Hodgkin's lymphoma differential diagnosis: Difference between revisions

Differential Diagnosis
	DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Differential Diagnosis
	DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

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Revision as of 02:04, 27 November 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hodgkin's lymphoma must be differentiated from sarcoidosis, lymphocytic lymphoma, miliary tuberculosis, infectious mononucleosis, thoracic aortic aneurysm, substernal goiter, thymoma, actinomycosis, chronic lymphocytic leukemia, superior vena cava syndrome, unicentric castleman disease, adult still disease, small cell lung carcinoma, and malignant histiocytosis.

Differential Diagnosis

The following conditions must be considered in the differential diagnosis of Hodgkin's lymphoma: DDx ^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Sarcoidosis DDx
Lymphocytic lymphoma DDx
Miliary tuberculosis DDx
Infectious mononucleosis DDx
Thoracic aortic aneurysm DDx
Substernal goiter DDx
Thymoma DDx
Actinomycosis DDx
Chronic lymphocytic leukemia DDx
Superior vena cava syndrome DDx
Unicentric Castleman disease DDx
Adult Still disease DDx
Small cell lung carcinoma DDx
Malignant histiocytosis DDx

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Mahshid Mir, M.D. [3]

Template:WikiDoc Sources

Clinical manifestations

Mental nerve neuropathy
Alcohol intolerance
Exfoliative dermatitis
Epitrochlear lymph node enlargement
Inguinal lymph node enlargement
Hepatomegaly
Liver mass
Superior vena cava obstruction
Inferior vena cava obstruction
Femoral lymph node enlargement
Popliteal lymph node enlargement
Pemberton sign positive
Pel-Ebstein fever
Chylous ascites
Axillary lymph node enlargement
Erythema multiforme
Erythema nodosum
Hepatosplenomegaly
Mesenteric lymph node enlargement
Paraplegia
Pruritus
Spinal cord compression
Spleen enlargement
Urinary tract obstruction
Generalized diffuse lymph node enlargement
Airway compression or obstruction
Cryptococcosis
Bone pain
Cervical lymph node enlargement
Recurrent fever
Recurrent infection
Fixed lymph node
Neck mass
Night sweats
Malaise
Supraclavicular lymph node enlargement
Sweating increase
Fever unknown origin
Remittent fever
Painless lymphadenopathy
Regional lymph node enlargement

Laboratory abnormalities

Nucleated red cells
Hypogammaglobulinemia
Pancytopenia
Lymphocytes decreased
Granulomas on biopsy

Radiographic features

Retroperitoneal lymph node enlargement
Biliary tract dilatation on abdominal ultrasound
Bone lesion
Mediastinal mass,adenopathy, or widening on chest xray
Middle mediastinal mass on chest xray
Mediastinal lymph node enlargement
Anterior mediastinal mass on chest radiograph
Increased uptake on abdomen gallium scan
Ivory vertebra
Increased uptake on mediastinum gallium scan

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4] Mahshid Mir, M.D. [5]

Template:WikiDoc Sources

Clinical manifestations

Corneal deposit
Corneal opacity
Parotid gland swelling
Polyneuropathy
Cranial nerve paralysis
Airway compression or obstruction
Retinal granuloma
Erythema nodosum
Uveitis
Ankle pain
Facial paralysis
Salivary gland swelling
Massive splenomegaly
Cryptococcosis
Generalized rash, papules (elevated, <0.5cm)
Iridocyclitis
Iritis
Dry cough
Night sweats
Spleen enlargement
Bilateral uveitis
Generalized diffuse lymph node enlargement
Polyarthritis

Laboratory abnormalities

Hypercalcemia
Increased lymphocytes in pleural effusion
Decreased Lymphocytes
Hypercalciuria
Mild-moderate elevation of alkaline phosphatase
PFT's: restrictive defect
PFT's: diffusion capacity decreased
Elevated serum angiotensin-converting enzyme
Increased vitamin D, 1,25-dihydroxy

