Ovarian germ cell tumor laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

The laboratory findings associated with ovarian germ cell tumor are serum lactate dehydrogenase (LDH), human chorionic gonadotropin (HCG), CA-125, and alpha-fetoprotein (AFP).

Ovarian germ cell tumor Laboratory Findings

The tumor marker associated with ovarian germ cell tumor subtypes are as follows:

Ovarian germ cell tumor subtype	Tumor markers expressed
Dysgerminoma	Serum lactate dehydrogenase (LDH) Human chorionic gonadotropin (hCG)
Endodermal sinus tumor or yolk sac tumors	Alpha-fetoprotein (AFP)
Embryonal Carcinoma	hCG, AFP
Teratoma	Rarely produce tumor markers: AFP and CA-125
Choriocarcinoma	hCG