CYP4B1: Difference between revisions

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{{Infobox_gene}}
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'''Cytochrome P450 4B1''' is a [[protein]] that in humans is encoded by the ''CYP4B1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1580| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cytochrome P450, family 4, subfamily B, polypeptide 1
| HGNCid = 2644
| Symbol = CYP4B1
| AltSymbols =; P-450HP
| OMIM = 124075
| ECnumber = 
| Homologene = 73900
| MGIid = 103225
| GeneAtlas_image1 = PBB_GE_CYP4B1_210096_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1580
    | Hs_Ensembl = ENSG00000142973
    | Hs_RefseqProtein = NP_000770
    | Hs_RefseqmRNA = NM_000779
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 47037305
    | Hs_GenLoc_end = 47057672
    | Hs_Uniprot = P13584
    | Mm_EntrezGene = 13120
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_007823
    | Mm_RefseqProtein = NP_031849
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
{{SI}}
 
 
'''Cytochrome P450, family 4, subfamily B, polypeptide 1''', also known as '''CYP4B1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1580| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1580| accessdate = }}</ref>
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.<ref name="entrez" />
}}
}}
{| class="wikitable" style="background:white"
|+ Mouse Mutant Alleles for Cyp4b1
|-
| Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the [http://informatics.jax.org MGI]
| [http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=23183 Cyp4b1]
|-
| Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse.
| [http://www.knockoutmouse.org/genedetails/MGI:103225 CYP4B1<sup>tm1a(KOMP)Wtsi</sup>]
|-
| colspan=2 | '''Example structure of targeted conditional mutant allele for this gene'''
|-
| colspan=2 | [[File:Cyp4b1 tm1a(KOMP)Wtsi.jpg|650px|Molecular structure of Cyp4b1 region with inserted mutation sequence]]
|-
| colspan=2 | These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Cyp4b1:
see [[Knockout mouse]]
|}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CYP4B1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|30em}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Windmill KF, McKinnon RA, Zhu X, ''et al.'' |title=The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. |journal=Mutat. Res. |volume=376 |issue= 1-2 |pages= 153-60 |year= 1997 |pmid= 9202751 |doi=  }}
*{{cite journal  | vauthors=Windmill KF, McKinnon RA, Zhu X |title=The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. |journal=Mutat. Res. |volume=376 |issue= 1-2 |pages= 153–60 |year= 1997 |pmid= 9202751 |doi=10.1016/S0027-5107(97)00038-9 |display-authors=etal}}
*{{cite journal  | author=Hakkola J, Pelkonen O, Pasanen M, Raunio H |title=Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity. |journal=Crit. Rev. Toxicol. |volume=28 |issue= 1 |pages= 35-72 |year= 1998 |pmid= 9493761 |doi=  }}
*{{cite journal  | vauthors=Hakkola J, Pelkonen O, Pasanen M, Raunio H |title=Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity. |journal=Crit. Rev. Toxicol. |volume=28 |issue= 1 |pages= 35–72 |year= 1998 |pmid= 9493761 |doi=10.1080/10408449891344173 }}
*{{cite journal  | author=Yokotani N, Sogawa K, Matsubara S, ''et al.'' |title=cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression. |journal=Eur. J. Biochem. |volume=187 |issue= 1 |pages= 23-9 |year= 1990 |pmid= 2298205 |doi=  }}
*{{cite journal  | vauthors=Yokotani N, Sogawa K, Matsubara S |title=cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression. |journal=Eur. J. Biochem. |volume=187 |issue= 1 |pages= 23–9 |year= 1990 |pmid= 2298205 |doi=10.1111/j.1432-1033.1990.tb15273.x |display-authors=etal}}
*{{cite journal  | author=Nhamburo PT, Gonzalez FJ, McBride OW, ''et al.'' |title=Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping. |journal=Biochemistry |volume=28 |issue= 20 |pages= 8060-6 |year= 1990 |pmid= 2574990 |doi=  }}
*{{cite journal  | vauthors=Nhamburo PT, Gonzalez FJ, McBride OW |title=Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping. |journal=Biochemistry |volume=28 |issue= 20 |pages= 8060–6 |year= 1990 |pmid= 2574990 |doi=10.1021/bi00446a014 |display-authors=etal}}
*{{cite journal  | author=McKinnon RA, Burgess WM, Gonzalez FJ, ''et al.'' |title=Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues. |journal=Pharmacogenetics |volume=4 |issue= 5 |pages= 260-70 |year= 1995 |pmid= 7894498 |doi=  }}
*{{cite journal  | vauthors=McKinnon RA, Burgess WM, Gonzalez FJ |title=Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues. |journal=Pharmacogenetics |volume=4 |issue= 5 |pages= 260–70 |year= 1995 |pmid= 7894498 |doi=10.1097/00008571-199410000-00004 |display-authors=etal}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ |title=Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. |journal=Cancer Res. |volume=54 |issue= 4 |pages= 1085-91 |year= 1994 |pmid= 8313365 |doi=  }}
