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{{Infobox_gene}}
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'''[[S100 protein|S100]] calcium-binding protein A12''' ('''S100A12''') is a [[protein]] that in humans is encoded by the ''S100A12'' [[gene]].<ref name="pmid8985590">{{cite journal |vauthors=Wicki R, Marenholz I, Mischke D, Schafer BW, Heizmann CW | title = Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21 | journal = Cell Calcium | volume = 20 | issue = 6 | pages = 459–64 |date=Mar 1997 | pmid = 8985590 | pmc =  | doi =10.1016/S0143-4160(96)90087-1  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: S100A12 S100 calcium binding protein A12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6283| accessdate = }}</ref> It is also known as [[calgranulin]] C.
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{{GNF_Protein_box
| image = PBB_Protein_S100A12_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e8a.
| PDB = {{PDB2|1e8a}}, {{PDB2|1gqm}}, {{PDB2|1odb}}
| Name = S100 calcium binding protein A12
| HGNCid = 10489
| Symbol = S100A12
| AltSymbols =; MRP6; CGRP; p6; CAAF1; CAGC; ENRAGE
| OMIM = 603112
| ECnumber =
| Homologene = 48361
| MGIid =
| GeneAtlas_image1 = PBB_GE_S100A12_205863_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
  | Component = {{GNF_GO|id=GO:0005626 |text = insoluble fraction}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0050832 |text = defense response to fungus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6283
    | Hs_Ensembl = ENSG00000163221
    | Hs_RefseqProtein = NP_005612
    | Hs_RefseqmRNA = NM_005621
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 151612808
    | Hs_GenLoc_end = 151614749
    | Hs_Uniprot = P80511
    | Mm_EntrezGene = 
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''S100 calcium binding protein A12''', also known as '''S100A12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: S100A12 S100 calcium binding protein A12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6283| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.  This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.<ref name="entrez">{{cite web | title = Entrez Gene: S100A12 S100 calcium binding protein A12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6283| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.  This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Roth J, Vogl T, Sorg C, Sunderkötter C |title=Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. |journal=Trends Immunol. |volume=24 |issue= 4 |pages= 155-8 |year= 2004 |pmid= 12697438 |doi=  }}
*{{cite journal  |vauthors=Roth J, Vogl T, Sorg C, Sunderkötter C |title=Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules |journal=Trends Immunol. |volume=24 |issue= 4 |pages= 155–8 |year= 2004 |pmid= 12697438 |doi=10.1016/S1471-4906(03)00062-0 }}
*{{cite journal  | author=Guignard F, Mauel J, Markert M |title=Identification and characterization of a novel human neutrophil protein related to the S100 family. |journal=Biochem. J. |volume=309 ( Pt 2) |issue=  |pages= 395-401 |year= 1995 |pmid= 7626002 |doi=  }}
*{{cite journal  |vauthors=Guignard F, Mauel J, Markert M |title=Identification and characterization of a novel human neutrophil protein related to the S100 family |journal=Biochem. J. |volume=309 |issue=  2|pages= 395–401 |year= 1995 |pmid= 7626002 |doi= | pmc=1135745 }}
*{{cite journal  | author=Schäfer BW, Wicki R, Engelkamp D, ''et al.'' |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638-43 |year= 1995 |pmid= 7759097 |doi= }}
*{{cite journal  | author=Schäfer BW |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=10.1016/0888-7543(95)80005-7 |name-list-format=vanc| author2=Wicki R  | author3=Engelkamp D  | display-authors=3  | last4=Mattei  | first4=M  | last5=Heizmann  | first5=C }}
*{{cite journal | author=Yamamura T, Hitomi J, Nagasaki K, ''et al.'' |title=Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping. |journal=Biochem. Biophys. Res. Commun. |volume=221 |issue= 2 |pages= 356-60 |year= 1996 |pmid= 8619860 |doi=  }}
*{{cite journal  | author=Yamamura T |title=Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping |journal=Biochem. Biophys. Res. Commun. |volume=221 |issue= 2 |pages= 356–60 |year= 1996 |pmid= 8619860 |doi=10.1006/bbrc.1996.0600  |name-list-format=vanc| author2=Hitomi J  | author3=Nagasaki K  | display-authors=3  | last4=Suzuki  | first4=M  | last5=Takahashi  | first5=E  | last6=Saito  | first6=S  | last7=Tsukada  | first7=T  | last8=Yamaguchi  | first8=K  }}
