Stomach cancer causes: Difference between revisions
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{{Stomach cancer}} | {{Stomach cancer}} | ||
== Overview == | |||
== Stomach cancer causes == | |||
* Causes of stomach cancer depends on type of cancer. | |||
* Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria. | |||
* ''[[Ras oncogene|K-ras]]'' [[Mutations|mutations oncogenes]] are found in [[Invasive (medical)|invasive]] [[Cancer|cancers]] and intestinal [[metaplasia]]. | |||
* [[Hepatocyte growth factor]] [[Receptor (biochemistry)|receptor]] c''-met'' [[oncogene]] is found in intestinal-type gastric cancers. | |||
* Almost 50% of gastric cancers have alterations in genes ''[[TP53 (gene)|TP53]],'' ''[[TP73L|TP73]]'', ''[[APC]]'', TFF, ''[[DCC1|DCC]]'', LOH, and ''[[FHIT]].'' | |||
* Inactivation of [[P53 (protein)|p53]] in gastric [[epithelial cells]] reduce their ability to undergo [[apoptosis]]. | |||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 16:28, 4 December 2017
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Overview
Stomach cancer causes
- Causes of stomach cancer depends on type of cancer.
- Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria.
- K-ras mutations oncogenes are found in invasive cancers and intestinal metaplasia.
- Hepatocyte growth factor receptor c-met oncogene is found in intestinal-type gastric cancers.
- Almost 50% of gastric cancers have alterations in genes TP53, TP73, APC, TFF, DCC, LOH, and FHIT.
- Inactivation of p53 in gastric epithelial cells reduce their ability to undergo apoptosis.