Radiographic features

Heart conduction abnormality on electrocardiographic
Atrioventricular block
Retroperitoneal lymph node enlargement
Lung cyst on chest radiography
Interstitial infiltrate ( incl. reticulonodular )on chest radiography
Increased mediastinal uptake on gallium scan
Increased lung uptake on gallium scan
Mediastinal lymph node enlargement
Bone marrow granulomas
Mediastinal mass, adenopathy, or widening on chest radiography
Granulomas on biopsy
Hilar lymph node enlargement on chest radiography

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [6] Mahshid Mir, M.D. [7]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Mental nerve neuropathy
Exfoliative dermatitis
Lower extremity paralysis
Gout
Esophageal candidiasis
Abdominal mass
Biliary tract obstruction
Breast mass
Epitrochlear lymph node enlargement
Erythema multiforme
Erythema nodosum
Esophageal obstruction
Facial edema
Gastric obstruction
Thyroid nodule
Hepatosplenomegaly
Intestinal obstruction
Intussusception
Liver mass
Mesenteric lymph node enlargement
Mucous membrane bleeding
Night sweats
Paraplegia
Pruritus
Anergy
Spinal cord compression
Stool clay color
Stool color yellow
Superior vena cava obstruction
Supraclavicular lymph node enlargement
Testicular mass
Urinary tract obstruction
Inferior vena cava obstruction
Generalized diffuse lymph node enlargement
Massive splenomegaly
Femoral lymph node enlargement
Popliteal lymph node enlargement
Airway compression or obstruction
Cryptococcosis
Recurrent infection
Fixed lymph node
Neck mass
Spleen enlargement
Fever unknown origin
Regional lymph node enlargement
Painless lymphadenopathy
Cancer
Lymphoma
Non-Hodgkin lymphoma

Laboratory abnormalities

Extreme hypercalcemia (>14 mg/dl)
Prolonged bleeding time
Markedly increased ESR
Hypogammaglobulinemia
Pancytopenia
Lymphocytes decreased
Pleural effusion (Exudate)
Bone marrow plasma cells increased
Lymphocytes increased in pleural effusion
Pleural effusion (Chylous)
Malignant ascites
Cryoglobulinemia
Vitamin D, 1,25-dihydroxy increased

Radiographic features

Bladder mass or abnormal shape on IVP
Bone destruction
Kidney mass
Mediastinal lymph node enlargement
Bone lesion
Retroperitoneal lymph node enlargement
Mediastinal mass, adenopathy, or widening on chest radiography
Anterior mediastinal mass on chest radiography
Biliary tract dilatation on abdominal ultrasound
Increased mediastinal uptake on gallium scan
Increased abdominal uptake on gallium scan

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [8] Mahshid Mir, M.D. [9]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Prison inmate
Retinal granuloma
Erythema nodosum
Travel history (Haiti)
Immunosuppressive therapy
Severe weight loss
Corticosteroid use
Pleuritic chest pain
Progressive dyspnea
Fever unknown origin
Retinitis
Tuberculosis exposure

Laboratory abnormalities

Pancytopenia
PPD positive
Nucleated red cells
Bone marrow granulomas
AFB smear positive
Granulomas on biopsy

Radiographic features

Increased abdominal uptake on gallium scan
Multiple hypodense liver lesions on abdominal CT
Multiple non-calcified pulmonary nodules on chest radiography

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [10] Mahshid Mir, M.D. [11]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Optic neuritis
Epitrochlear lymph node enlargement
Periorbital edema
Pharyngeal petechia
Spleen enlargement
Spleen palpable
Tonsillitis
Left upper quadrant abdominal tenderness
Axillary lymph node enlargement
Inguinal lymph node enlargement
Pesenteric lymph node enlargement
Pharyngeal exudate
Pharyngeal erythema
Spleen tenderness
Tonsillar exudate
Generalized diffuse lymph node enlargement
Cervical lymph node enlargement
Pharyngeal swelling
Sore throat

Laboratory abnormalities

Marked elevationSGPT (ALT)
SGPT (ALT) elevated
Lymphocytes increased
Atypical lymphocytes increased
Heterophile antibody positive
Monocytes increased
Epstein-Barr virus titre positive

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [12] Mahshid Mir, M.D. [13]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Cocaine use
Turner syndrome
Pemberton sign positive
Marfan syndrome
Aortic valve regurgitation
Superior vena cava obstruction
Ascending aortic dilation

