Eosinophilic esophagitis natural history: Difference between revisions

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Revision as of 16:29, 12 December 2017

The natural course of primary eosinophilic esophagitis is as follows:^[1]
In patients with EoE, symptoms persist over years raising suspicion that a chronic inflammatory process is an underlying event responsible for it.
The inflammatory activity is proportional to the density of the eosinophilic infiltration in the esophageal tissue.
Similar to asthma, EoE has chronic persistent eosinophilic inflammation and can eventually lead to irreversible structural changes of the esophagus which is called re-modeling of the esophagus.
The esophageal mucosa in patients with a longstanding EoE is characterized by a loss of elasticity.
On histologic examination of the subepithelial compartments of the esophagus show an increase in the fibrous tissue.
The endosonographic studies of the esophagus in patients with EoE shows following findings:
- Thickening of the mucosa
- Thickening of the submucosal, and muscularis propria layers
In patients with EoE, the chronic eosinophilic inflammation leads to an increased deposition of the fibrous connective tissue which in turn causes the remodeling of the esophagus hindering the esophageal transport.

@@ Line 5: / Line 5: @@
 ==Natural History==
+*The natural course of primary eosinophilic esophagitis is as follows:<ref name="pmid">{{cite journal |vauthors= |title= |journal= |volume= |issue= |pages= |year= |pmid= |doi= |url=}}</ref>
+*In patients with EoE, symptoms persist over years raising suspicion that a chronic inflammatory process is an underlying event responsible for it.
+*The inflammatory activity is proportional to the density of the eosinophilic infiltration in the esophageal tissue.
+*Similar to asthma, EoE has chronic persistent eosinophilic inflammation and can eventually lead to irreversible structural changes of the esophagus which is called re-modeling of the esophagus.
+*The esophageal mucosa in patients with a longstanding EoE is characterized by a loss of elasticity.
+*On histologic examination of the subepithelial compartments of the esophagus show an increase in the fibrous tissue.
+*The endosonographic studies of the esophagus in patients with EoE shows following findings:
+**Thickening of the mucosa
+**Thickening of the submucosal, and muscularis propria layers
+*In patients with EoE, the chronic eosinophilic inflammation leads to an increased deposition of the fibrous connective tissue which in turn causes the remodeling of the esophagus hindering the esophageal transport.
 ==Complications==