocompromised patients)
- Colonisation of stomach with H heilmanii
- Severe systemic disease
Genetic causes -[3]
- Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.
Causes by Organ System
Causes in Alphabetical Order
Causes by organ sys
- For an example of the causes by organ system table in a causes microchapter, click here.
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | Rosacea,Chronic idiopathic urticaria ,Psoriasis vulgaris ,Behcet's disease ,Alopecia areata,Sweet's syndrome [4] |
| Drug Side Effect | serotonin reuptake -NSAIDs,Clopidogrel,spironolactone,sirolimus,bisphosphonates (when combined with NSAIDs),mycophenolate mofetil,spironolactone ,chemotherapy (hepatic infusion of 5 - fluorouracil ,selective serotonin reuptake inhibitor |
| Ear Nose Throat | No underlying causes |
| Endocrine | Diabetes mellitus |
| Environmental | smoking, excess alcohol consumption, caffeine ,more common in patients with Diabetes Mellitus ,hypertension ,metabolic syndrome[6] |
| Gastroenterologic | Crohn’s disease of the stomach or duodenum, Eosinophilic gastroduodenitis |
| Genetic | Zollinger -Ellison syndrome associated with MEN TYPE 1 syndrome caused by mutation in MEN gene present on chromosome 11q 13 |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | Helicobacter pylori (60% gastric and 50-75% duodenal ulcers ), Herpes simplex virus type 1, Cytomegalovirus, Helicobacter heilmannii, Tuberculosis, syphilis, and mucormycosis |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Non-beta cell tumor ,carcinoid syndrome , gastrinomas |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | severe stress, depressed mood, suicidal ideation and psychological counseling [6] |
| Pulmonary | COPD,Sarcoidosis |
| Renal/Electrolyte | Hypercalcemia |
| Rheumatology/Immunology/Allergy | Fibromyalgia[5] |
| Sexual | No underlying causes |
| Trauma | Cushing ulcers |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
References
- ↑ 1.0 1.1 Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
- ↑ Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
- ↑ Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
- ↑ 4.0 4.1 Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E; et al. (2014). "Helicobacter pylori infection and skin disorders". Hong Kong Med J. 20 (4): 317–24. doi:10.12809/hkmj134174. PMID 25045884.
- ↑ 5.0 5.1 Wang KA, Wang JC, Lin CL, Tseng CH (2017) Association between fibromyalgia syndrome and peptic ulcer disease development. PLoS One 12 (4):e0175370. DOI:10.1371/journal.pone.0175370 PMID: 28384332
- ↑ 6.0 6.1 Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW; et al. (2017). "The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article". Medicine (Baltimore). 96 (34): e7828. doi:10.1097/MD.0000000000007828. PMC 5572011. PMID 28834889.