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{{Infobox_gene}}
{{PBB_Controls
'''FAS-associated factor 1''' is a [[protein]] that in humans is encoded by the ''FAF1'' [[gene]].<ref name="pmid10462485">{{cite journal | vauthors = Ryu SW, Chae SK, Lee KJ, Kim E | title = Identification and characterization of human Fas associated factor 1, hFAF1 | journal = Biochem Biophys Res Commun | volume = 262 | issue = 2 | pages = 388–94 |date=Oct 1999 | pmid = 10462485 | pmc =  | doi = 10.1006/bbrc.1999.1217 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FAF1 Fas (TNFRSF6) associated factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11124| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FAF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h8c.
| PDB = {{PDB2|1h8c}}
| Name = Fas (TNFRSF6) associated factor 1
| HGNCid = 3578
| Symbol = FAF1
| AltSymbols =; CGI-03; FLJ37524; HFAF1s; hFAF1
| OMIM = 604460
| ECnumber =
| Homologene = 5120
| MGIid = 109419
  | GeneAtlas_image1 = PBB_GE_FAF1_218080_x_at_tn.png
| Function = {{GNF_GO|id=GO:0008605 |text = protein kinase CK2 regulator activity}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0030191 |text = Hsp70/Hsc70 protein inhibitor activity}} {{GNF_GO|id=GO:0031072 |text = heat shock protein binding}} {{GNF_GO|id=GO:0051059 |text = NF-kappaB binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0031265 |text = CD95 death-inducing signaling complex}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007253 |text = cytoplasmic sequestering of NF-kappaB}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0031334 |text = positive regulation of protein complex assembly}} {{GNF_GO|id=GO:0042176 |text = regulation of protein catabolic process}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0043161 |text = proteasomal ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11124
    | Hs_Ensembl = ENSG00000185104
    | Hs_RefseqProtein = NP_572051
    | Hs_RefseqmRNA = NM_131917
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 50677738
    | Hs_GenLoc_end = 51198524
    | Hs_Uniprot = Q9UNN5
    | Mm_EntrezGene = 14084
    | Mm_Ensembl = ENSMUSG00000010517
    | Mm_RefseqmRNA = NM_007983
    | Mm_RefseqProtein = NP_032009
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 109174520
    | Mm_GenLoc_end = 109461892
    | Mm_Uniprot = Q6P1F8
  }}
}}
'''Fas (TNFRSF6) associated factor 1''', also known as '''FAF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FAF1 Fas (TNFRSF6) associated factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11124| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.<ref name="entrez">{{cite web | title = Entrez Gene: FAF1 Fas (TNFRSF6) associated factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11124| accessdate = }}</ref>
| summary_text = Interaction of [[Fas ligand]] (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called [[apoptosis]], in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a [[ubiquitin]]-like domain but not the FAS-binding domain.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chu K, Niu X, Williams LT |title=A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11894-8 |year= 1996 |pmid= 8524870 |doi=  }}
*{{cite journal  | vauthors=Chu K, Niu X, Williams LT |title=A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11894–8 |year= 1996 |pmid= 8524870 |doi=10.1073/pnas.92.25.11894  | pmc=40509 }}
*{{cite journal  | author=Juo P, Kuo CJ, Yuan J, Blenis J |title=Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. |journal=Curr. Biol. |volume=8 |issue= 18 |pages= 1001-8 |year= 1998 |pmid= 9740801 |doi= }}
*{{cite journal  | vauthors=Juo P, Kuo CJ, Yuan J, Blenis J |title=Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. |journal=Curr. Biol. |volume=8 |issue= 18 |pages= 1001–8 |year= 1998 |pmid= 9740801 |doi=10.1016/S0960-9822(07)00420-4  }}
*{{cite journal  | author=Kusk M, Ahmed R, Thomsen B, ''et al.'' |title=Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins. |journal=Mol. Cell. Biochem. |volume=191 |issue= 1-2 |pages= 51-8 |year= 1999 |pmid= 10094392 |doi=  }}
*{{cite journal  | vauthors=Kusk M, Ahmed R, Thomsen B |title=Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins. |journal=Mol. Cell. Biochem. |volume=191 |issue= 1-2 |pages= 51–8 |year= 1999 |pmid= 10094392 |doi=10.1023/A:1006840613986 |display-authors=etal}}
*{{cite journal  | author=Ryu SW, Chae SK, Lee KJ, Kim E |title=Identification and characterization of human Fas associated factor 1, hFAF1. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 2 |pages= 388-94 |year= 1999 |pmid= 10462485 |doi= 10.1006/bbrc.1999.1217 }}
*{{cite journal  | vauthors=Lai CH, Chou CY, Ch'ang LY |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703  | pmc=310876  |display-authors=etal}}
*{{cite journal  | author=Lai CH, Chou CY, Ch'ang LY, ''et al.'' |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703-13 |year= 2000 |pmid= 10810093 |doi= }}
*{{cite journal  | vauthors=Buchberger A, Howard MJ, Proctor M, Bycroft M |title=The UBX domain: a widespread ubiquitin-like module. |journal=J. Mol. Biol. |volume=307 |issue= 1 |pages= 17–24 |year= 2001 |pmid= 11243799 |doi= 10.1006/jmbi.2000.4462 }}
*{{cite journal  | author=Buchberger A, Howard MJ, Proctor M, Bycroft M |title=The UBX domain: a widespread ubiquitin-like module. |journal=J. Mol. Biol. |volume=307 |issue= 1 |pages= 17-24 |year= 2001 |pmid= 11243799 |doi= 10.1006/jmbi.2000.4462 }}
