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==[[Non-alcoholic fatty liver disease natural history, complications and prognosis|Natural History, Complications, and Prognosis]]==
==[[Non-alcoholic fatty liver disease natural history, complications and prognosis|Natural History, Complications, and Prognosis]]==
===Natural History===
*The symptoms of NAFLD usually develop in the fourth decade of life.
*With the raising concern of obesity and metabolic syndrome NAFLD is becoming the most common liver disease in the world.
*Our understanding of NAFLD natural history is evolving with extensive research and we can classify NAFLD further by prospectively collecting the data with well defined and well designed studies.  <ref name="pmid27003142">{{cite journal |vauthors=Goh GB, McCullough AJ |title=Natural History of Nonalcoholic Fatty Liver Disease |journal=Dig. Dis. Sci. |volume=61 |issue=5 |pages=1226–33 |year=2016 |pmid=27003142 |doi=10.1007/s10620-016-4095-4 |url=}}</ref>
*If left untreated, Patients with NAFLD may progress to develop NASH which is a more serious complication.
===Complications===
*Common complications of NAFLD include: <ref name="urlNonalcoholic Fatty Liver Disease Symptoms, Causes, and More">{{cite web |url=https://www.healthline.com/health/nonalcoholic-fatty-liver-disease#complications |title=Nonalcoholic Fatty Liver Disease Symptoms, Causes, and More |format= |work= |accessdate=}}</ref>
**NASH
**Cirrhosis
**Gastro intestinal bleeding
**Liver failure
**Liver cancer
===Prognosis===
*Prognosis is generally variable with NAFLD  patients.
*Depending on the NAFLD Activity Score (NAS) of the NAFLD at the time of diagnosis, the prognosis may vary.
*The presence of fibrosis in NAFLD patients is associated with a particularly poor prognosis.<ref name="urlPathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality - Younossi - 2011 - Hepatology - Wiley Online Library">{{cite web |url=http://onlinelibrary.wiley.com/doi/10.1002/hep.24268/abstract;jsessionid=B90F10C0CB20CCE0E66ACA4796BBB0A4.f04t01?systemMessage=Wiley+Online+Library+will+be+unavailable+on+2nd+Dec+2017+starting+from+0800+EST+%2F+1300+GMT+%2F+21.00+SGT+for+2.5+hours+due+to+urgent+server+maintenance.+Apologies+for+the+inconvenience. |title=Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality - Younossi - 2011 - Hepatology - Wiley Online Library |format= |work= |accessdate=}}</ref>
*[Subtype of disease/malignancy] is associated with the most favorable prognosis.
*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.


==Diagnosis==
==Diagnosis==

Revision as of 21:11, 15 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

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Synonyms and keywords: NASH, NAFLD, non alcoholic steatohepatitis

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

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