Gastroesophageal reflux disease overview: Difference between revisions
No edit summary |
|||
| Line 41: | Line 41: | ||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
Laboratory findings consistent with diagnosis of GERD is the presence of acidic reflux in the esophagus through the ambulatory reflux monitoring. | |||
===X ray === | ===X ray === | ||
X ray imaging suggestive for associated problems with GERD include free acid reflux, esophagitis with scarring, strictures, and barrett's esophagus. | |||
=== CT scan === | === CT scan === | ||
| Line 52: | Line 54: | ||
=== Echocardiography or ultrasound === | === Echocardiography or ultrasound === | ||
There are no ultrasound findings associated with GERD. | There are no ultrasound findings associated with GERD. | ||
=== Other Imaging Studies === | |||
There are no other imaging findings associated with GERD. However, Endoscopy may be used in screening for the complications associated with chronic GERD like barrett's esophagus. | |||
===Other Diagnostic Studies=== | ===Other Diagnostic Studies=== | ||
There are no other diagnostic studies associated with GERD. | |||
==Treatment== | ==Treatment== | ||
Revision as of 16:21, 5 December 2017
|
Gastroesophageal reflux disease Microchapters |
|
Differentiating Gastroesophageal Reflux Disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Gastroesophageal reflux disease overview On the Web |
|
American Roentgen Ray Society Images of Gastroesophageal reflux disease overview |
|
Directions to Hospitals Treating Gastroesophageal reflux disease |
|
Risk calculators and risk factors for Gastroesophageal reflux disease overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Gastroesophageal reflux disease is defined as chronic symptoms due to damage to the esophageal mucosa as a result of abnormal reflux of acidic stomach contents into the esophagus[1]. This is commonly due to transient or permanent changes in the barrier between the esophagus and the stomach. This can be due to incompetence of the lower esophageal sphincter (LES), transient LES relaxation, impaired expulsion of gastric reflux from the esophagus, or a hiatal hernia. Chronic GERD is associated with an increased risk of Barrett's esophagus which is a premalignant condition of the esophageal mucosa which is in turn associated with an increased risk of adenocarcinoma of the esophagus.
Historical Perspective
GERD is believed to be first described and treated by the ancient Egyptians according to the papyrus which was discovered by Edwin Smith at Thebes. The esophagus itself was named by the ancient Greeks. Friedenwald and Feldman described the symptoms of GERD in 1925. Robbins and Jankelson used the radiological procedures to observe GERD in 1926.
Classification
GERD can be classified based on the endoscopic appearance of the esophageal mucosa and the clinical presentation of the disease.
Pathophysiology
Pathophysiology of GERD depends on several mechanisms that lead to the retrograde movement of the acidic content of the stomach to the esophagus. These mechanisms include transient lower esophageal sphincter relaxation, hypotensive lower esophageal sphincter, hiatal hernia, and prolonged esophageal acid clearance.
Causes
Common causes of GERD include obesity, autonomic neuropathy, systemic sclerosis, esophageal achalasia, and hiatus hernia. Other causes of GERD include hypochlorhydria, hypercalcemia, and Zollinger-Ellison syndrome.
Differentiating Gastroesophageal reflux disease overview from Other Diseases
GERD must be differentiated from other diseases like gastritis, peptic ulcer, crohn's disease, gastric adenocarinoma, and gastrinoma.
Epidemiology and Demographics
The prevalence of GERD in USA and Europe ranges from 10,000 to 20,000 per 100,000 people. The incidence of GERD increases with age especially above 40 years.
Risk Factors
Common risk factors of GERD include smoking, obesity, pregnancy, alcohol binge drinking, and medications like the anticholinergic drugs. Other risk factors include some kinds of food like spicy food and bad eating habits like eating large meals.
Screening
There is insufficient evidence to recommend routine screening for GERD.
Natural History, Complications, and Prognosis
If left untreated, 20% of patients with GERD may progress to develop esophageal stricture due to excessive acid in the lower esophagus. Complications of GERD include barrett's esophagus, erosive esophagitis, esophageal ulcer, and esophageal adenocarcinoma. Prognosis of GERD is good with the appropriate treatment.
Diagnosis
History and Symptoms
Common symptoms of GERD include heart burn, regurgitation, and dysphagia. A positive history of nausea, vomiting and regurgitation is suggestive of GERD. Other symptoms of GERD include chest pain, cough, and odynophagia.
Physical Examination
Patients with GERD usually appear ill due to the pain. Common physical examination include hoarseness of voice, laryngitis, otitis media, and lung wheezes.
Laboratory Findings
Laboratory findings consistent with diagnosis of GERD is the presence of acidic reflux in the esophagus through the ambulatory reflux monitoring.
X ray
X ray imaging suggestive for associated problems with GERD include free acid reflux, esophagitis with scarring, strictures, and barrett's esophagus.
CT scan
There are no CT findings associated with GERD.
MRI scan
There are no MRI findings associated with GERD.
Echocardiography or ultrasound
There are no ultrasound findings associated with GERD.
Other Imaging Studies
There are no other imaging findings associated with GERD. However, Endoscopy may be used in screening for the complications associated with chronic GERD like barrett's esophagus.
Other Diagnostic Studies
There are no other diagnostic studies associated with GERD.
Treatment
Medical Therapy
Surgery
Prevention
References
- ↑ DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. The Practice Parameters Committee of the American College of Gastroenterology. Am J Gastroenterol 1999;94:1434-42. PMID 10364004.