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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Claspin''' is a [[protein]] that in humans is encoded by the ''CLSPN'' [[gene]].<ref name="pmid11090622">{{cite journal | vauthors = Kumagai A, Dunphy WG | title = Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts | journal = Mol Cell | volume = 6 | issue = 4 | pages = 839–49 |date=Nov 2000 | pmid = 11090622 | pmc =  | doi =10.1016/S1097-2765(05)00092-4  }}</ref><ref name="pmid12766152">{{cite journal | vauthors = Chini CC, Chen J | title = Human claspin is required for replication checkpoint control | journal = J Biol Chem | volume = 278 | issue = 32 | pages = 30057–62 |date=Aug 2003 | pmid = 12766152 | pmc = | doi = 10.1074/jbc.M301136200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLSPN claspin homolog (Xenopus laevis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63967| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Claspin homolog (Xenopus laevis)
| HGNCid = 19715
| Symbol = CLSPN
| AltSymbols =; CLASPIN; MGC131612; MGC131613; MGC131615
| OMIM = 605434
| ECnumber = 
| Homologene = 11138
| MGIid = 2445153
| GeneAtlas_image1 = PBB_GE_CLSPN_219621_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 63967
    | Hs_Ensembl = ENSG00000092853
    | Hs_RefseqProtein = NP_071394
    | Hs_RefseqmRNA = NM_022111
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 35958406
    | Hs_GenLoc_end = 36008155
    | Hs_Uniprot = Q9HAW4
    | Mm_EntrezGene = 269582
    | Mm_Ensembl = ENSMUSG00000042489
    | Mm_RefseqmRNA = NM_175554
    | Mm_RefseqProtein = NP_780763
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 126059239
    | Mm_GenLoc_end = 126096207
    | Mm_Uniprot = Q3TSV3
  }}
}}
'''Claspin homolog (Xenopus laevis)''', also known as '''CLSPN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLSPN claspin homolog (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63967| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
''[[Xenopus]]'' claspin is an essential upstream regulator of [[CHEK1|checkpoint kinase 1]] and triggers a checkpoint arrest of the [[cell cycle]] in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
==Interactions==
| summary_text = Xenopus claspin is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CLSPN claspin homolog (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63967| accessdate = }}</ref>
CLSPN has been shown to [[Protein-protein interaction|interact]] with:
}}
{{div col|colwidth=20em}}
* [[BRCA1]],<ref name = "pmid15096610">{{cite journal | vauthors = Lin SY, Li K, Stewart GS, Elledge SJ | title = Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 17 | pages = 6484–9 | year = 2004 | pmid = 15096610 | pmc = 404071 | doi = 10.1073/pnas.0401847101 }}</ref>
* [[CDC45-related protein|CDC45]],<ref name="pmid21478680">{{cite journal | vauthors = Serçin O, Kemp MG | title = Characterization of functional domains in human Claspin | journal = Cell Cycle | volume = 10 | issue = 10 | pages = 1599–606 |date=May 2011 | pmid = 21478680 | pmc = 3127160 | doi =  10.4161/cc.10.10.15562}}</ref>
* [[CHEK1]],<ref name = pmid12766152 />
* [[POLE (enzyme)|POLE]],<ref name="pmid21478680"/>
* [[RAD17]],<ref name="pmid21478680"/> and
* [[USP7]].<ref name = pmid19124652>{{cite journal | vauthors = Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N | title = USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin | journal = J. Cell Biol. | volume = 184 | issue = 1 | pages = 13–9 | year = 2009 | pmid = 19124652 | pmc = 2615094 | doi = 10.1083/jcb.200807137 }}</ref>  
{{Div col end}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CLSPN}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Chini CC, Chen J |title=Claspin, a regulator of Chk1 in DNA replication stress pathway. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 1033–7 |year= 2005 |pmid= 15279790 |doi= 10.1016/j.dnarep.2004.03.001 }}
| citations =
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Chini CC, Chen J |title=Claspin, a regulator of Chk1 in DNA replication stress pathway. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 1033-7 |year= 2005 |pmid= 15279790 |doi= 10.1016/j.dnarep.2004.03.001 }}
*{{cite journal  | vauthors=Lin SY, Li K, Stewart GS, Elledge SJ |title=Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 17 |pages= 6484–9 |year= 2004 |pmid= 15096610 |doi= 10.1073/pnas.0401847101  | pmc=404071 }}
*{{cite journal  | author=Kumagai A, Dunphy WG |title=Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. |journal=Mol. Cell |volume=6 |issue= 4 |pages= 839-49 |year= 2000 |pmid= 11090622 |doi=  }}
*{{cite journal  | vauthors=Sørensen CS, Syljuåsen RG, Lukas J, Bartek J |title=ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. |journal=Cell Cycle |volume=3 |issue= 7 |pages= 941–5 |year= 2006 |pmid= 15190204 |doi= 10.4161/cc.3.7.972}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Sar F, Lindsey-Boltz LA, Subramanian D |title=Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39289–95 |year= 2004 |pmid= 15226314 |doi= 10.1074/jbc.M405793200 |display-authors=etal}}
*{{cite journal  | author=Chini CC, Chen J |title=Human claspin is required for replication checkpoint control. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30057-62 |year= 2003 |pmid= 12766152 |doi= 10.1074/jbc.M301136200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Lin SY, Li K, Stewart GS, Elledge SJ |title=Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 17 |pages= 6484-9 |year= 2004 |pmid= 15096610 |doi= 10.1073/pnas.0401847101 }}
*{{cite journal  | vauthors=Clarke CA, Clarke PR |title=DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 705–12 |year= 2005 |pmid= 15707391 |doi= 10.1042/BJ20041966  | pmc=1138979 }}
