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{{Infobox_gene}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''[[S100 protein|S100]] calcium-binding protein A11''' ('''S100A11''') is a [[protein]] that in humans is encoded by the ''S100A11'' [[gene]].<ref name="pmid8985590">{{cite journal | vauthors = Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW | title = Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21 | journal = Cell Calcium | volume = 20 | issue = 6 | pages = 459–64 | date = December 1996 | pmid = 8985590 | doi = 10.1016/S0143-4160(96)90087-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: S100A11 S100 calcium binding protein A11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6282| accessdate = }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = S100 calcium binding protein A11
| HGNCid = 10488
| Symbol = S100A11
| AltSymbols =; MLN70; S100C
| OMIM = 603114
| ECnumber = 
| Homologene = 55916
| MGIid = 3645720
| GeneAtlas_image1 = PBB_GE_S100A11_200660_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0048154 |text = S100 beta binding}} {{GNF_GO|id=GO:0048306 |text = calcium-dependent protein binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008156 |text = negative regulation of DNA replication}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6282
    | Hs_Ensembl = ENSG00000163191
    | Hs_RefseqProtein = NP_005611
    | Hs_RefseqmRNA = NM_005620
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 150271606
    | Hs_GenLoc_end = 150276135
    | Hs_Uniprot = P31949
    | Mm_EntrezGene = 277089
    | Mm_Ensembl = ENSMUSG00000066457
    | Mm_RefseqmRNA = XM_204772
    | Mm_RefseqProtein = XP_204772
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 74879980
    | Mm_GenLoc_end = 74880276
    | Mm_Uniprot = 
  }}
}}
'''S100 calcium binding protein A11''', also known as '''S100A11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: S100A11 S100 calcium binding protein A11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6282| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 [[EF hand|EF-hand]] calcium-binding motifs. S100 proteins are localized in the [[cytoplasm]] and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as [[cell cycle]] progression and differentiation.<ref name="pmid19649745">{{cite journal | vauthors = He H, Li J, Weng S, Li M, Yu Y | title = S100A11: diverse function and pathology corresponding to different target proteins | journal = Cell Biochemistry and Biophysics | volume = 55 | issue = 3 | pages = 117-26 | year = 2009 | pmid = 19649745 | doi = 10.1007/s12013-009-9061-8 }}</ref> S100A11 is localized in the cytoplasm of resting human keratinocytes in vitro.<ref name="pmid20872027">{{cite journal | vauthors = Sakaguchi M, Huh NH | title = S100A11, a dual growth regulator of epidermal keratinocytes | journal = Amino Acids | volume = 41 | issue = 4 | pages = 797-807 | date = October 2011 | pmid = 20872027 | doi = 10.1007/s00726-010-0747-4 }}</ref>
| section_title =  
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.<ref name="entrez">{{cite web | title = Entrez Gene: S100A11 S100 calcium binding protein A11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6282| accessdate = }}</ref>
}}


==References==
S100A11, along with all 13 members of the S100 family, are located as a cluster on chromosome 1q21. The protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.<ref name="entrez" />
{{reflist|2}}
 
==Further reading==
Suppression of S100A11 by small interfering RNA caused cells to [[apoptosis]], and overexpression of S100A11 has been found to inhibit apoptosis in tumor cells.<ref>{{cite journal | vauthors = Kanamori T, Takakura K, Mandai M, Kariya M, Fukuhara K, Sakaguchi M, Huh NH, Saito K, Sakurai T, Fujita J, Fujii S | title = Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours | journal = Molecular Human Reproduction | volume = 10 | issue = 10 | pages = 735-42 | date = October 2004 | pmid = 15322223 | doi = 10.1093/molehr/gah100 }}</ref> Furthermore, the knock-down of S100A11 via [[Small interfering RNA|siRNA]] reduces the [[Sister chromatid exchange|sister-chromatid exchange]] and the viability of cells.
 
