Gastrointestinal stromal tumor natural history: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
*Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary.<ref>{{Cite web | title =Risk Assessment and Prognosis | |||
| url =http://www.cancer.gov/types/soft-tissue-sarcoma/hp/gist-treatment-pdq#section/_1 }}</ref> | |||
*Prognosis of GIST depends upon size, location, spread and mitotic rate of the tumor (mitoses per 50 high-power fields). | |||
| url =http://www.cancer.gov/types/soft-tissue-sarcoma/hp/gist-treatment-pdq#section/_1 }}</ref> | |||
*Prognosis of GIST depends upon size, location, spread and mitotic rate of the tumor. | |||
**Patients with gastric GIST have been reported to have better outlook as compared to patients with extragastric GIST. | **Patients with gastric GIST have been reported to have better outlook as compared to patients with extragastric GIST. | ||
**Patients with localized primary disease have a average survival period of 5 years. | **Patients with localized primary disease have a average survival period of 5 years. | ||
Revision as of 16:46, 15 December 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
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Gastrointestinal stromal tumor Microchapters |
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Differentiating Gastrointestinal stromal tumor from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Gastrointestinal stromal tumor natural history On the Web |
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American Roentgen Ray Society Images of Gastrointestinal stromal tumor natural history |
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Directions to Hospitals Treating Gastrointestinal stromal tumor |
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Risk calculators and risk factors for Gastrointestinal stromal tumor natural history |
Overview
Most common site of involvement of GIST is stomach(70%).
Natural history
Common sites of involvement include:
- Stomach: 70%
- Small intestine: 20-25%
- Anorectum: 7%
- Oesophagus
GISTs occur not only anywhere along the gastrointestinal tract, but also in the mesentery, omentum and retroperitoneum, which is called extra-gastrointestinal GISTs. Metastatic lesions may also be seen in cases of malignant extra-gastrointestinal GISTs
Complications
- Gastrointestinal bleeding
- Bowel obstruction
- Bowel perforation
- Peritonitis
- Volvulus
- Intussusception
- Surgical complications associated with resection include:
Prognosis
- Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary.[1]
- Prognosis of GIST depends upon size, location, spread and mitotic rate of the tumor (mitoses per 50 high-power fields).
- Patients with gastric GIST have been reported to have better outlook as compared to patients with extragastric GIST.
- Patients with localized primary disease have a average survival period of 5 years.
- Patients with malignant lesions and metastasis have an average survival period of 1-2 years.
- Patients with mitotic rate of >10 per 50 HPF have an average survival period of 1.5-2 years
- Patients with mitotic rate <10 per HPF have an average survival period of 8 years.