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{{Infobox_gene}}
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'''Protein Wnt-3a''' is a [[protein]] that in humans is encoded by the ''WNT3A'' [[gene]].<ref name="pmid11414706">{{cite journal | vauthors = Saitoh T, Hirai M, Katoh M | title = Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region | journal = Biochem Biophys Res Commun | volume = 284 | issue = 5 | pages = 1168–75 |date=Jun 2001 | pmid = 11414706 | pmc =  | doi = 10.1006/bbrc.2001.5105 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89780| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Wingless-type MMTV integration site family, member 3A
| HGNCid = 15983
| Symbol = WNT3A
| AltSymbols =; MGC119418; MGC119419; MGC119420
| OMIM = 606359
| ECnumber = 
| Homologene = 22528
| MGIid = 98956
| GeneAtlas_image1 = PBB_GE_WNT3A_gnf1h01091_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
  | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001756 |text = somitogenesis}} {{GNF_GO|id=GO:0001947 |text = heart looping}} {{GNF_GO|id=GO:0007223 |text = Wnt receptor signaling pathway, calcium modulating pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030879 |text = mammary gland development}} {{GNF_GO|id=GO:0042472 |text = inner ear morphogenesis}} {{GNF_GO|id=GO:0045595 |text = regulation of cell differentiation}} {{GNF_GO|id=GO:0048103 |text = somatic stem cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 89780
    | Hs_Ensembl = ENSG00000154342
    | Hs_RefseqProtein = NP_149122
    | Hs_RefseqmRNA = NM_033131
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 226261375
    | Hs_GenLoc_end = 226315584
    | Hs_Uniprot = P56704
    | Mm_EntrezGene = 22416
    | Mm_Ensembl = ENSMUSG00000009900
    | Mm_RefseqmRNA = NM_009522
    | Mm_RefseqProtein = NP_033548
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 59064228
    | Mm_GenLoc_end = 59106947
    | Mm_Uniprot = Q5SQV7
  }}
}}
'''Wingless-type MMTV integration site family, member 3A''', also known as '''WNT3A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89780| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.<ref name="entrez">{{cite web | title = Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89780| accessdate = }}</ref>
| summary_text = The WNT gene family consists of structurally related genes that encode secreted [[signaling proteins]]. These proteins have been implicated in [[oncogenesis]], [[adipogenesis]] etc<ref>{{cite journal|url=http://www.jbc.org/content/280/25/24004|title=Wnt Signaling Inhibits Adipogenesis through β-Catenin-dependent and -independent Mechanisms|first1=Jennifer A.|last1=Kennell|first2=Ormond A.|last2=MacDougald|date=24 June 2005|publisher=|journal=Journal of Biological Chemistry|volume=280|issue=25|pages=24004–24010|via=www.jbc.org|doi=10.1074/jbc.M501080200|pmid=15849360}}</ref> and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface. |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267-75 |year= 1994 |pmid= 8167409 |doi=  }}
*{{cite journal  | vauthors=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface. |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267–75 |year= 1994 |pmid= 8167409 |doi= 10.1091/mbc.4.12.1267| pmc=275763 }}
*{{cite journal | author=Huguet EL, McMahon JA, McMahon AP, ''et al.'' |title=Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. |journal=Cancer Res. |volume=54 |issue= 10 |pages= 2615-21 |year= 1994 |pmid= 8168088 |doi=  }}
*{{cite journal   |vauthors=Huguet EL, McMahon JA, McMahon AP, etal |title=Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. |journal=Cancer Res. |volume=54 |issue= 10 |pages= 2615–21 |year= 1994 |pmid= 8168088 |doi=  }}
*{{cite journal | author=Gazit A, Yaniv A, Bafico A, ''et al.'' |title=Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. |journal=Oncogene |volume=18 |issue= 44 |pages= 5959-66 |year= 1999 |pmid= 10557084 |doi= 10.1038/sj.onc.1202985 }}
*{{cite journal   |vauthors=Gazit A, Yaniv A, Bafico A, etal |title=Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. |journal=Oncogene |volume=18 |issue= 44 |pages= 5959–66 |year= 1999 |pmid= 10557084 |doi= 10.1038/sj.onc.1202985 }}
*{{cite journal | author=Tanaka K, Okabayashi K, Asashima M, ''et al.'' |title=The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. |journal=Eur. J. Biochem. |volume=267 |issue= 13 |pages= 4300-11 |year= 2000 |pmid= 10866835 |doi=  }}
*{{cite journal   |vauthors=Tanaka K, Okabayashi K, Asashima M, etal |title=The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. |journal=Eur. J. Biochem. |volume=267 |issue= 13 |pages= 4300–11 |year= 2000 |pmid= 10866835 |doi=10.1046/j.1432-1033.2000.01478.x }}
*{{cite journal  | author=Saitoh T, Hirai M, Katoh M |title=Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 5 |pages= 1168-75 |year= 2001 |pmid= 11414706 |doi= 10.1006/bbrc.2001.5105 }}
*{{cite journal  | author=Katoh M |title=Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. |journal=Int. J. Oncol. |volume=20 |issue= 2 |pages= 373–7 |year= 2002 |pmid= 11788904 |doi= 10.3892/ijo.20.2.373}}
*{{cite journal  | author=Katoh M |title=Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. |journal=Int. J. Oncol. |volume=20 |issue= 2 |pages= 373-7 |year= 2002 |pmid= 11788904 |doi=  }}
*{{cite journal  | author=Katoh M |title=Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster. |journal=Int. J. Mol. Med. |volume=9 |issue= 3 |pages= 221–7 |year= 2002 |pmid= 11836627 |doi=  10.3892/ijmm.9.3.221}}
