|
|
| Line 42: |
Line 42: |
| *[[Diarrhea|Diarrhoea]] | | *[[Diarrhea|Diarrhoea]] |
| <br /> | | <br /> |
| *'''Functional Pancreatic Neuroendocrine Tumors and their Characteristics are mentioned in the following table:'''<ref name="pmid25207767">{{cite journal| author=Ryan DP, Hong TS, Bardeesy N| title=Pancreatic adenocarcinoma. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 11 | pages= 1039-49 | pmid=25207767 | doi=10.1056/NEJMra1404198 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25207767 }} </ref>
| |
|
| |
| {|
| |
| ! colspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Functional Pancreatic Neuroendocrine Tumors and their Characteristics'''
| |
| |+
| |
| | colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Tumor type and syndrome'''
| |
| | colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Location in pancreas'''
| |
| | colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Signs and symptoms'''
| |
| | colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Circulating biomarkers'''
| |
| |-
| |
| | style="background:#DCDCDC; + " | '''Insulinoma (Whipple’s triad)'''
| |
| | style="background:#F5F5F5; + " |
| |
| *Head, body, tail (evenly distributed)
| |
| | style="background:#F5F5F5; + " |
| |
| *[[Hypoglycemia]], [[dizziness]], [[Perspiration|sweating]], [[tachycardia]], [[Tremor|tremulousness]], [[confusion]], [[seizure]]
| |
| | style="background:#F5F5F5; + " |
| |
| *CgA and CgB, [[insulin]] inappropriate for [[Blood sugar|blood glucose]] level, [[proinsulin]], [[C-peptide]]
| |
| |-
| |
| | style="background:#DCDCDC; + " | '''Gastrinoma (Zollinger–Ellison)'''
| |
| | style="background:#F5F5F5; + " |
| |
| *[[Gastrinoma (patient information)|Gastrinoma]] triangle: Often extrapancreatic ([[Duodenum|duodenal]]); can be found anywhere in [[gland]]
| |
| | style="background:#F5F5F5; + " |
| |
| *[[Gastric acid]] hypersecretion, [[peptic ulcer]], [[diarrhea]], [[esophagitis]], [[Abdominal pain|epigastric pain]]
| |
| | style="background:#F5F5F5; + " |
| |
| *CgA, [[gastrin]], [[Pancreatic polypeptide|PP]] (35%)
| |
| |-
| |
| | style="background:#DCDCDC; + " | '''VIPoma (Verner– Morrison syndrome, WDHA)'''
| |
| | style="background:#F5F5F5; + " |
| |
| *Distal [[pancreas]] (body and tail) Often spread outside [[pancreas]]
| |
| | style="background:#F5F5F5; + " |
| |
| *[[Diarrhea|Watery diarrhea]], [[hypokalemia]], [[achlorhydria]] (or [[acidosis]])
| |
| | style="background:#F5F5F5; + " |
| |
| *CgA, [[Vasoactive intestinal peptide|VIP]]
| |
| |-
| |
| | style="background:#DCDCDC; + " | '''Glucagonoma'''
| |
| | style="background:#F5F5F5; + " |
| |
| *Body and tail of [[pancreas]]: Often large and spread outside [[pancreas]]
| |
| | style="background:#F5F5F5; + " |
| |
| *[[Diabetes]] ([[hyperglycemia]]), [[necrolytic migratory erythema]], [[stomatitis]], [[glossitis]], [[angular cheilitis]]
| |
| | style="background:#F5F5F5; + " |
| |
| *CgA, [[glucagon]], glycentin
| |
| |-
| |
| | style="background:#DCDCDC; + " | '''Somatostatinoma'''
| |
| | style="background:#F5F5F5; + " |
| |
| *Pancreatoduodenal groove, [[Ampulla of Vater|ampullary]], periampullary
| |
| | style="background:#F5F5F5; + " |
| |
| *[[Gallstone disease|Gallstones]], [[diabetes]] ([[hyperglycemia]]), [[steatorrhea]]
| |
| | style="background:#F5F5F5; + " |
| |
| *CgA, [[somatostatin]]
| |
| |-
| |
| | style="background:#DCDCDC; + " | '''Ppoma'''
| |
| | style="background:#F5F5F5; + " |
| |
| *Head of [[pancreas]]
| |
| | style="background:#F5F5F5; + " |
| |
| *None
| |
| | style="background:#F5F5F5; + " |
| |
| *CgA, [[Pancreatic polypeptide|PP]]
| |
| |-
| |
| |}
| |
|
| |
|
| ==References== | | ==References== |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
A positive history of cigarette smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing pancreatic cancer. The most common symptoms of pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight loss, dark urine and light-colored or greasy stools.
History and Symptoms
A positive history of cigarette smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing pancreatic cancer. The most common symptoms of pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight loss, dark urine and light-colored or greasy stools.
History
Patients with pancreatic cancer may have a positive history of:
Common Symptoms
Common symptoms of pancreatic cancer include:
Less Common Symptoms
Less common symptoms of pancreatic cancer include:
References
Template:WikiDoc Sources