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{{ | '''Phospholipase A2, membrane associated''' is an [[enzyme]] that in humans is encoded by the ''PLA2G2A'' [[gene]].<ref name="pmid8838795">{{cite journal |vauthors=Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ | title = Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human | journal = Genomics | volume = 32 | issue = 3 | pages = 328–33 |date=Feb 1997 | pmid = 8838795 | pmc = | doi = 10.1006/geno.1996.0126 }}</ref><ref>{{cite web | title = Entrez Gene: PLA2G2A Phospholipase A2, group IIA (platelets, synovial fluid)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5320| accessdate = }}</ref> | ||
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==See also== | ==See also== | ||
*[[Phospholipase A2]] | *[[Phospholipase A2]] | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
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| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Kramer RM, Johansen B, Hession C, Pepinsky RB |title=Structure and properties of a secretable phospholipase A2 from human platelets. |journal=Adv. Exp. Med. Biol. |volume=275 |issue= |pages= 35–53 |year= 1990 |pmid= 2239446 |doi= 10.1007/978-1-4684-5805-3_3}} | ||
*{{cite journal | author=Schröder HC | *{{cite journal | author=Schröder HC |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death |journal=Neurotoxicology |volume=19 |issue= 4–5 |pages= 683–8 |year= 1998 |pmid= 9745929 |doi= |name-list-format=vanc| author2=Perovic S | author3=Kavsan V | display-authors=3 | last4=Ushijima | first4=H | last5=Müller | first5=WE }} | ||
*{{cite journal |vauthors=Law MH, Cotton RG, Berger GE |title=The role of phospholipases A2 in schizophrenia |journal=Mol. Psychiatry |volume=11 |issue= 6 |pages= 547–56 |year= 2006 |pmid= 16585943 |doi= 10.1038/sj.mp.4001819 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Carlquist JF, Muhlestein JB, Anderson JL |title=Lipoprotein-associated phospholipase A2: a new biomarker for cardiovascular risk assessment and potential therapeutic target |journal=Expert Rev. Mol. Diagn. |volume=7 |issue= 5 |pages= 511–7 |year= 2007 |pmid= 17892360 |doi= 10.1586/14737159.7.5.511 }} | ||
*{{cite journal | | *{{cite journal | author=Scott DL |title=Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate |journal=Science |volume=254 |issue= 5034 |pages= 1007–10 |year= 1991 |pmid= 1948070 |doi=10.1126/science.1948070 |name-list-format=vanc| author2=White SP | author3=Browning JL | display-authors=3 | last4=Rosa | first4=J. | last5=Gelb | first5=M. | last6=Sigler | first6=P. }} | ||
*{{cite journal | author=Pruzanski W |title=Enzymatic activity and distribution of phospholipase A2 in human cartilage |journal=Life Sci. |volume=48 |issue= 25 |pages= 2457–62 |year= 1991 |pmid= 2046470 |doi=10.1016/0024-3205(91)90381-K |name-list-format=vanc| author2=Bogoch E | author3=Stefanski E | display-authors=3 | last4=Wloch | first4=M. | last5=Vadas | first5=P. }} | |||
*{{cite journal | author=Wery JP |title=Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution |journal=Nature |volume=352 |issue= 6330 |pages= 79–82 |year= 1991 |pmid= 2062381 |doi= 10.1038/352079a0 |name-list-format=vanc| author2=Schevitz RW | author3=Clawson DK | display-authors=3 | last4=Bobbitt | first4=J. L | last5=Dow | first5=E. R | last6=Gamboa | first6=G | last7=Goodson Jr | first7=T | last8=Hermann | first8=R. B | last9=Kramer | first9=R. M }} | |||
*{{cite journal | author= | *{{cite journal | author=Seilhamer JJ |title=Novel gene exon homologous to pancreatic phospholipase A2: sequence and chromosomal mapping of both human genes |journal=J. Cell. Biochem. |volume=39 |issue= 3 |pages= 327–37 |year= 1989 |pmid= 2708461 |doi= 10.1002/jcb.240390312 |name-list-format=vanc| author2=Randall TL | author3=Johnson LK | display-authors=3 | last4=Heinzmann | first4=C. | last5=Klisak | first5=I. | last6=Sparkes | first6=R. S. | last7=Lusis | first7=A. J. }} | ||
*{{cite journal | author=Kanda A |title=The primary structure of a membrane-associated phospholipase A2 from human spleen |journal=Biochem. Biophys. Res. Commun. |volume=163 |issue= 1 |pages= 42–8 |year= 1989 |pmid= 2775276 |doi=10.1016/0006-291X(89)92096-2 |name-list-format=vanc| author2=Ono T | author3=Yoshida N | display-authors=3 | last4=Tojo | first4=Hiromasa | last5=Okamoto | first5=Mitsuhiro }} | |||