[[Interleukin 8|IL-8]] and [[TNF-alpha]] induce S100A11 expression and release in chondrocytes in culture and exogenous S100A11 causes chondrocyte hypertrophy.<ref>{{cite journal | vauthors = Cecil DL, Johnson K, Rediske J, Lotz M, Schmidt AM, Terkeltaub R | title = Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products | journal = Journal of Immunology | volume = 175 | issue = 12 | pages = 8296-302 | date = December 2005 | pmid = 16339570 | doi = 10.4049/jimmunol.175.12.8296 }}</ref>
 
It has been shown that S100A11 enhances the recombination activity of human [[RAD51]] ''in vitro''. A knock-down leads to diffuse distribution of RAD54B.<ref>{{cite journal | vauthors = Murzik U, Hemmerich P, Weidtkamp-Peters S, Ulbricht T, Bussen W, Hentschel J, von Eggeling F, Melle C | title = Rad54B targeting to DNA double-strand break repair sites requires complex formation with S100A11 | journal = Molecular Biology of the Cell | volume = 19 | issue = 7 | pages = 2926-35 | date = July 2008 | pmid = 18463164 | doi = 10.1091/mbc.e07-11-1167 }}</ref>  These finding suggest a potential role of S100A11 in the process of [[homologous recombination]] repair of [[double-strand breaks]].<ref>{{cite journal | vauthors = Foertsch F, Szambowska A, Weise A, Zielinski A, Schlott B, Kraft F, Mrasek K, Borgmann K, Pospiech H, Grosse F, Melle C | title = S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci | journal = Cell Cycle | volume = 15 | issue = 20 | pages = 2766-79 | date = October 2016 | pmid = 27590262 | pmc = 5053559 | doi = 10.1080/15384101.2016.1220457 }}</ref>
 
== Interactions ==
S100A11 has been shown to [[Protein-protein interaction|interact]] with [[Nucleolin]]<ref name=pmid14623863>{{cite journal | vauthors = Sakaguchi M, Miyazaki M, Takaishi M, Sakaguchi Y, Makino E, Kataoka N, Yamada H, Namba M, Huh NH | title = S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes | journal = The Journal of Cell Biology | volume = 163 | issue = 4 | pages = 825–35 | date = November 2003 | pmid = 14623863 | pmc = 2173690 | doi = 10.1083/jcb.200304017 }}</ref>, [[S100B]]<ref name="pmid10913138">{{cite journal | vauthors = Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J | title = S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo | journal = The Journal of Biological Chemistry | volume = 275 | issue = 45 | pages = 35302–10 | date = November 2000 | pmid = 10913138 | doi = 10.1074/jbc.M003943200 }}</ref> and [[RAD54B]].<ref>{{cite journal | vauthors = Murzik U, Hemmerich P, Weidtkamp-Peters S, Ulbricht T, Bussen W, Hentschel J, von Eggeling F, Melle C | title = Rad54B targeting to DNA double-strand break repair sites requires complex formation with S100A11 | journal = Molecular Biology of the Cell | volume = 19 | issue = 7 | pages = 2926-35 | date = July 2008 | pmid = 18463164 | doi = 10.1091/mbc.e07-11-1167 }}</ref>
 