*{{cite journal  | author=Marti T, Erttmann KD, Gallin MY |title=Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. |journal=Biochem. Biophys. Res. Commun. |volume=221 |issue= 2 |pages= 454-8 |year= 1996 |pmid= 8619876 |doi= 10.1006/bbrc.1996.0616 }}
*{{cite journal  |vauthors=Marti T, Erttmann KD, Gallin MY |title=Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin |journal=Biochem. Biophys. Res. Commun. |volume=221 |issue= 2 |pages= 454–8 |year= 1996 |pmid= 8619876 |doi= 10.1006/bbrc.1996.0616 }}
*{{cite journal  | author=Ilg EC, Troxler H, Bürgisser DM, ''et al.'' |title=Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 146-50 |year= 1996 |pmid= 8769108 |doi= 10.1006/bbrc.1996.1144 }}
*{{cite journal  | author=Ilg EC |title=Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 146–50 |year= 1996 |pmid= 8769108 |doi= 10.1006/bbrc.1996.1144 |name-list-format=vanc| author2=Troxler H  | author3=Bürgisser DM  | display-authors=3  | last4=Kuster  | first4=T  | last5=Markert  | first5=M  | last6=Guignard  | first6=F  | last7=Hunziker  | first7=P  | last8=Birchler  | first8=N  | last9=Heizmann | first9=CW }}
*{{cite journal  | author=Wicki R, Marenholz I, Mischke D, ''et al.'' |title=Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. |journal=Cell Calcium |volume=20 |issue= 6 |pages= 459-64 |year= 1997 |pmid= 8985590 |doi= }}
*{{cite journal  | author=Hofmann MA |title=RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides |journal=Cell |volume=97 |issue= 7 |pages= 889–901 |year= 1999 |pmid= 10399917 |doi=10.1016/S0092-8674(00)80801-6 |name-list-format=vanc| author2=Drury S | author3=Fu C  | display-authors=3  | last4=Qu  | first4=Wu  | last5=Taguchi  | first5=Akihiko  | last6=Lu  | first6=Yan  | last7=Avila  | first7=Cecilia | last8=Kambham  | first8=Neeraja  | last9=Bierhaus  | first9=Angelika  }}
*{{cite journal  | author=Hofmann MA, Drury S, Fu C, ''et al.'' |title=RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. |journal=Cell |volume=97 |issue= 7 |pages= 889-901 |year= 1999 |pmid= 10399917 |doi= }}
*{{cite journal  | author=Moroz OV |title=Crystallization and preliminary X-ray diffraction analysis of human calcium-binding protein S100A12 |journal=Acta Crystallogr. D |volume=56 |issue= Pt 2 |pages= 189–91 |year= 2000 |pmid= 10666601 |doi=10.1107/S0907444999014936 |name-list-format=vanc| author2=Antson AA | author3=Dodson GG  | display-authors=3  | last4=Wilson  | first4=Keith S. | last5=Skibshøj  | first5=Inge  | last6=Lukanidin  | first6=Eugene M.  | last7=Bronstein  | first7=Igor B. }}
*{{cite journal | author=Moroz OV, Antson AA, Dodson GG, ''et al.'' |title=Crystallization and preliminary X-ray diffraction analysis of human calcium-binding protein S100A12. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=56 |issue= Pt 2 |pages= 189-91 |year= 2000 |pmid= 10666601 |doi=  }}
*{{cite journal  | author=Moroz OV |title=The three-dimensional structure of human S100A12 |journal=Acta Crystallogr. D |volume=57 |issue= Pt 1 |pages= 20–9 |year= 2001 |pmid= 11134923 |doi=10.1107/S090744490001458X  |name-list-format=vanc| author2=Antson AA  | author3=Murshudov GN  | display-authors=3  | last4=Maitland  | first4=Norman J.  | last5=Dodson  | first5=G. Guy  | last6=Wilson  | first6=Keith S.  | last7=Skibshøj  | first7=Inge  | last8=Lukanidin  | first8=Eugene M. | last9=Bronstein  | first9=Igor B. }}
*{{cite journal  | author=Moroz OV, Antson AA, Murshudov GN, ''et al.'' |title=The three-dimensional structure of human S100A12. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=57 |issue= Pt 1 |pages= 20-9 |year= 2001 |pmid= 11134923 |doi=  }}
*{{cite journal  | author=Cole AM |title=Calcitermin, a novel antimicrobial peptide isolated from human airway secretions |journal=FEBS Lett. |volume=504 |issue= 1–2 |pages= 5–10 |year= 2001 |pmid= 11522286 |doi=10.1016/S0014-5793(01)02731-4 |name-list-format=vanc| author2=Kim YH  | author3=Tahk S  | display-authors=3  | last4=Hong  | first4=T  | last5=Weis  | first5=P  | last6=Waring  | first6=AJ  | last7=Ganz  | first7=T  }}
*{{cite journal | author=Cole AM, Kim YH, Tahk S, ''et al.'' |title=Calcitermin, a novel antimicrobial peptide isolated from human airway secretions. |journal=FEBS Lett. |volume=504 |issue= 1-2 |pages= 5-10 |year= 2001 |pmid= 11522286 |doi=  }}
*{{cite journal  | author=Moroz OV |title=The structure of S100A12 in a hexameric form and its proposed role in receptor signalling |journal=Acta Crystallogr. D |volume=58 |issue= Pt 3 |pages= 407–13 |year= 2002 |pmid= 11856825 |doi=10.1107/S0907444901021278 |name-list-format=vanc| author2=Antson AA | author3=Dodson EJ  | display-authors=3  | last4=Burrell  | first4=H. J. | last5=Grist  | first5=S. J. | last6=Lloyd  | first6=R. M.  | last7=Maitland  | first7=N. J.  | last8=Dodson  | first8=G. G.  | last9=Wilson  | first9=K. S.  }}