*{{cite journal | author= | *{{cite journal | author=Seilhamer JJ |title=Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid |journal=J. Biol. Chem. |volume=264 |issue= 10 |pages= 5335–8 |year= 1989 |pmid= 2925608 |doi= |name-list-format=vanc| author2=Pruzanski W | author3=Vadas P | display-authors=3 | last4=Plant | first4=S | last5=Miller | first5=JA | last6=Kloss | first6=J | last7=Johnson | first7=LK }} | ||
*{{cite journal | author=Kramer RM |title=Structure and properties of a human non-pancreatic phospholipase A2 |journal=J. Biol. Chem. |volume=264 |issue= 10 |pages= 5768–75 |year= 1989 |pmid= 2925633 |doi= |name-list-format=vanc| author2=Hession C | author3=Johansen B | display-authors=3 | last4=Hayes | first4=G | last5=McGray | first5=P | last6=Chow | first6=EP | last7=Tizard | first7=R | last8=Pepinsky | first8=RB }} | |||
*{{cite journal | author= | *{{cite journal |vauthors=Lai CY, Wada K |title=Phospholipase A2 from human synovial fluid: purification and structural homology to the placental enzyme |journal=Biochem. Biophys. Res. Commun. |volume=157 |issue= 2 |pages= 488–93 |year= 1989 |pmid= 3202859 |doi=10.1016/S0006-291X(88)80275-4 }} | ||
*{{cite journal | author=Hara S |title=Amino acid composition and NH2-terminal amino acid sequence of human phospholipase A2 purified from rheumatoid synovial fluid |journal=J. Biochem. |volume=104 |issue= 3 |pages= 326–8 |year= 1989 |pmid= 3240982 |doi= |name-list-format=vanc| author2=Kudo I | author3=Matsuta K | display-authors=3 | last4=Miyamoto | first4=T | last5=Inoue | first5=K }} | |||
*{{cite journal | author= | *{{cite journal | author=Schevitz RW |title=Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2 |journal=Nat. Struct. Biol. |volume=2 |issue= 6 |pages= 458–65 |year= 1995 |pmid= 7664108 |doi=10.1038/nsb0695-458 |name-list-format=vanc| author2=Bach NJ | author3=Carlson DG | display-authors=3 | last4=Chirgadze | first4=N.Y. | last5=Clawson | first5=D.K. | last6=Dillard | first6=R.D. | last7=Draheim | first7=S.E. | last8=Hartley | first8=L.W. | last9=Jones | first9=N.D. }} | ||
*{{cite journal |vauthors=Ancian P, Lambeau G, Mattéi MG, Lazdunski M |title=The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization |journal=J. Biol. Chem. |volume=270 |issue= 15 |pages= 8963–70 |year= 1995 |pmid= 7721806 |doi= 10.1074/jbc.270.15.8963}} | |||
*{{cite journal | author= | *{{cite journal | author=MacPhee M |title=The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia |journal=Cell |volume=81 |issue= 6 |pages= 957–66 |year= 1995 |pmid= 7781071 |doi=10.1016/0092-8674(95)90015-2 |name-list-format=vanc| author2=Chepenik KP | author3=Liddell RA | display-authors=3 | last4=Nelson | first4=Kelly K | last5=Siracusa | first5=Linda D | last6=Buchberg | first6=Arthur M }} | ||
*{{cite journal | author=Minami T |title=Purification and characterization of a phospholipase A2 from human ileal mucosa |journal=Biochim. Biophys. Acta |volume=1170 |issue= 2 |pages= 125–30 |year= 1993 |pmid= 8399335 |doi= 10.1016/0005-2760(93)90061-d|name-list-format=vanc| author2=Tojo H | author3=Shinomura Y | display-authors=3 | last4=Matsuzawa | first4=Y | last5=Okamoto | first5=M }} | |||
*{{cite journal | author=Sartipy P |title=Binding of human phospholipase A2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity |journal=J. Biol. Chem. |volume=271 |issue= 42 |pages= 26307–14 |year= 1996 |pmid= 8824283 |doi=10.1074/jbc.271.42.26307 |name-list-format=vanc| author2=Johansen B | author3=Camejo G | display-authors=3 | last4=Rosengren | first4=B | last5=Bondjers | first5=G | last6=Hurt-Camejo | first6=E }} | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Species | Human | Mouse | |||||
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Ensembl |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
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Phospholipase A2, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene.[1][2]
See also
References
- ↑ Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ (Feb 1997). "Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human". Genomics. 32 (3): 328–33. doi:10.1006/geno.1996.0126. PMID 8838795.