 
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J | title = Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes | journal = Electrophoresis | volume = 13 | issue = 12 | pages = 960–9 | date = December 1992 | pmid = 1286667 | doi = 10.1002/elps.11501301199 }}
| citations =
* {{cite journal | vauthors = Tomasetto C, Régnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC | title = Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17 | journal = Genomics | volume = 28 | issue = 3 | pages = 367–76 | date = August 1995 | pmid = 7490069 | doi = 10.1006/geno.1995.1163 }}
*{{cite journal | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi= }}
* {{cite journal | vauthors = Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW | title = Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family | journal = Genomics | volume = 25 | issue = 3 | pages = 638–43 | date = February 1995 | pmid = 7759097 | doi = 10.1016/0888-7543(95)80005-7 }}
*{{cite journal | author=Tomasetto C, Régnier C, Moog-Lutz C, ''et al.'' |title=Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |journal=Genomics |volume=28 |issue= 3 |pages= 367-76 |year= 1996 |pmid= 7490069 |doi= 10.1006/geno.1995.1163 }}
* {{cite journal | vauthors = Tanaka M, Adzuma K, Iwami M, Yoshimoto K, Monden Y, Itakura M | title = Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis | journal = Cancer Letters | volume = 89 | issue = 2 | pages = 195–200 | date = March 1995 | pmid = 7889529 | doi = 10.1016/0304-3835(94)03687-E }}
*{{cite journal | author=Schäfer BW, Wicki R, Engelkamp D, ''et al.'' |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638-43 |year= 1995 |pmid= 7759097 |doi= }}
* {{cite journal | vauthors = Mailliard WS, Haigler HT, Schlaepfer DD | title = Calcium-dependent binding of S100C to the N-terminal domain of annexin I | journal = The Journal of Biological Chemistry | volume = 271 | issue = 2 | pages = 719–25 | date = January 1996 | pmid = 8557678 | doi = 10.1074/jbc.271.2.719 }}
*{{cite journal | author=Tanaka M, Adzuma K, Iwami M, ''et al.'' |title=Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. |journal=Cancer Lett. |volume=89 |issue= 2 |pages= 195-200 |year= 1995 |pmid= 7889529 |doi= }}
* {{cite journal | vauthors = Seemann J, Weber K, Gerke V | title = Annexin I targets S100C to early endosomes | journal = FEBS Letters | volume = 413 | issue = 1 | pages = 185–90 | date = August 1997 | pmid = 9287141 | doi = 10.1016/S0014-5793(97)00911-3 }}
*{{cite journal | author=Mailliard WS, Haigler HT, Schlaepfer DD |title=Calcium-dependent binding of S100C to the N-terminal domain of annexin I. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 719-25 |year= 1996 |pmid= 8557678 |doi= }}
* {{cite journal | vauthors = Inada H, Naka M, Tanaka T, Davey GE, Heizmann CW | title = Human S100A11 exhibits differential steady-state RNA levels in various tissues and a distinct subcellular localization | journal = Biochemical and Biophysical Research Communications | volume = 263 | issue = 1 | pages = 135–8 | date = September 1999 | pmid = 10486266 | doi = 10.1006/bbrc.1999.1319 }}
*{{cite journal | author=Wicki R, Marenholz I, Mischke D, ''et al.'' |title=Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. |journal=Cell Calcium |volume=20 |issue= 6 |pages= 459-64 |year= 1997 |pmid= 8985590 |doi= }}
* {{cite journal | vauthors = Réty S, Osterloh D, Arié JP, Tabaries S, Seeman J, Russo-Marie F, Gerke V, Lewit-Bentley A | title = Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I | journal = Structure | volume = 8 | issue = 2 | pages = 175–84 | date = February 2000 | pmid = 10673436 | doi = 10.1016/S0969-2126(00)00093-9 }}
*{{cite journal | author=Seemann J, Weber K, Gerke V |title=Annexin I targets S100C to early endosomes. |journal=FEBS Lett. |volume=413 |issue= 1 |pages= 185-90 |year= 1997 |pmid= 9287141 |doi= }}
* {{cite journal | vauthors = Sakaguchi M, Miyazaki M, Inoue Y, Tsuji T, Kouchi H, Tanaka T, Yamada H, Namba M | title = Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts | journal = The Journal of Cell Biology | volume = 149 | issue = 6 | pages = 1193–206 | date = June 2000 | pmid = 10851017 | doi = 10.1083/jcb.149.6.1193 }}
*{{cite journal | author=Inada H, Naka M, Tanaka T, ''et al.'' |title=Human S100A11 exhibits differential steady-state RNA levels in various tissues and a distinct subcellular localization. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 1 |pages= 135-8 |year= 1999 |pmid= 10486266 |doi= 10.1006/bbrc.1999.1319 }}
* {{cite journal | vauthors = Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J | title = S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo | journal = The Journal of Biological Chemistry | volume = 275 | issue = 45 | pages = 35302–10 | date = November 2000 | pmid = 10913138 | doi = 10.1074/jbc.M003943200 }}
*{{cite journal | author=Réty S, Osterloh D, Arié JP, ''et al.'' |title=Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I. |journal=Structure |volume=8 |issue= 2 |pages= 175-84 |year= 2000 |pmid= 10673436 |doi= }}