*{{cite journal  | vauthors=Jensen HH, Hjerrild M, Guerra B |title=Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 6 |pages= 577–89 |year= 2001 |pmid= 11378439 |doi=10.1016/S1357-2725(01)00039-5  |display-authors=etal}}
*{{cite journal  | author=Jensen HH, Hjerrild M, Guerra B, ''et al.'' |title=Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 6 |pages= 577-89 |year= 2001 |pmid= 11378439 |doi= }}
*{{cite journal  | vauthors=Ryu SW, Kim E |title=Apoptosis induced by human Fas-associated factor 1, hFAF1, requires its ubiquitin homologous domain, but not the Fas-binding domain. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1027–32 |year= 2001 |pmid= 11527403 |doi= 10.1006/bbrc.2001.5505 }}
*{{cite journal  | author=Ryu SW, Kim E |title=Apoptosis induced by human Fas-associated factor 1, hFAF1, requires its ubiquitin homologous domain, but not the Fas-binding domain. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1027-32 |year= 2001 |pmid= 11527403 |doi= 10.1006/bbrc.2001.5505 }}
*{{cite journal  | vauthors=Guerra B, Boldyreff B, Issinger OG |title=FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. |journal=Int. J. Oncol. |volume=19 |issue= 6 |pages= 1117–26 |year= 2002 |pmid= 11713579 |doi= 10.3892/ijo.19.6.1117}}
*{{cite journal  | author=Guerra B, Boldyreff B, Issinger OG |title=FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. |journal=Int. J. Oncol. |volume=19 |issue= 6 |pages= 1117-26 |year= 2002 |pmid= 11713579 |doi=  }}
*{{cite journal  | vauthors=De Haro L, Janknecht R |title=Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. |journal=Nucleic Acids Res. |volume=30 |issue= 13 |pages= 2972–9 |year= 2002 |pmid= 12087183 |doi=10.1093/nar/gkf390  | pmc=117045 }}
*{{cite journal  | author=De Haro L, Janknecht R |title=Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. |journal=Nucleic Acids Res. |volume=30 |issue= 13 |pages= 2972-9 |year= 2002 |pmid= 12087183 |doi=  }}
*{{cite journal  | vauthors=Imai Y, Nakada A, Hashida R |title=Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 5 |pages= 1282–90 |year= 2002 |pmid= 12372427 |doi=10.1016/S0006-291X(02)02380-X |display-authors=etal}}
*{{cite journal  | author=Imai Y, Nakada A, Hashida R, ''et al.'' |title=Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 5 |pages= 1282-90 |year= 2002 |pmid= 12372427 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ryu SW, Lee SJ, Park MY |title=Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 24003–10 |year= 2003 |pmid= 12702723 |doi= 10.1074/jbc.M302200200 |display-authors=etal}}
*{{cite journal  | author=Ryu SW, Lee SJ, Park MY, ''et al.'' |title=Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 24003-10 |year= 2003 |pmid= 12702723 |doi= 10.1074/jbc.M302200200 }}
*{{cite journal  | vauthors=Olsen BB, Jessen V, Højrup P |title=Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus. |journal=FEBS Lett. |volume=546 |issue= 2-3 |pages= 218–22 |year= 2003 |pmid= 12832043 |doi=10.1016/S0014-5793(03)00575-1  |display-authors=etal}}
*{{cite journal  | author=Olsen BB, Jessen V, Højrup P, ''et al.'' |title=Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus. |journal=FEBS Lett. |volume=546 |issue= 2-3 |pages= 218-22 |year= 2003 |pmid= 12832043 |doi=  }}
*{{cite journal  | vauthors=Bjørling-Poulsen M, Seitz G, Guerra B, Issinger OG |title=The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas. |journal=Int. J. Oncol. |volume=23 |issue= 4 |pages= 1015–23 |year= 2004 |pmid= 12963981 |doi=  10.3892/ijo.23.4.1015}}
*{{cite journal  | author=Bjørling-Poulsen M, Seitz G, Guerra B, Issinger OG |title=The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas. |journal=Int. J. Oncol. |volume=23 |issue= 4 |pages= 1015-23 |year= 2004 |pmid= 12963981 |doi= }}
*{{cite journal  | vauthors=Park MY, Jang HD, Lee SY |title=Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. |journal=J. Biol. Chem. |volume=279 |issue= 4 |pages= 2544–9 |year= 2004 |pmid= 14600157 |doi= 10.1074/jbc.M304565200 |display-authors=etal}}
*{{cite journal  | author=Park MY, Jang HD, Lee SY, ''et al.'' |title=Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. |journal=J. Biol. Chem. |volume=279 |issue= 4 |pages= 2544-9 |year= 2004 |pmid= 14600157 |doi= 10.1074/jbc.M304565200 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Stoletov KV, Terman BI |title=Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 1 |pages= 70–5 |year= 2004 |pmid= 15207703 |doi= 10.1016/j.bbrc.2004.05.134 }}
*{{cite journal  | author=Stoletov KV, Terman BI |title=Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 1 |pages= 70-5 |year= 2004 |pmid= 15207703 |doi= 10.1016/j.bbrc.2004.05.134 }}
*{{cite journal  | vauthors=Colland F, Jacq X, Trouplin V |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 |display-authors=etal}}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=11124}}
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Latest revision as of 04:31, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.[1][2]

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.[2]

References

  1. ↑ Ryu SW, Chae SK, Lee KJ, Kim E (Oct 1999). "Identification and characterization of human Fas associated factor 1, hFAF1". Biochem Biophys Res Commun. 262 (2): 388–94. doi:10.1006/bbrc.1999.1217. PMID 10462485.
  2. ↑ 2.0 2.1 "Entrez Gene: FAF1 Fas (TNFRSF6) associated factor 1".

Further reading



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