- ↑ "Entrez Gene: PLA2G2A Phospholipase A2, group IIA (platelets, synovial fluid)".
Further reading
- Kramer RM, Johansen B, Hession C, Pepinsky RB (1990). "Structure and properties of a secretable phospholipase A2 from human platelets". Adv. Exp. Med. Biol. 275: 35–53. doi:10.1007/978-1-4684-5805-3_3. PMID 2239446.
- Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
- Law MH, Cotton RG, Berger GE (2006). "The role of phospholipases A2 in schizophrenia". Mol. Psychiatry. 11 (6): 547–56. doi:10.1038/sj.mp.4001819. PMID 16585943.
- Carlquist JF, Muhlestein JB, Anderson JL (2007). "Lipoprotein-associated phospholipase A2: a new biomarker for cardiovascular risk assessment and potential therapeutic target". Expert Rev. Mol. Diagn. 7 (5): 511–7. doi:10.1586/14737159.7.5.511. PMID 17892360.
- Scott DL, White SP, Browning JL, et al. (1991). "Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate". Science. 254 (5034): 1007–10. doi:10.1126/science.1948070. PMID 1948070.
- Pruzanski W, Bogoch E, Stefanski E, et al. (1991). "Enzymatic activity and distribution of phospholipase A2 in human cartilage". Life Sci. 48 (25): 2457–62. doi:10.1016/0024-3205(91)90381-K. PMID 2046470.
- Wery JP, Schevitz RW, Clawson DK, et al. (1991). "Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution". Nature. 352 (6330): 79–82. doi:10.1038/352079a0. PMID 2062381.
- Seilhamer JJ, Randall TL, Johnson LK, et al. (1989). "Novel gene exon homologous to pancreatic phospholipase A2: sequence and chromosomal mapping of both human genes". J. Cell. Biochem. 39 (3): 327–37. doi:10.1002/jcb.240390312. PMID 2708461.
- Kanda A, Ono T, Yoshida N, et al. (1989). "The primary structure of a membrane-associated phospholipase A2 from human spleen". Biochem. Biophys. Res. Commun. 163 (1): 42–8. doi:10.1016/0006-291X(89)92096-2. PMID 2775276.
- Seilhamer JJ, Pruzanski W, Vadas P, et al. (1989). "Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid". J. Biol. Chem. 264 (10): 5335–8. PMID 2925608.
- Kramer RM, Hession C, Johansen B, et al. (1989). "Structure and properties of a human non-pancreatic phospholipase A2". J. Biol. Chem. 264 (10): 5768–75. PMID 2925633.
- Lai CY, Wada K (1989). "Phospholipase A2 from human synovial fluid: purification and structural homology to the placental enzyme". Biochem. Biophys. Res. Commun. 157 (2): 488–93. doi:10.1016/S0006-291X(88)80275-4. PMID 3202859.
- Hara S, Kudo I, Matsuta K, et al. (1989). "Amino acid composition and NH2-terminal amino acid sequence of human phospholipase A2 purified from rheumatoid synovial fluid". J. Biochem. 104 (3): 326–8. PMID 3240982.
- Schevitz RW, Bach NJ, Carlson DG, et al. (1995). "Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2". Nat. Struct. Biol. 2 (6): 458–65. doi:10.1038/nsb0695-458. PMID 7664108.
- Ancian P, Lambeau G, Mattéi MG, Lazdunski M (1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". J. Biol. Chem. 270 (15): 8963–70. doi:10.1074/jbc.270.15.8963. PMID 7721806.
- MacPhee M, Chepenik KP, Liddell RA, et al. (1995). "The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia". Cell. 81 (6): 957–66. doi:10.1016/0092-8674(95)90015-2. PMID 7781071.
- Minami T, Tojo H, Shinomura Y, et al. (1993). "Purification and characterization of a phospholipase A2 from human ileal mucosa". Biochim. Biophys. Acta. 1170 (2): 125–30. doi:10.1016/0005-2760(93)90061-d. PMID 8399335.
- Sartipy P, Johansen B, Camejo G, et al. (1996). "Binding of human phospholipase A2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity". J. Biol. Chem. 271 (42): 26307–14. doi:10.1074/jbc.271.42.26307. PMID 8824283.
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