* {{cite journal | vauthors = Ruse M, Lambert A, Robinson N, Ryan D, Shon KJ, Eckert RL | title = S100A7, S100A10, and S100A11 are transglutaminase substrates | journal = Biochemistry | volume = 40 | issue = 10 | pages = 3167–73 | date = March 2001 | pmid = 11258932 | doi = 10.1021/bi0019747 }}
*{{cite journal | author=Sakaguchi M, Miyazaki M, Inoue Y, ''et al.'' |title=Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts. |journal=J. Cell Biol. |volume=149 |issue= 6 |pages= 1193-206 |year= 2000 |pmid= 10851017 |doi= }}
* {{cite journal | vauthors = Kondo A, Sakaguchi M, Makino E, Namba M, Okada S, Huh NH | title = Localization of S100C immunoreactivity in various human tissues | journal = Acta Medica Okayama | volume = 56 | issue = 1 | pages = 31–4 | date = February 2002 | pmid = 11873942 | url = http://www.lib.okayama-u.ac.jp/www/acta/pdf/56_1_31.pdf }}
*{{cite journal | author=Deloulme JC, Assard N, Mbele GO, ''et al.'' |title=S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35302-10 |year= 2001 |pmid= 10913138 |doi= 10.1074/jbc.M003943200 }}
* {{cite journal | vauthors = Bianchi R, Giambanco I, Arcuri C, Donato R | title = Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments | journal = Microscopy Research and Technique | volume = 60 | issue = 6 | pages = 639–51 | date = April 2003 | pmid = 12645011 | doi = 10.1002/jemt.10305 }}
*{{cite journal | author=Ruse M, Lambert A, Robinson N, ''et al.'' |title=S100A7, S100A10, and S100A11 are transglutaminase substrates. |journal=Biochemistry |volume=40 |issue= 10 |pages= 3167-73 |year= 2001 |pmid= 11258932 |doi= }}
* {{cite journal | vauthors = Broome AM, Ryan D, Eckert RL | title = S100 protein subcellular localization during epidermal differentiation and psoriasis | journal = The Journal of Histochemistry and Cytochemistry | volume = 51 | issue = 5 | pages = 675–85 | date = May 2003 | pmid = 12704215 | pmc = 3785113 | doi = 10.1177/002215540305100513 }}
*{{cite journal | author=Kondo A, Sakaguchi M, Makino E, ''et al.'' |title=Localization of S100C immunoreactivity in various human tissues. |journal=Acta Med. Okayama |volume=56 |issue= 1 |pages= 31-4 |year= 2002 |pmid= 11873942 |doi= }}
* {{cite journal | vauthors = Sakaguchi M, Miyazaki M, Takaishi M, Sakaguchi Y, Makino E, Kataoka N, Yamada H, Namba M, Huh NH | title = S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes | journal = The Journal of Cell Biology | volume = 163 | issue = 4 | pages = 825–35 | date = November 2003 | pmid = 14623863 | doi = 10.1083/jcb.200304017 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Broome AM, Eckert RL | title = Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor | journal = The Journal of Investigative Dermatology | volume = 122 | issue = 1 | pages = 29–38 | date = January 2004 | pmid = 14962086 | doi = 10.1046/j.0022-202X.2003.22105.x }}
*{{cite journal | author=Bianchi R, Giambanco I, Arcuri C, Donato R |title=Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments. |journal=Microsc. Res. Tech. |volume=60 |issue= 6 |pages= 639-51 |year= 2003 |pmid= 12645011 |doi= 10.1002/jemt.10305 }}
* {{cite journal | vauthors = Sakaguchi M, Miyazaki M, Sonegawa H, Kashiwagi M, Ohba M, Kuroki T, Namba M, Huh NH | title = PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11 | journal = The Journal of Cell Biology | volume = 164 | issue = 7 | pages = 979–84 | date = March 2004 | pmid = 15051732 | doi = 10.1083/jcb.200312041 }}
*{{cite journal | author=Broome AM, Ryan D, Eckert RL |title=S100 protein subcellular localization during epidermal differentiation and psoriasis. |journal=J. Histochem. Cytochem. |volume=51 |issue= 5 |pages= 675-85 |year= 2003 |pmid= 12704215 |doi= }}
* {{cite journal | vauthors = Mori M, Shimada H, Gunji Y, Matsubara H, Hayashi H, Nimura Y, Kato M, Takiguchi M, Ochiai T, Seki N | title = S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer | journal = Oncology Reports | volume = 11 | issue = 6 | pages = 1287–93 | date = June 2004 | pmid = 15138568 | doi = 10.3892/or.11.6.1287 }}
*{{cite journal | author=Sakaguchi M, Miyazaki M, Takaishi M, ''et al.'' |title=S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes. |journal=J. Cell Biol. |volume=163 |issue= 4 |pages= 825-35 |year= 2004 |pmid= 14623863 |doi= 10.1083/jcb.200304017 }}
*{{cite journal | author=Broome AM, Eckert RL |title=Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. |journal=J. Invest. Dermatol. |volume=122 |issue= 1 |pages= 29-38 |year= 2004 |pmid= 14962086 |doi= 10.1046/j.0022-202X.2003.22105.x }}
*{{cite journal  | author=Sakaguchi M, Miyazaki M, Sonegawa H, ''et al.'' |title=PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11. |journal=J. Cell Biol. |volume=164 |issue= 7 |pages= 979-84 |year= 2004 |pmid= 15051732 |doi= 10.1083/jcb.200312041 }}
*{{cite journal  | author=Mori M, Shimada H, Gunji Y, ''et al.'' |title=S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer. |journal=Oncol. Rep. |volume=11 |issue= 6 |pages= 1287-93 |year= 2004 |pmid= 15138568 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:S100 proteins]]
{{WikiDoc Sources}}

