Flavin containing monooxygenase 1: Difference between revisions

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{{Infobox_gene}}
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'''Dimethylaniline monooxygenase [N-oxide-forming] 1''' is an [[enzyme]] that in humans is encoded by the ''FMO1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FMO1 flavin containing monooxygenase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2326| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Flavin containing monooxygenase 1
| HGNCid = 3769
| Symbol = FMO1
| AltSymbols =;
| OMIM = 136130
| ECnumber = 
| Homologene = 55520
| MGIid = 1310002
| GeneAtlas_image1 = PBB_GE_FMO1_205666_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004499 |text = flavin-containing monooxygenase activity}} {{GNF_GO|id=GO:0015036 |text = disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0050660 |text = FAD binding}} {{GNF_GO|id=GO:0050661 |text = NADP binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0031227 |text = intrinsic to endoplasmic reticulum membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2326
    | Hs_Ensembl = ENSG00000010932
    | Hs_RefseqProtein = NP_002012
    | Hs_RefseqmRNA = NM_002021
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 169484262
    | Hs_GenLoc_end = 169521741
    | Hs_Uniprot = Q01740
    | Mm_EntrezGene = 14261
    | Mm_Ensembl = ENSMUSG00000040181
    | Mm_RefseqmRNA = NM_010231
    | Mm_RefseqProtein = NP_034361
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 164666232
    | Mm_GenLoc_end = 164703223
    | Mm_Uniprot = Q3UNX7
  }}
}}
'''Flavin containing monooxygenase 1''', also known as '''FMO1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FMO1 flavin containing monooxygenase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2326| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region.  Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.<ref name="entrez">{{cite web | title = Entrez Gene: FMO1 flavin containing monooxygenase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2326| accessdate = }}</ref>
| summary_text = Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region.  Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in xenobiotics such as pesticides and drugs.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hines RN, Cashman JR, Philpot RM, ''et al.'' |title=The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. |journal=Toxicol. Appl. Pharmacol. |volume=125 |issue= 1 |pages= 1-6 |year= 1994 |pmid= 8128486 |doi= 10.1006/taap.1994.1042 }}
*{{cite journal  | author=Hines RN |title=The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression |journal=Toxicol. Appl. Pharmacol. |volume=125 |issue= 1 |pages= 1–6 |year= 1994 |pmid= 8128486 |doi= 10.1006/taap.1994.1042  |name-list-format=vanc| author2=Cashman JR | author3=Philpot RM  | display-authors=3  | last4=Williams  | first4=DE  | last5=Ziegler  | first5=DM }}
*{{cite journal | author=Cashman JR |title=The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development. |journal=Drug Discov. Today |volume=9 |issue= 13 |pages= 574-81 |year= 2004 |pmid= 15203093 |doi= 10.1016/S1359-6446(04)03136-8 }}
*{{cite journal  | author=Cashman JR |title=The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development |journal=Drug Discov. Today |volume=9 |issue= 13 |pages= 574–581 |year= 2004 |pmid= 15203093 |doi= 10.1016/S1359-6446(04)03136-8 }}
*{{cite journal  | author=Dolphin C, Shephard EA, Povey S, ''et al.'' |title=Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1). |journal=J. Biol. Chem. |volume=266 |issue= 19 |pages= 12379-85 |year= 1991 |pmid= 1712018 |doi=  }}
*{{cite journal  | author=Dolphin C |title=Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1) |journal=J. Biol. Chem. |volume=266 |issue= 19 |pages= 12379–85 |year= 1991 |pmid= 1712018 |doi=  |name-list-format=vanc| author2=Shephard EA | author3=Povey S  | display-authors=3  | last4=Palmer  | first4=CN  | last5=Ziegler  | first5=DM  | last6=Ayesh  | first6=R  | last7=Smith  | first7=RL  | last8=Phillips  | first8=IR }}
*{{cite journal | author=Phillips IR, Dolphin CT, Clair P, ''et al.'' |title=The molecular biology of the flavin-containing monooxygenases of man. |journal=Chem. Biol. Interact. |volume=96 |issue= 1 |pages= 17-32 |year= 1995 |pmid= 7720101 |doi=  }}
*{{cite journal  | author=Phillips IR |title=The molecular biology of the flavin-containing monooxygenases of man |journal=Chem. Biol. Interact. |volume=96 |issue= 1 |pages= 17–32 |year= 1995 |pmid= 7720101 |doi=10.1016/0009-2797(94)03580-2 |name-list-format=vanc| author2=Dolphin CT | author3=Clair P  | display-authors=3  | last4=Hadley  | first4=MR  | last5=Hutt  | first5=AJ  | last6=McCombie  | first6=RR  | last7=Smith  | first7=RL  | last8=Shephard  | first8=EA  }}
