Glucagonoma laboratory tests: Difference between revisions
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2], Mohammed Abdelwahed M.D[3]
Overview
Laboratory findings consistent with the diagnosis of glucagonoma include a serum glucagon concentration of 1000 pg/ml or greater.
Laboratory Findings
The laboratory findings associated with glucagonoma are:[1][2][1][3][4]
Serum glucagon
- Increased plasma glucagon levels >500 pg/mL (Normal glucagon level is less than 50 pg/mL).
- Concentrations above 1000 pg/mL are diagnostic of glucagonoma.
- Some conditions can increase glucagon level to a level less than 500 pg/mL such as fasting and hypoglycemia.
- Some symptomatic glucagonomas are associated with normal glucagon serum level. So, a serum glucagon concentration below 500 pg/mL does not exclude a glucagonoma.[4]
Other laboratory findings
- Blood tests may also reveal low concentrations of amino acids, zinc, and essential fatty acids.
- A complete blood count (CBC) to diagnose anemia.
References
- ↑ 1.0 1.1 Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS (2004). "Clinical experience in diagnosis and treatment of glucagonoma syndrome". Hepatobiliary Pancreat Dis Int. 3 (3): 473–5. PMID 15313692.
- ↑ Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. Accessed on October 15,2015
- ↑
- ↑ 4.0 4.1 Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET; et al. (2007). "Endocrine [[pancreatic tumors]] with [[glucagon]] hypersecretion: a retrospective study of 23 cases during 20 years". Med Oncol. 24 (3): 330–7. PMID 17873310. URL–wikilink conflict (help)