Radiographic features

Anterior mediastinal mass on chest radiography
Middle mediastinal mass on chest radiography
Posterior mediastinal mass on chest radiography
Aorta prominent or enlarged on chest radiography

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [14] Mahshid Mir, M.D. [15]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Upper extremity edema
Chest mass
Neck mass
Thyroid enlargement
Tracheal compression
Pemberton sign positive

Laboratory abnormalities

TSH elevated

Radiographic features

Mediastinal mass, adenopathy, or widening on chest radiograph

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [16] Mahshid Mir, M.D. [17]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Bulbar palsy
Facial candida infection
Facial cyanosis
Jugular venous distention
Mouth candida infection
Superior vena cava obstruction
Diplopia
Pemberton sign positive

Laboratory abnormalities

Pancytopenia
Antistriational antibodies

Radiographic features

Mediastinal mass, adenopathy, or widening on chest radiograph
Anterior mediastinal mass on chest radiograph

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [18] Mahshid Mir, M.D. [19]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Tongue mass
Trismus
Pericardial constriction
Pharyngeal swelling
Pharyngeal tenderness
Abdominal fistula
Bronchial fistula
Empyema
Lung abscess
Right lower quadrant abdominal mass
Chest wall suppuration
Gingival fistula
Chest wall fistula
Gingival swelling
Gingival tenderness
Jaw induration
Mandibular swelling

Laboratory abnormalities

Branching Gram-positive bacilli on Gram stain
Sulfur granule

Radiographic features

Mediastinal mass, adenopathy, or widening on chest radiography
Intracardiac mass on echocardiogram
Hepatic cyst(s)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [20] Mahshid Mir, M.D. [21]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Skin infiltration
Sternal tenderness
Lymph node firmness

Laboratory abnormalities

Hemolysis
Prolonged bleeding time
Monoclonal gammopathy
Cryoglobulinemia
Marked increase of leukocytes
Clonal B-lymphocytes on flow cytometry
Lymphocytes increased

Radiographic features

Mediastinal mass, adenopathy, or widening on chest radiography

The following findings (if present) would make this disease less likely:

Left shift
Metamyelocytes increased

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [22] Mahshid Mir, M.D. [23]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Stridor
Facial erythema
Forehead vein distention
Lymphoma
Tracheal displacement
Chest vein distention
Facial cyanosis
Collateral circulation increase
Conjunctival edema
Conjunctival vein distention
Upper extremity edema
Upper extremity erythema
Head edema
Jugular venous distention with inspiration
Lung tumor
Extremity cyanosis
Upper extremity vein distention
Facial edema
Neck edema
Jugular venous distention
Lung cancer
Upper extremity cyanosis
Facial vein distention
Superior vena cava obstruction

Radiographic features

Mediastinal lymph node enlargement
Non-calcified pulmonary nodule (< 4 cm) on chest radiography
Mediastinal mass, adenopathy, or widening on chest radiography

The following findings (if present) would exclude this disease:

hepatojugular reflux

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [24] Mahshid Mir, M.D. [25]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Radiographic features

Mediastinal mass, adenopathy, or widening on chest radiography

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [26] Mahshid Mir, M.D. [27]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Ankylosis
Hepatosplenomegaly
Severe weight loss
Recurrent fever
Night sweats
Wrist pain
Generalized diffuse lymph node enlargement
Fever unknown origin
Remittent fever
High grade fever
Polyarticular
Evanescent rash

Laboratory abnormalities

Leukocytes, marked increase
ESR markedly increased
Serum ferritin greatly increased

The following findings (if present) would make this disease less likely:

monoarticular

The following findings (if present) would exclude this disease:

asymptomatic

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [28] Mahshid Mir, M.D. [29]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Acanthosis nigricans
Axillary lymph node enlargement
Axillary lymph node pain
Dysphagia
Esophageal obstruction
Heart tamponade
Pericardial effusion
Lower rib tenderness
Tracheal displacement
Hoarseness
Digital clubbing
Airway compression or obstruction
Pemberton sign positive
Velvet palms
Horner syndrome
Superior vena cava obstruction
Bone pain
Spinal cord compression
Supraclavicular lymph node enlargement
Intracranial metastatic tumor
Acute symmetrical peripheral neuropathy
Hemoptysis
Right supraclavicular lymph node enlargement
Tobacco smoking