Revision as of 01:52, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene.[1][2]

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.[3] S100A11 is localized in the cytoplasm of resting human keratinocytes in vitro.[4]

S100A11, along with all 13 members of the S100 family, are located as a cluster on chromosome 1q21. The protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.[2]

Suppression of S100A11 by small interfering RNA caused cells to apoptosis, and overexpression of S100A11 has been found to inhibit apoptosis in tumor cells.[5] Furthermore, the knock-down of S100A11 via siRNA reduces the sister-chromatid exchange and the viability of cells.

IL-8 and TNF-alpha induce S100A11 expression and release in chondrocytes in culture and exogenous S100A11 causes chondrocyte hypertrophy.[6]

It has been shown that S100A11 enhances the recombination activity of human RAD51 in vitro. A knock-down leads to diffuse distribution of RAD54B.[7] These finding suggest a potential role of S100A11 in the process of homologous recombination repair of double-strand breaks.[8]

Interactions

S100A11 has been shown to interact with Nucleolin[9], S100B[10] and RAD54B.[11]


References

  1. ↑ Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.
  2. ↑ 2.0 2.1 "Entrez Gene: S100A11 S100 calcium binding protein A11".
  3. ↑ He H, Li J, Weng S, Li M, Yu Y (2009). "S100A11: diverse function and pathology corresponding to different target proteins". Cell Biochemistry and Biophysics. 55 (3): 117–26. doi:10.1007/s12013-009-9061-8. PMID 19649745.
  4. ↑ Sakaguchi M, Huh NH (October 2011). "S100A11, a dual growth regulator of epidermal keratinocytes". Amino Acids. 41 (4): 797–807. doi:10.1007/s00726-010-0747-4. PMID 20872027.
  5. ↑ Kanamori T, Takakura K, Mandai M, Kariya M, Fukuhara K, Sakaguchi M, Huh NH, Saito K, Sakurai T, Fujita J, Fujii S (October 2004). "Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours". Molecular Human Reproduction. 10 (10): 735–42. doi:10.1093/molehr/gah100. PMID 15322223.
  6. ↑ Cecil DL, Johnson K, Rediske J, Lotz M, Schmidt AM, Terkeltaub R (December 2005). "Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products". Journal of Immunology. 175 (12): 8296–302. doi:10.4049/jimmunol.175.12.8296. PMID 16339570.
  7. ↑ Murzik U, Hemmerich P, Weidtkamp-Peters S, Ulbricht T, Bussen W, Hentschel J, von Eggeling F, Melle C (July 2008). "Rad54B targeting to DNA double-strand break repair sites requires complex formation with S100A11". Molecular Biology of the Cell. 19 (7): 2926–35. doi:10.1091/mbc.e07-11-1167. PMID 18463164.
  8. ↑ Foertsch F, Szambowska A, Weise A, Zielinski A, Schlott B, Kraft F, Mrasek K, Borgmann K, Pospiech H, Grosse F, Melle C (October 2016). "S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci". Cell Cycle. 15 (20): 2766–79. doi:10.1080/15384101.2016.1220457. PMC 5053559. PMID 27590262.
  9. ↑ Sakaguchi M, Miyazaki M, Takaishi M, Sakaguchi Y, Makino E, Kataoka N, Yamada H, Namba M, Huh NH (November 2003). "S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes". The Journal of Cell Biology. 163 (4): 825–35. doi:10.1083/jcb.200304017. PMC 2173690. PMID 14623863.
  10. ↑ Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J (November 2000). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". The Journal of Biological Chemistry. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138.
  11. ↑ Murzik U, Hemmerich P, Weidtkamp-Peters S, Ulbricht T, Bussen W, Hentschel J, von Eggeling F, Melle C (July 2008). "Rad54B targeting to DNA double-strand break repair sites requires complex formation with S100A11". Molecular Biology of the Cell. 19 (7): 2926–35. doi:10.1091/mbc.e07-11-1167. PMID 18463164.

