Mast cell tumor differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Mast cell tumor must be differentiated from other diseases that cause flushing,such as: phaeochromocytoma and carcinoid syndrome. Mast cell tumor must be differentiated from other diseases that cause elevated serum tryptase levels and cytopenia, such as: myelodysplastic syndrome, primary myelofibrosis, essential thrombocythemia, and chronic eosinophilic leukemia.

Differential Diagnosis

Mast cell tumor must be differentiated from other diseases that cause flushing:

• Phaeochromocytoma
• Carcinoid syndrome

Mast cell tumor must be differentiated from other diseases that cause abdominal pain and discomfort:

• Irritable bowel syndrome
• Inflammatory bowel disease
• Zollinger-Ellison syndrome

Mast cell tumor must be differentiated from other diseases that cause elevated serum tryptase levels and cytopenia, such as:

• Myelodysplastic syndrome
• Primary myelofibrosis
• Essential thrombocythemia
• Chronic eosinophilic leukemia
• Chronic myeloid leukemia
• Myelomastocytic leukemia
• Malignant lymphoma