*{{cite journal | author=Katoh M |title=Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster. |journal=Int. J. Mol. Med. |volume=9 |issue= 3 |pages= 221-7 |year= 2002 |pmid= 11836627 |doi= }}
*{{cite journal   |vauthors=Filali M, Cheng N, Abbott D, etal |title=Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33398–410 |year= 2002 |pmid= 12052822 |doi= 10.1074/jbc.M107977200 }}
*{{cite journal  | author=Filali M, Cheng N, Abbott D, ''et al.'' |title=Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33398-410 |year= 2002 |pmid= 12052822 |doi= 10.1074/jbc.M107977200 }}
*{{cite journal  | vauthors=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4  }}
*{{cite journal | author=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 185-9 |year= 2002 |pmid= 12067714 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Hino S, Michiue T, Asashima M, Kikuchi A |title=Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14066–73 |year= 2003 |pmid= 12556519 |doi= 10.1074/jbc.M213265200 }}
*{{cite journal  | author=Hino S, Michiue T, Asashima M, Kikuchi A |title=Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14066-73 |year= 2003 |pmid= 12556519 |doi= 10.1074/jbc.M213265200 }}
*{{cite journal  | vauthors=Qiang YW, Endo Y, Rubin JS, Rudikoff S |title=Wnt signaling in B-cell neoplasia. |journal=Oncogene |volume=22 |issue= 10 |pages= 1536–45 |year= 2003 |pmid= 12629517 |doi= 10.1038/sj.onc.1206239 }}
*{{cite journal | author=Qiang YW, Endo Y, Rubin JS, Rudikoff S |title=Wnt signaling in B-cell neoplasia. |journal=Oncogene |volume=22 |issue= 10 |pages= 1536-45 |year= 2003 |pmid= 12629517 |doi= 10.1038/sj.onc.1206239 }}
*{{cite journal   |vauthors=Hocevar BA, Mou F, Rennolds JL, etal |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2). |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084–94 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286  | pmc=162138 }}
*{{cite journal  | author=Hocevar BA, Mou F, Rennolds JL, ''et al.'' |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2). |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084-94 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286 }}
*{{cite journal  | vauthors=Liu G, Bafico A, Harris VK, Aaronson SA  | author4-link=Stuart A. Aaronson  |title=A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5825–35 |year= 2003 |pmid= 12897152 |doi=10.1128/MCB.23.16.5825-5835.2003  | pmc=166321  }}
*{{cite journal | author=Liu G, Bafico A, Harris VK, Aaronson SA |title=A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5825-35 |year= 2003 |pmid= 12897152 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Swiatek W, Tsai IC, Klimowski L, etal |title=Regulation of casein kinase I epsilon activity by Wnt signaling. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 13011–7 |year= 2004 |pmid= 14722104 |doi= 10.1074/jbc.M304682200 }}
*{{cite journal  | author=Swiatek W, Tsai IC, Klimowski L, ''et al.'' |title=Regulation of casein kinase I epsilon activity by Wnt signaling. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 13011-7 |year= 2004 |pmid= 14722104 |doi= 10.1074/jbc.M304682200 }}
*{{cite journal  | vauthors=Zilberberg A, Yaniv A, Gazit A |title=The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17535–42 |year= 2004 |pmid= 14739301 |doi= 10.1074/jbc.M311292200 }}
*{{cite journal  | author=Zilberberg A, Yaniv A, Gazit A |title=The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17535-42 |year= 2004 |pmid= 14739301 |doi= 10.1074/jbc.M311292200 }}
*{{cite journal  | vauthors=Lu W, Yamamoto V, Ortega B, Baltimore D |title=Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. |journal=Cell |volume=119 |issue= 1 |pages= 97–108 |year= 2004 |pmid= 15454084 |doi= 10.1016/j.cell.2004.09.019 }}
*{{cite journal | author=Lu W, Yamamoto V, Ortega B, Baltimore D |title=Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. |journal=Cell |volume=119 |issue= 1 |pages= 97-108 |year= 2004 |pmid= 15454084 |doi= 10.1016/j.cell.2004.09.019 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Capurro MI, Shi W, Sandal S, Filmus J |title=Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41201–6 |year= 2006 |pmid= 16227623 |doi= 10.1074/jbc.M507004200 }}
*{{cite journal  | author=Capurro MI, Shi W, Sandal S, Filmus J |title=Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41201-6 |year= 2006 |pmid= 16227623 |doi= 10.1074/jbc.M507004200 }}
*{{cite journal  | vauthors=Thrasivoulou C, Millar M, Ahmed A | last-author-amp=yes | title=Activation of intracellular calcium by multiple Wnt ligands and translocation of  ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways |  journal = J. Biol. Chem. |volume=288 |issue= 50 |pages= 35651–35659 |year= 2013 |pmid=  24158438 |doi=10.1074/jbc.M112.437913 | pmc=3861617}}
}}
}}
{{refend}}
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Latest revision as of 22:45, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis etc[3] and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.[2]

References

  1. ↑ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region". Biochem Biophys Res Commun. 284 (5): 1168–75. doi:10.1006/bbrc.2001.5105. PMID 11414706.
  2. ↑ 2.0 2.1 "Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A".
  3. ↑ Kennell, Jennifer A.; MacDougald, Ormond A. (24 June 2005). "Wnt Signaling Inhibits Adipogenesis through β-Catenin-dependent and -independent Mechanisms". Journal of Biological Chemistry. 280 (25): 24004–24010. doi:10.1074/jbc.M501080200. PMID 15849360 – via www.jbc.org.

Further reading



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