Anxiety differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

Anxiety must be differentiated from other diseases that cause anxiety such as major depressive disorder, bipolar disorder, atypical psychosis, schizophrenia, other medical and neurologic conditions.

Differential diagnosis

Anxiety must be differentiated from below causes:

psychiatric	Cardinal features
Major depressive disorder	DSM major depressive disorder (MDD) diagnostic criteria require the occurrence of one or more major depressive episodes. Symptoms of a major depressive episode include the following: Depressed mood Anhedonia (diminished loss of interest or pleasure in almost all activities) Significant weight or appetite disturbance Sleep disturbance Psychomotor agitation or retardation (a speeding or slowing of muscle movement) Loss of energy or fatigue Feelings of worthlessness Diminished ability to think, concentrate and make decisions Recurrent thoughts of death, dying or suicide Longstanding interpersonal rejection ideation (ie. others would be better off without me); specific suicide plan; suicide attempt. The DSM states either a depressed mood or anhedonia must be present. In addition to the above DSM criteria for a major depressive episode, the episode must: Be at least two weeks long Cause significant distress or severely impact social, occupational or other important life areas Not be precipitated by drug use Not meet the criteria for another mental disorder like schizophrenia or bipolar disorder Not be better explained by bereavement (such as the loss experienced after a death)
Bipolar I disorder	[[BipolarI disorder- A person affected bybipolarI disorder has had atleast one manic episode in his/her life, and also suffer from episodes of depression, there ia an alternating pattern of mania and depresssion. manic episode is characterized by: A period od abnormally elevated or irritable mood and increased goal directed activity,lasting atleats one week and present most of the day, nearly every day. 8 During the period of mood disturbance and increased energy /activity, three (or more) of the following symptoms ( four if the mood is only irritable) are present to a significant degree and represent a noticeable change from usual behavior: 1. Grandiosity 2.Decreased need for sleep 3. More talkative than usual or pressure to keep talking 4. Flight of ideas 5.Distractability 6Increase in goal directed activity 7excessive involvement in activities that have dire consequnces(e.g. engaging in exceesive buying, sexual activity. The mood disturbance is sufficiently severe to cause marked impairment in social or occupational functioning the episode is not attributable to the physiological effects of a substance depressive episodes of bipolar diosrder are similer to clinical depression.]]
Atypical psychosis	[[The term atypical psychosis has not been included in DSM-V, but was liste in DSM-III-R under the heading psychosis Not otherwise specified( examples include: postpartum psychosis, psychosis with unusual features, psychosis with confusing clinical features that make a more definite diagnosis impossible]]
Schizophrenia	Hypoglycemia
Substance abuse	Hyperthyroidism
Cognitive disorders	Carcinoid