Lactose intolerance other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Lactose intolerance test may be helpful in the diagnosis of lactose intolerance. Findings suggestive of lactose intolerance include [[bloating]], [[diarrhea]] and [[abdominal pain]] and rising of blood [[glucose]] by less than 20 mg/dL after ingestion of lactose. Genetic test can also be used for diagnosis of primary lactase deficiency that is associated with CC [[genotype]] at -13.9 kb upstream of the lactase gene. | Lactose intolerance test may be helpful in the diagnosis of lactose intolerance. Findings suggestive of lactose intolerance include [[bloating]], [[diarrhea]] and [[abdominal pain]] and rising of blood [[glucose]] by less than 20 mg/dL after ingestion of [[lactose]]. Genetic test can also be used for diagnosis of primary lactase deficiency that is associated with CC [[genotype]] at -13.9 kb upstream of the [[lactase]] gene. | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
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**Lactose intolerance test: <ref name="pmid20686460">{{cite journal |vauthors=Law D, Conklin J, Pimentel M |title=Lactose intolerance and the role of the lactose breath test |journal=Am. J. Gastroenterol. |volume=105 |issue=8 |pages=1726–8 |year=2010 |pmid=20686460 |doi=10.1038/ajg.2010.146 |url=}}</ref> | **Lactose intolerance test: <ref name="pmid20686460">{{cite journal |vauthors=Law D, Conklin J, Pimentel M |title=Lactose intolerance and the role of the lactose breath test |journal=Am. J. Gastroenterol. |volume=105 |issue=8 |pages=1726–8 |year=2010 |pmid=20686460 |doi=10.1038/ajg.2010.146 |url=}}</ref> | ||
***50 gr of oral [[lactose]] in adults ( 2 g/kg in children) is administerd and blood [[glucose]] levels are checked at 0, 60, and 120 minutes after ingestion of [[glucose]]. | ***50 gr of oral [[lactose]] in adults ( 2 g/kg in children) is administerd and blood [[glucose]] levels are checked at 0, 60, and 120 minutes after ingestion of [[glucose]]. | ||
****Presentation of symptoms such as [[bloating]], [[diarrhea]] and [[abdominal pain]] and rising of blood [[glucose]] by less than 20 mg/dL (1.1 mmol/L) are diagnostic for lactose intolerance. | ****Presentation of [[Symptom|symptoms]] such as [[bloating]], [[diarrhea]] and [[abdominal pain]] and rising of blood [[glucose]] by less than 20 mg/dL (1.1 mmol/L) are diagnostic for lactose intolerance. | ||
****This test is used less than lactose breath hydrogen test because it needs repeated measurements of blood [[glucose]] level | ****This test is used less than lactose breath hydrogen test because it needs repeated measurements of blood [[glucose]] level | ||
*** False negative results: | *** False negative results: | ||
**** Diabetes | **** [[Diabetes]] | ||
**** [[Small bowel bacterial overgrowth syndrome|Bacterial overgrowth]] | **** [[Small bowel bacterial overgrowth syndrome|Bacterial overgrowth]] | ||
** Genetic test for primary lactase deficiency <ref name="pmid15479673">{{cite journal |vauthors=Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL |title=A genetic test which can be used to diagnose adult-type hypolactasia in children |journal=Gut |volume=53 |issue=11 |pages=1571–6 |year=2004 |pmid=15479673 |pmc=1774274 |doi=10.1136/gut.2004.040048 |url=}}</ref> | ** Genetic test for primary lactase deficiency <ref name="pmid15479673">{{cite journal |vauthors=Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL |title=A genetic test which can be used to diagnose adult-type hypolactasia in children |journal=Gut |volume=53 |issue=11 |pages=1571–6 |year=2004 |pmid=15479673 |pmc=1774274 |doi=10.1136/gut.2004.040048 |url=}}</ref> | ||
*** Acquired primary lactase deficiency is associated with a CC [[genotype]] at -13.9 kb upstream of the lactase gene and [[lactase]] persistence is related to TT [[genotype]]. | *** Acquired primary lactase deficiency is associated with a CC [[genotype]] at -13.9 kb upstream of the [[lactase]] gene and [[lactase]] persistence is related to TT [[genotype]]. | ||
==References== | ==References== | ||
Revision as of 18:28, 12 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]
Overview
Lactose intolerance test may be helpful in the diagnosis of lactose intolerance. Findings suggestive of lactose intolerance include bloating, diarrhea and abdominal pain and rising of blood glucose by less than 20 mg/dL after ingestion of lactose. Genetic test can also be used for diagnosis of primary lactase deficiency that is associated with CC genotype at -13.9 kb upstream of the lactase gene.
Other Diagnostic Studies
- Other diagnostic studies for lactose intolerance include:
References
- ↑ Law D, Conklin J, Pimentel M (2010). "Lactose intolerance and the role of the lactose breath test". Am. J. Gastroenterol. 105 (8): 1726–8. doi:10.1038/ajg.2010.146. PMID 20686460.
- ↑ Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL (2004). "A genetic test which can be used to diagnose adult-type hypolactasia in children". Gut. 53 (11): 1571–6. doi:10.1136/gut.2004.040048. PMC 1774274. PMID 15479673.