*{{cite journal  | vauthors=Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ |title=Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. |journal=Cancer Res. |volume=54 |issue= 4 |pages= 1085–91 |year= 1994 |pmid= 8313365 |doi=  }}
*{{cite journal  | author=Hakkola J, Raunio H, Purkunen R, ''et al.'' |title=Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. |journal=Biochem. Pharmacol. |volume=52 |issue= 2 |pages= 379-83 |year= 1996 |pmid= 8694864 |doi=  }}
*{{cite journal  | vauthors=Hakkola J, Raunio H, Purkunen R |title=Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. |journal=Biochem. Pharmacol. |volume=52 |issue= 2 |pages= 379–83 |year= 1996 |pmid= 8694864 |doi=10.1016/0006-2952(96)00216-X |display-authors=etal}}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Hukkanen J, Hakkola J, Anttila S, ''et al.'' |title=Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes. |journal=Mol. Carcinog. |volume=20 |issue= 2 |pages= 224-30 |year= 1997 |pmid= 9364212 |doi=  }}
*{{cite journal  | vauthors=Hukkanen J, Hakkola J, Anttila S |title=Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes. |journal=Mol. Carcinog. |volume=20 |issue= 2 |pages= 224–30 |year= 1997 |pmid= 9364212 |doi=10.1002/(SICI)1098-2744(199710)20:2<224::AID-MC9>3.0.CO;2-M |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Hukkanen J, Mäntylä M, Kangas L, ''et al.'' |title=Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium. |journal=Pharmacol. Toxicol. |volume=82 |issue= 2 |pages= 93-7 |year= 1998 |pmid= 9498238 |doi=  }}
*{{cite journal  | vauthors=Hukkanen J, Mäntylä M, Kangas L |title=Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium. |journal=Pharmacol. Toxicol. |volume=82 |issue= 2 |pages= 93–7 |year= 1998 |pmid= 9498238 |doi=10.1111/j.1600-0773.1998.tb01404.x |display-authors=etal}}
*{{cite journal  | author=Thum T, Borlak J |title=Gene expression in distinct regions of the heart. |journal=Lancet |volume=355 |issue= 9208 |pages= 979-83 |year= 2000 |pmid= 10768437 |doi=  }}
*{{cite journal  | vauthors=Thum T, Borlak J |title=Gene expression in distinct regions of the heart. |journal=Lancet |volume=355 |issue= 9208 |pages= 979–83 |year= 2000 |pmid= 10768437 |doi=10.1016/S0140-6736(00)99016-0 }}
*{{cite journal  | author=Imaoka S, Yoneda Y, Sugimoto T, ''et al.'' |title=CYP4B1 is a possible risk factor for bladder cancer in humans. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 776-80 |year= 2000 |pmid= 11062028 |doi= 10.1006/bbrc.2000.3740 }}
*{{cite journal  | vauthors=Imaoka S, Yoneda Y, Sugimoto T |title=CYP4B1 is a possible risk factor for bladder cancer in humans. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 776–80 |year= 2000 |pmid= 11062028 |doi= 10.1006/bbrc.2000.3740 |display-authors=etal}}
*{{cite journal  | author=Henne KR, Kunze KL, Zheng YM, ''et al.'' |title=Covalent linkage of prosthetic heme to CYP4 family P450 enzymes. |journal=Biochemistry |volume=40 |issue= 43 |pages= 12925-31 |year= 2001 |pmid= 11669629 |doi=  }}
*{{cite journal  | vauthors=Henne KR, Kunze KL, Zheng YM |title=Covalent linkage of prosthetic heme to CYP4 family P450 enzymes. |journal=Biochemistry |volume=40 |issue= 43 |pages= 12925–31 |year= 2001 |pmid= 11669629 |doi=10.1021/bi011171z |display-authors=etal}}
*{{cite journal  | author=Finnström N, Bjelfman C, Söderström TG, ''et al.'' |title=Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR. |journal=Eur. J. Clin. Invest. |volume=31 |issue= 10 |pages= 880-6 |year= 2002 |pmid= 11737226 |doi=  }}
*{{cite journal  | vauthors=Finnström N, Bjelfman C, Söderström TG |title=Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR. |journal=Eur. J. Clin. Invest. |volume=31 |issue= 10 |pages= 880–6 |year= 2002 |pmid= 11737226 |doi=10.1046/j.1365-2362.2001.00893.x |display-authors=etal}}
*{{cite journal  | author=Iscan M, Klaavuniemi T, Coban T, ''et al.'' |title=The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. |journal=Breast Cancer Res. Treat. |volume=70 |issue= 1 |pages= 47-54 |year= 2002 |pmid= 11767004 |doi=  }}
*{{cite journal  | vauthors=Iscan M, Klaavuniemi T, Coban T |title=The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. |journal=Breast Cancer Res. Treat. |volume=70 |issue= 1 |pages= 47–54 |year= 2002 |pmid= 11767004 |doi=10.1023/A:1012526406741 |display-authors=etal}}
*{{cite journal  | author=Lo-Guidice JM, Allorge D, Cauffiez C, ''et al.'' |title=Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. |journal=Pharmacogenetics |volume=12 |issue= 5 |pages= 367-74 |year= 2003 |pmid= 12142726 |doi=  }}
*{{cite journal  | vauthors=Lo-Guidice JM, Allorge D, Cauffiez C |title=Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. |journal=Pharmacogenetics |volume=12 |issue= 5 |pages= 367–74 |year= 2003 |pmid= 12142726 |doi=10.1097/00008571-200207000-00004 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}
{{Cytochrome P450}}