Laboratory abnormalities

Bone destruction
Unilateral diaphragm elevation on chest radiography
Non-calcified pulmonary nodule (< 4 cm) on chest radiography
Mediastinal mass, adenopathy, or widening on chest radiography
Pleural effusion
Pleural effusion (bloody)
Non-calcified pulmonary mass (>= 4 cm)on chest radiography
Hyponatremia
Bone marrow tumor cells
Serum calcitonin increased
Hilar lymph node enlargement on chest radiography

Radiographic features

Normal on chest radiography
Normal on chest CT (contrast enhanced)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [30] Mahshid Mir, M.D. [31]

Differential Diagnosis
DDx Alphabetic Order
A	B
C	D
E	F
G	H
I	J
K	L
M	N
O	P
Q	R
S	T
U	V
W	X
Y	Z

Template:WikiDoc Sources

Clinical manifestations

Tendon xanthoma
Xanthoma
Tuberous xanthoma
Planar xanthoma
Palmar planar xanthoma
Hepatosplenomegaly
Spleen enlargement
Panniculitis
Generalized diffuse lymph node enlargement

Laboratory abnormalities

ESR markedly increased
Serum ferritin greatly increased
ESR mildly or moderately increased
C-reactive protein elevated

References

↑ Ferri, Fred (2011). Ferri's differential diagnosis: a practical guide to the differential diagnosis of symptoms, signs, and clinical disorders. Philadelphia, PA: Elsevier/Mosby. ISBN 978-0323076999.
↑ Siegenthaler, Walter (2007). Differential diagnosis in internal medicine: from symptom to diagnosis. Stuttgart New York: Thieme. ISBN 978-1588905512.
↑ Mesko, Dusan (2002). Differential diagnosis by laboratory medicine: a quick reference for physicians. Berlin New York: Springer-Verlag. ISBN 978-3540430575.
↑ Reeder and Felson's gamuts in radiology: comprehensive lists of roentgen differential diagnosis. Place of publication not identified: Springer. 2014. ISBN 978-1475781229.
↑ Burgener, Francis (2008). Differential diagnosis in conventional radiology. Stuttgart New York: Thieme. ISBN 978-1588902757.
↑ Gattuso, Paolo (2015). Differential diagnosis in surgical pathology. Philadelphia, PA: Saunders/Elsevier. ISBN 978-1455770137.
↑ "DXplain".

[1] Ferri, Fred (2011). Ferri's differential diagnosis: a practical guide to the differential diagnosis of symptoms, signs, and clinical disorders. Philadelphia, PA: Elsevier/Mosby. ISBN 978-0323076999.

[2] Siegenthaler, Walter (2007). Differential diagnosis in internal medicine: from symptom to diagnosis. Stuttgart New York: Thieme. ISBN 978-1588905512.

[3] Mesko, Dusan (2002). Differential diagnosis by laboratory medicine: a quick reference for physicians. Berlin New York: Springer-Verlag. ISBN 978-3540430575.

[4] Reeder and Felson's gamuts in radiology: comprehensive lists of roentgen differential diagnosis. Place of publication not identified: Springer. 2014. ISBN 978-1475781229.

[5] Burgener, Francis (2008). Differential diagnosis in conventional radiology. Stuttgart New York: Thieme. ISBN 978-1588902757.

[6] Gattuso, Paolo (2015). Differential diagnosis in surgical pathology. Philadelphia, PA: Saunders/Elsevier. ISBN 978-1455770137.

[7] "DXplain".

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 [[Category:primary care]]
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Hematology]]
+[[Category:Immunology]]

Hodgkin's lymphoma differential diagnosis: Difference between revisions

Revision as of 02:04, 27 November 2017

Overview

Differential Diagnosis

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Laboratory abnormalities

Clinical manifestations

Radiographic features

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Radiographic features

Radiographic features

Clinical manifestations

Laboratory abnormalities

Clinical manifestations

Laboratory abnormalities

Radiographic features

Clinical manifestations

Laboratory abnormalities

References

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