Further reading

  • Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
  • Tomasetto C, Régnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (August 1995). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
  • Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (February 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
  • Tanaka M, Adzuma K, Iwami M, Yoshimoto K, Monden Y, Itakura M (March 1995). "Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis". Cancer Letters. 89 (2): 195–200. doi:10.1016/0304-3835(94)03687-E. PMID 7889529.
  • Mailliard WS, Haigler HT, Schlaepfer DD (January 1996). "Calcium-dependent binding of S100C to the N-terminal domain of annexin I". The Journal of Biological Chemistry. 271 (2): 719–25. doi:10.1074/jbc.271.2.719. PMID 8557678.
  • Seemann J, Weber K, Gerke V (August 1997). "Annexin I targets S100C to early endosomes". FEBS Letters. 413 (1): 185–90. doi:10.1016/S0014-5793(97)00911-3. PMID 9287141.
  • Inada H, Naka M, Tanaka T, Davey GE, Heizmann CW (September 1999). "Human S100A11 exhibits differential steady-state RNA levels in various tissues and a distinct subcellular localization". Biochemical and Biophysical Research Communications. 263 (1): 135–8. doi:10.1006/bbrc.1999.1319. PMID 10486266.
  • Réty S, Osterloh D, Arié JP, Tabaries S, Seeman J, Russo-Marie F, Gerke V, Lewit-Bentley A (February 2000). "Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I". Structure. 8 (2): 175–84. doi:10.1016/S0969-2126(00)00093-9. PMID 10673436.
  • Sakaguchi M, Miyazaki M, Inoue Y, Tsuji T, Kouchi H, Tanaka T, Yamada H, Namba M (June 2000). "Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts". The Journal of Cell Biology. 149 (6): 1193–206. doi:10.1083/jcb.149.6.1193. PMID 10851017.
  • Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J (November 2000). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". The Journal of Biological Chemistry. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138.
  • Ruse M, Lambert A, Robinson N, Ryan D, Shon KJ, Eckert RL (March 2001). "S100A7, S100A10, and S100A11 are transglutaminase substrates". Biochemistry. 40 (10): 3167–73. doi:10.1021/bi0019747. PMID 11258932.
  • Kondo A, Sakaguchi M, Makino E, Namba M, Okada S, Huh NH (February 2002). "Localization of S100C immunoreactivity in various human tissues" (PDF). Acta Medica Okayama. 56 (1): 31–4. PMID 11873942.
  • Bianchi R, Giambanco I, Arcuri C, Donato R (April 2003). "Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments". Microscopy Research and Technique. 60 (6): 639–51. doi:10.1002/jemt.10305. PMID 12645011.
  • Broome AM, Ryan D, Eckert RL (May 2003). "S100 protein subcellular localization during epidermal differentiation and psoriasis". The Journal of Histochemistry and Cytochemistry. 51 (5): 675–85. doi:10.1177/002215540305100513. PMC 3785113. PMID 12704215.
  • Sakaguchi M, Miyazaki M, Takaishi M, Sakaguchi Y, Makino E, Kataoka N, Yamada H, Namba M, Huh NH (November 2003). "S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes". The Journal of Cell Biology. 163 (4): 825–35. doi:10.1083/jcb.200304017. PMID 14623863.
  • Broome AM, Eckert RL (January 2004). "Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor". The Journal of Investigative Dermatology. 122 (1): 29–38. doi:10.1046/j.0022-202X.2003.22105.x. PMID 14962086.
  • Sakaguchi M, Miyazaki M, Sonegawa H, Kashiwagi M, Ohba M, Kuroki T, Namba M, Huh NH (March 2004). "PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11". The Journal of Cell Biology. 164 (7): 979–84. doi:10.1083/jcb.200312041. PMID 15051732.
  • Mori M, Shimada H, Gunji Y, Matsubara H, Hayashi H, Nimura Y, Kato M, Takiguchi M, Ochiai T, Seki N (June 2004). "S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer". Oncology Reports. 11 (6): 1287–93. doi:10.3892/or.11.6.1287. PMID 15138568.
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