Gastrointestinal stromal tumor differential diagnosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Gastrointestinal stromal tumor}} | |||
{{CMG}};{{AE}}{{Akshun}}{{PSD}} | |||
==Overview== | ==Overview== | ||
Gastrointestinal stromal tumor must be differentiated from other gastrointestinal [[leiomyoma]], gastrointestinal [[leiomyosarcoma]], gastrointestinal [[lymphoma]] / [[gastric lymphoma]], gastrointestinal [[schwannoma]] and gastrointestinal [[carcinoid]]. | |||
Gastrointestinal stromal tumor must be differentiated from gastrointestinal [[leiomyoma]], gastrointestinal [[leiomyosarcoma]], gastrointestinal [[lymphoma]] / [[gastric lymphoma]], gastrointestinal [[schwannoma]] and gastrointestinal [[carcinoid]]. | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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*Gastrointestinal [[leiomyosarcoma]]: rare | *Gastrointestinal [[leiomyosarcoma]]: rare | ||
*Gastrointestinal [[lymphoma]] / [[gastric lymphoma]] | *Gastrointestinal [[lymphoma]] / [[gastric lymphoma]] | ||
*Gastrointestinal [[schwannoma]] | *Gastrointestinal [[schwannoma]]<ref name="pmid15215166">{{cite journal |vauthors=West RB, Corless CL, Chen X, Rubin BP, Subramanian S, Montgomery K, Zhu S, Ball CA, Nielsen TO, Patel R, Goldblum JR, Brown PO, Heinrich MC, van de Rijn M |title=The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status |journal=Am. J. Pathol. |volume=165 |issue=1 |pages=107–13 |year=2004 |pmid=15215166 |pmc=1618538 |doi=10.1016/S0002-9440(10)63279-8 |url=}}</ref> | ||
*Gastrointestinal [[carcinoid]]<ref>{{Cite web | title =Gastrointestinal stromal tumour | *Gastrointestinal [[carcinoid]]<ref>{{Cite web | title =Gastrointestinal stromal tumour | ||
| url = http://radiopaedia.org/articles/gastrointestinal-stromal-tumour-1}}</ref> | | url = http://radiopaedia.org/articles/gastrointestinal-stromal-tumour-1}}</ref> | ||
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|- | |- | ||
|Other | |Other | ||
Markers | |||
|Desmin positive | |Desmin positive | ||
in 1-2% | in 1-2% | ||
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|Keratin positive | |Keratin positive | ||
|S100 positive | |S100 positive | ||
|} | |} | ||
Revision as of 17:30, 18 December 2017
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Gastrointestinal stromal tumor Microchapters |
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Differentiating Gastrointestinal stromal tumor from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Gastrointestinal stromal tumor differential diagnosis On the Web |
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American Roentgen Ray Society Images of Gastrointestinal stromal tumor differential diagnosis |
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FDA on Gastrointestinal stromal tumor differential diagnosis |
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CDC on Gastrointestinal stromal tumor differential diagnosis |
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Gastrointestinal stromal tumor differential diagnosis in the news |
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Blogs on Gastrointestinal stromal tumor differential diagnosis |
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Directions to Hospitals Treating Gastrointestinal stromal tumor |
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Risk calculators and risk factors for Gastrointestinal stromal tumor differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]Parminder Dhingra, M.D. [3]
Overview
Gastrointestinal stromal tumor must be differentiated from other gastrointestinal leiomyoma, gastrointestinal leiomyosarcoma, gastrointestinal lymphoma / gastric lymphoma, gastrointestinal schwannoma and gastrointestinal carcinoid.
Differential Diagnosis
- Gastrointestinal leiomyoma:
- Most common in the esophagus, accounting for 75% of mesenchymal tumours
- Rare in the remainder of the gastrointestinal tract
- Gastrointestinal leiomyosarcoma: rare
- Gastrointestinal lymphoma / gastric lymphoma
- Gastrointestinal schwannoma[1]
- Gastrointestinal carcinoid[2]
| Marker | GIST | GI leiomyoma | GI Leiomyosarcoma | Schwannoma | GI carcinoma | Melanoma |
|---|---|---|---|---|---|---|
| CD117 | Positive (95%) | Negative | Negative | Negative | Positive (50%) | Positive |
| CD34 | Positive (70%) | Negative | Negative | Positive (33%) | Negative | negative |
| DOG 1 | Positive (95%) | Negative | Negative | Negative | Negative | Rare |
| Other
Markers |
Desmin positive
in 1-2% |
Desmin positive in
100% cases |
Desmin positive but
variable proportion |
GFAP positive | Keratin positive | S100 positive |
References
- ↑ West RB, Corless CL, Chen X, Rubin BP, Subramanian S, Montgomery K, Zhu S, Ball CA, Nielsen TO, Patel R, Goldblum JR, Brown PO, Heinrich MC, van de Rijn M (2004). "The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status". Am. J. Pathol. 165 (1): 107–13. doi:10.1016/S0002-9440(10)63279-8. PMC 1618538. PMID 15215166.
- ↑ "Gastrointestinal stromal tumour".