Seminoma pathophysiology: Difference between revisions
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Revision as of 16:37, 27 November 2017
Seminoma Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Seminoma pathophysiology On the Web |
American Roentgen Ray Society Images of Seminoma pathophysiology |
Risk calculators and risk factors for Seminoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1] On microscopic pathology, seminoma is characterized by the cells with fried egg appearance with clear cytoplasm and central nucleus with prominent nucleolus, with interspersed lymphocytes and syncytiotrophoblasts.[2] Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0). Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2] Seminoma is demonstrated by positivity to tumor markers, such as OCT4, CD117, D2-40, and CD117.[3]
Gross Pathology
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]
Gallery
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Gross specimen of testicle demonstrating a solid, white/tan mass.[2]
Microscopic Pathology
- On microscopic pathology, seminoma is characterized by:[2]
- Cells with fried egg appearance - key feature
- Clear cytoplasm
- Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.
- Lymphocytes - interspersed (common)
- Syncytiotrophoblasts, present in 10-20% of seminoma
- Large, irregular, vesicular nuclei
- Eosinophilic vacuolated cytoplasm (contains hCG)
- Florid granulomatous reaction
- Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0).[2]
- Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2]
Gallery
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Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]
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Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]
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Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]
Immunohistochemistry
Seminoma is demonstrated by positivity to tumor markers, such as:[3]
References
- ↑ 1.0 1.1 Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016
- ↑ 3.0 3.1 IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016