*{{cite journal  | author=Sørensen CS, Syljuåsen RG, Lukas J, Bartek J |title=ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. |journal=Cell Cycle |volume=3 |issue= 7 |pages= 941-5 |year= 2006 |pmid= 15190204 |doi=  }}
*{{cite journal  | vauthors=Clarke CA, Bennett LN, Clarke PR |title=Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. |journal=J. Biol. Chem. |volume=280 |issue= 42 |pages= 35337–45 |year= 2005 |pmid= 16123041 |doi= 10.1074/jbc.M506460200 }}
*{{cite journal  | author=Sar F, Lindsey-Boltz LA, Subramanian D, ''et al.'' |title=Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39289-95 |year= 2004 |pmid= 15226314 |doi= 10.1074/jbc.M405793200 }}
*{{cite journal  | vauthors=Chini CC, Wood J, Chen J |title=Chk1 is required to maintain claspin stability. |journal=Oncogene |volume=25 |issue= 30 |pages= 4165–71 |year= 2006 |pmid= 16501606 |doi= 10.1038/sj.onc.1209447 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
*{{cite journal  | author=Clarke CA, Clarke PR |title=DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 705-12 |year= 2005 |pmid= 15707391 |doi= 10.1042/BJ20041966 }}
*{{cite journal  | vauthors=Bennett LN, Clarke PR |title=Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation. |journal=FEBS Lett. |volume=580 |issue= 17 |pages= 4176–81 |year= 2006 |pmid= 16828751 |doi= 10.1016/j.febslet.2006.06.071 }}
*{{cite journal  | author=Clarke CA, Bennett LN, Clarke PR |title=Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. |journal=J. Biol. Chem. |volume=280 |issue= 42 |pages= 35337-45 |year= 2005 |pmid= 16123041 |doi= 10.1074/jbc.M506460200 }}
*{{cite journal  | vauthors=Liu S, Bekker-Jensen S, Mailand N |title=Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. |journal=Mol. Cell. Biol. |volume=26 |issue= 16 |pages= 6056–64 |year= 2006 |pmid= 16880517 |doi= 10.1128/MCB.00492-06  | pmc=1592810 |display-authors=etal}}
*{{cite journal  | author=Chini CC, Wood J, Chen J |title=Chk1 is required to maintain claspin stability. |journal=Oncogene |volume=25 |issue= 30 |pages= 4165-71 |year= 2006 |pmid= 16501606 |doi= 10.1038/sj.onc.1209447 }}
*{{cite journal  | vauthors=Mailand N, Bekker-Jensen S, Bartek J, Lukas J |title=Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. |journal=Mol. Cell |volume=23 |issue= 3 |pages= 307–18 |year= 2006 |pmid= 16885021 |doi= 10.1016/j.molcel.2006.06.016 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | vauthors=Peschiaroli A, Dorrello NV, Guardavaccaro D |title=SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. |journal=Mol. Cell |volume=23 |issue= 3 |pages= 319–29 |year= 2006 |pmid= 16885022 |doi= 10.1016/j.molcel.2006.06.013 |display-authors=etal}}
*{{cite journal  | author=Bennett LN, Clarke PR |title=Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation. |journal=FEBS Lett. |volume=580 |issue= 17 |pages= 4176-81 |year= 2006 |pmid= 16828751 |doi= 10.1016/j.febslet.2006.06.071 }}
*{{cite journal  | vauthors=Mamely I, van Vugt MA, Smits VA |title=Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. |journal=Curr. Biol. |volume=16 |issue= 19 |pages= 1950–5 |year= 2006 |pmid= 16934469 |doi= 10.1016/j.cub.2006.08.026 |display-authors=etal}}
*{{cite journal  | author=Liu S, Bekker-Jensen S, Mailand N, ''et al.'' |title=Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. |journal=Mol. Cell. Biol. |volume=26 |issue= 16 |pages= 6056-64 |year= 2006 |pmid= 16880517 |doi= 10.1128/MCB.00492-06 }}
*{{cite journal  | vauthors=Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R |title=Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8672–9 |year= 2007 |pmid= 16951182 |doi= 10.1158/0008-5472.CAN-05-4443 |display-authors=etal}}
*{{cite journal  | author=Mailand N, Bekker-Jensen S, Bartek J, Lukas J |title=Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. |journal=Mol. Cell |volume=23 |issue= 3 |pages= 307-18 |year= 2006 |pmid= 16885021 |doi= 10.1016/j.molcel.2006.06.016 }}
*{{cite journal  | vauthors=Chini CC, Chen J |title=Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. |journal=J. Biol. Chem. |volume=281 |issue= 44 |pages= 33276–82 |year= 2006 |pmid= 16963448 |doi= 10.1074/jbc.M604373200 }}
*{{cite journal  | author=Peschiaroli A, Dorrello NV, Guardavaccaro D, ''et al.'' |title=SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. |journal=Mol. Cell |volume=23 |issue= 3 |pages= 319-29 |year= 2006 |pmid= 16885022 |doi= 10.1016/j.molcel.2006.06.013 }}
*{{cite journal  | vauthors=Sercin O, Kemp MG | title=Characterization of functional domains in human Claspin.
*{{cite journal  | author=Mamely I, van Vugt MA, Smits VA, ''et al.'' |title=Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. |journal=Curr. Biol. |volume=16 |issue= 19 |pages= 1950-5 |year= 2006 |pmid= 16934469 |doi= 10.1016/j.cub.2006.08.026 }}
|journal=Cell Cycle |volume=10 |issue= 10 |pages= 1599–606 |year= 2011|pmid= 21478680  |doi= 10.4161/cc.10.10.15562 |pmc=3127160}}
*{{cite journal  | author=Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, ''et al.'' |title=Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8672-9 |year= 2007 |pmid= 16951182 |doi= 10.1158/0008-5472.CAN-05-4443 }}
*{{cite journal  | author=Chini CC, Chen J |title=Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. |journal=J. Biol. Chem. |volume=281 |issue= 44 |pages= 33276-82 |year= 2006 |pmid= 16963448 |doi= 10.1074/jbc.M604373200 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 09:50, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Claspin is a protein that in humans is encoded by the CLSPN gene.[1][2][3]