*{{cite journal  | author=Moroz OV, Antson AA, Dodson EJ, ''et al.'' |title=The structure of S100A12 in a hexameric form and its proposed role in receptor signalling. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=58 |issue= Pt 3 |pages= 407-13 |year= 2002 |pmid= 11856825 |doi=  }}
*{{cite journal  | author=Strauss GI |title=Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure |journal=Neuropeptides |volume=35 |issue= 3–4 |pages= 174–80 |year= 2002 |pmid= 11884208 |doi= 10.1054/npep.2001.0861  |name-list-format=vanc| author2=Edvinsson L  | author3=Larsen FS  | display-authors=3  | last4=Møller  | first4=K  | last5=Knudsen  | first5=GM }}
*{{cite journal | author=Strauss GI, Edvinsson L, Larsen FS, ''et al.'' |title=Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. |journal=Neuropeptides |volume=35 |issue= 3-4 |pages= 174-80 |year= 2002 |pmid= 11884208 |doi= 10.1054/npep.2001.0861 }}
*{{cite journal  |vauthors=Maayan C, Becker Y, Gesundheit B, Girgis SI |title=Calcitonin gene related peptide in familial dysautonomia |journal=Neuropeptides |volume=35 |issue= 3–4 |pages= 189–95 |year= 2002 |pmid= 11884210 |doi= 10.1054/npep.2001.0863 }}
*{{cite journal  | author=Maayan C, Becker Y, Gesundheit B, Girgis SI |title=Calcitonin gene related peptide in familial dysautonomia. |journal=Neuropeptides |volume=35 |issue= 3-4 |pages= 189-95 |year= 2002 |pmid= 11884210 |doi= 10.1054/npep.2001.0863 }}
*{{cite journal  |vauthors=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848–52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200 }}
*{{cite journal  | author=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848-52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200 }}
*{{cite journal  | author=Ryckman C |title=HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes |journal=J. Immunol. |volume=169 |issue= 6 |pages= 3307–13 |year= 2002 |pmid= 12218151 |doi=  10.4049/jimmunol.169.6.3307|name-list-format=vanc| author2=Robichaud GA  | author3=Roy J  | display-authors=3  | last4=Cantin  | first4=R  | last5=Tremblay  | first5=MJ  | last6=Tessier  | first6=PA  }}
*{{cite journal  | author=Ryckman C, Robichaud GA, Roy J, ''et al.'' |title=HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes. |journal=J. Immunol. |volume=169 |issue= 6 |pages= 3307-13 |year= 2002 |pmid= 12218151 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Foell D |title=S100A12 (EN-RAGE) in monitoring Kawasaki disease |journal=Lancet |volume=361 |issue= 9365 |pages= 1270–2 |year= 2003 |pmid= 12699958 |doi=10.1016/S0140-6736(03)12986-8  |name-list-format=vanc| author2=Ichida F  | author3=Vogl T  | display-authors=3  | last4=Yu  | first4=Xianyi  | last5=Chen  | first5=Rui  | last6=Miyawaki  | first6=Toshio  | last7=Sorg  | first7=Clemens  | last8=Roth  | first8=Johannes  }}
*{{cite journal  | author=Foell D, Ichida F, Vogl T, ''et al.'' |title=S100A12 (EN-RAGE) in monitoring Kawasaki disease. |journal=Lancet |volume=361 |issue= 9365 |pages= 1270-2 |year= 2003 |pmid= 12699958 |doi=  }}
*{{cite journal  | author=Foell D |title=Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease |journal=Gut |volume=52 |issue= 6 |pages= 847–53 |year= 2003 |pmid= 12740341 |doi=10.1136/gut.52.6.847  | pmc=1773692  |name-list-format=vanc| author2=Kucharzik T  | author3=Kraft M  | display-authors=3  | last4=Vogl  | first4=T  | last5=Sorg  | first5=C  | last6=Domschke  | first6=W  | last7=Roth  | first7=J }}
*{{cite journal | author=Foell D, Kucharzik T, Kraft M, ''et al.'' |title=Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease. |journal=Gut |volume=52 |issue= 6 |pages= 847-53 |year= 2003 |pmid= 12740341 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6283}}
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[[Category:S100 proteins]]
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Revision as of 05:49, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene.[1][2] It is also known as calgranulin C.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.[2]

References

  1. ↑ Wicki R, Marenholz I, Mischke D, Schafer BW, Heizmann CW (Mar 1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.
  2. ↑ 2.0 2.1 "Entrez Gene: S100A12 S100 calcium binding protein A12".

Further reading



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