Alpha 1-antitrypsin deficiency overview: Difference between revisions
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==Screening== | ==Screening== | ||
According to the Spanish Society of Pneumology and Thoracic Surgery (SEPAR), All COPD patients should be screened for AATD at least once in their lifetime. | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
Revision as of 18:30, 5 December 2017
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Alpha 1-antitrypsin deficiency Microchapters |
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Differentiating Alpha 1-antitrypsin deficiency from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Alpha 1-antitrypsin deficiency overview On the Web |
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American Roentgen Ray Society Images of Alpha 1-antitrypsin deficiency overview |
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Directions to Hospitals Treating Alpha 1-antitrypsin deficiency |
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Risk calculators and risk factors for Alpha 1-antitrypsin deficiency overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Alpha 1-antitrypsin deficiency (A1AD or Alpha-1) is a genetic disorder caused by defective production of alpha 1-antitrypsin, deficient activity in the blood and lungs, and deposition of excessive amounts of abnormal A1AT protein in liver cells.[1] There are several forms and degrees of deficiency. Severe A1A deficiency causes emphysema and/or COPD in adult life in nearly all people with the condition, various liver diseases in a minority of children and adults, and occasionally more unusual problems.[2] It is treated by avoidance of damaging inhalants, by intravenous infusions of the A1AT protein, by transplantation of liver or lungs, and by a variety of other measures, but it usually produces some degree of disability and shortens life.
Historical Perspective
Classification
Pathophysiology
Differentiating Alpha 1-antitrypsin deficiency from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
According to the Spanish Society of Pneumology and Thoracic Surgery (SEPAR), All COPD patients should be screened for AATD at least once in their lifetime.