Function

Xenopus claspin is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.[3]

Interactions

CLSPN has been shown to interact with:

References

  1. ↑ Kumagai A, Dunphy WG (Nov 2000). "Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts". Mol Cell. 6 (4): 839–49. doi:10.1016/S1097-2765(05)00092-4. PMID 11090622.
  2. ↑ 2.0 2.1 Chini CC, Chen J (Aug 2003). "Human claspin is required for replication checkpoint control". J Biol Chem. 278 (32): 30057–62. doi:10.1074/jbc.M301136200. PMID 12766152.
  3. ↑ 3.0 3.1 "Entrez Gene: CLSPN claspin homolog (Xenopus laevis)".
  4. ↑ Lin SY, Li K, Stewart GS, Elledge SJ (2004). "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation". Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6484–9. doi:10.1073/pnas.0401847101. PMC 404071. PMID 15096610.
  5. ↑ 5.0 5.1 5.2 Serçin O, Kemp MG (May 2011). "Characterization of functional domains in human Claspin". Cell Cycle. 10 (10): 1599–606. doi:10.4161/cc.10.10.15562. PMC 3127160. PMID 21478680.
  6. ↑ Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N (2009). "USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin". J. Cell Biol. 184 (1): 13–9. doi:10.1083/jcb.200807137. PMC 2615094. PMID 19124652.

External links

Further reading


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