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{{WH}}
{{gene-1-stub}}
{{WikiDoc Sources}}

Latest revision as of 02:05, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.[1]

Mouse Mutant Alleles for Cyp4b1
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI Cyp4b1
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. CYP4B1tm1a(KOMP)Wtsi
Example structure of targeted conditional mutant allele for this gene
Molecular structure of Cyp4b1 region with inserted mutation sequence
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Cyp4b1:

see Knockout mouse

References

  1. ↑ 1.0 1.1 "Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1".

External links

Further reading

  • Windmill KF, McKinnon RA, Zhu X, et al. (1997). "The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies". Mutat. Res. 376 (1–2): 153–60. doi:10.1016/S0027-5107(97)00038-9. PMID 9202751.
  • Hakkola J, Pelkonen O, Pasanen M, Raunio H (1998). "Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity". Crit. Rev. Toxicol. 28 (1): 35–72. doi:10.1080/10408449891344173. PMID 9493761.
  • Yokotani N, Sogawa K, Matsubara S, et al. (1990). "cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression". Eur. J. Biochem. 187 (1): 23–9. doi:10.1111/j.1432-1033.1990.tb15273.x. PMID 2298205.
  • Nhamburo PT, Gonzalez FJ, McBride OW, et al. (1990). "Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping". Biochemistry. 28 (20): 8060–6. doi:10.1021/bi00446a014. PMID 2574990.
  • McKinnon RA, Burgess WM, Gonzalez FJ, et al. (1995). "Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues". Pharmacogenetics. 4 (5): 260–70. doi:10.1097/00008571-199410000-00004. PMID 7894498.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ (1994). "Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors". Cancer Res. 54 (4): 1085–91. PMID 8313365.
  • Hakkola J, Raunio H, Purkunen R, et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy". Biochem. Pharmacol. 52 (2): 379–83. doi:10.1016/0006-2952(96)00216-X. PMID 8694864.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Hukkanen J, Hakkola J, Anttila S, et al. (1997). "Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes". Mol. Carcinog. 20 (2): 224–30. doi:10.1002/(SICI)1098-2744(199710)20:2<224::AID-MC9>3.0.CO;2-M. PMID 9364212.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hukkanen J, Mäntylä M, Kangas L, et al. (1998). "Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium". Pharmacol. Toxicol. 82 (2): 93–7. doi:10.1111/j.1600-0773.1998.tb01404.x. PMID 9498238.
  • Thum T, Borlak J (2000). "Gene expression in distinct regions of the heart". Lancet. 355 (9208): 979–83. doi:10.1016/S0140-6736(00)99016-0. PMID 10768437.
  • Imaoka S, Yoneda Y, Sugimoto T, et al. (2000). "CYP4B1 is a possible risk factor for bladder cancer in humans". Biochem. Biophys. Res. Commun. 277 (3): 776–80. doi:10.1006/bbrc.2000.3740. PMID 11062028.
  • Henne KR, Kunze KL, Zheng YM, et al. (2001). "Covalent linkage of prosthetic heme to CYP4 family P450 enzymes". Biochemistry. 40 (43): 12925–31. doi:10.1021/bi011171z. PMID 11669629.
  • Finnström N, Bjelfman C, Söderström TG, et al. (2002). "Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR". Eur. J. Clin. Invest. 31 (10): 880–6. doi:10.1046/j.1365-2362.2001.00893.x. PMID 11737226.
  • Iscan M, Klaavuniemi T, Coban T, et al. (2002). "The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue". Breast Cancer Res. Treat. 70 (1): 47–54. doi:10.1023/A:1012526406741. PMID 11767004.
  • Lo-Guidice JM, Allorge D, Cauffiez C, et al. (2003). "Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant". Pharmacogenetics. 12 (5): 367–74. doi:10.1097/00008571-200207000-00004. PMID 12142726.



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