*{{cite journal  | author=Lawton MP, Cashman JR, Cresteil T, ''et al.'' |title=A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. |journal=Arch. Biochem. Biophys. |volume=308 |issue= 1 |pages= 254-7 |year= 1994 |pmid= 8311461 |doi=  }}
*{{cite journal  | author=Lawton MP |title=A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities |journal=Arch. Biochem. Biophys. |volume=308 |issue= 1 |pages= 254–257 |year= 1994 |pmid= 8311461 |doi=10.1006/abbi.1994.1035 |name-list-format=vanc| author2=Cashman JR | author3=Cresteil T  | display-authors=3  | last4=Dolphin  | first4=CT  | last5=Elfarra  | first5=AA  | last6=Hines  | first6=RN  | last7=Hodgson  | first7=E  | last8=Kimura  | first8=T  | last9=Ozols  | first9=J }}
*{{cite journal  | author=Shephard EA, Dolphin CT, Fox MF, ''et al.'' |title=Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q. |journal=Genomics |volume=16 |issue= 1 |pages= 85-9 |year= 1993 |pmid= 8486388 |doi= 10.1006/geno.1993.1144 }}
*{{cite journal  | author=Shephard EA |title=Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q |journal=Genomics |volume=16 |issue= 1 |pages= 85–89 |year= 1993 |pmid= 8486388 |doi= 10.1006/geno.1993.1144 |name-list-format=vanc| author2=Dolphin CT  | author3=Fox MF  | display-authors=3 | last4=Povey  | first4=S  | last5=Smith  | first5=R  | last6=Phillips  | first6=IR }}
*{{cite journal  | author=Hay JC, Chao DS, Kuo CS, Scheller RH |title=Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. |journal=Cell |volume=89 |issue= 1 |pages= 149-58 |year= 1997 |pmid= 9094723 |doi=  }}
*{{cite journal  |vauthors=Hay JC, Chao DS, Kuo CS, Scheller RH |title=Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells |journal=Cell |volume=89 |issue= 1 |pages= 149–158 |year= 1997 |pmid= 9094723 |doi=10.1016/S0092-8674(00)80191-9  }}
*{{cite journal | author=Yeung CK, Lang DH, Thummel KE, Rettie AE |title=Immunoquantitation of FMO1 in human liver, kidney, and intestine. |journal=Drug Metab. Dispos. |volume=28 |issue= 9 |pages= 1107-11 |year= 2000 |pmid= 10950857 |doi=  }}
*{{cite journal  |vauthors=Yeung CK, Lang DH, Thummel KE, Rettie AE |title=Immunoquantitation of FMO1 in human liver, kidney, and intestine |journal=Drug Metab. Dispos. |volume=28 |issue= 9 |pages= 1107–11 |year= 2000 |pmid= 10950857 |doi=  }}
*{{cite journal  | author=Washio T, Arisawa H, Kohsaka K, Yasuda H |title=Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011. |journal=Biol. Pharm. Bull. |volume=24 |issue= 11 |pages= 1263-6 |year= 2002 |pmid= 11725960 |doi=  }}
*{{cite journal  |vauthors=Washio T, Arisawa H, Kohsaka K, Yasuda H |title=Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011 |journal=Biol. Pharm. Bull. |volume=24 |issue= 11 |pages= 1263–1266 |year= 2002 |pmid= 11725960 |doi=10.1248/bpb.24.1263 }}
*{{cite journal  | author=Koukouritaki SB, Simpson P, Yeung CK, ''et al.'' |title=Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression. |journal=Pediatr. Res. |volume=51 |issue= 2 |pages= 236-43 |year= 2002 |pmid= 11809920 |doi=  }}
*{{cite journal  | author=Koukouritaki SB |title=Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression |journal=Pediatr. Res. |volume=51 |issue= 2 |pages= 236–243 |year= 2002 |pmid= 11809920 |doi=10.1203/00006450-200202000-00018  |name-list-format=vanc| author2=Simpson P  | author3=Yeung CK  | display-authors=3  | last4=Rettie  | first4=Allan E.  | last5=Hines  | first5=Ronald N. }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Furnes B, Feng J, Sommer SS, Schlenk D |title=Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. |journal=Drug Metab. Dispos. |volume=31 |issue= 2 |pages= 187-93 |year= 2003 |pmid= 12527699 |doi=  }}
*{{cite journal  |vauthors=Furnes B, Feng J, Sommer SS, Schlenk D |title=Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans |journal=Drug Metab. Dispos. |volume=31 |issue= 2 |pages= 187–193 |year= 2003 |pmid= 12527699 |doi=10.1124/dmd.31.2.187  }}
*{{cite journal  | author=Attar M, Dong D, Ling KH, Tang-Liu DD |title=Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans. |journal=Drug Metab. Dispos. |volume=31 |issue= 4 |pages= 476-81 |year= 2003 |pmid= 12642475 |doi=  }}
*{{cite journal  |vauthors=Attar M, Dong D, Ling KH, Tang-Liu DD |title=Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans |journal=Drug Metab. Dispos. |volume=31 |issue= 4 |pages= 476–481 |year= 2003 |pmid= 12642475 |doi=10.1124/dmd.31.4.476  }}
*{{cite journal  | author=Hines RN, Luo Z, Hopp KA, ''et al.'' |title=Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6). |journal=J. Pharmacol. Exp. Ther. |volume=306 |issue= 3 |pages= 1210-8 |year= 2003 |pmid= 12829732 |doi= 10.1124/jpet.103.053686 }}
*{{cite journal  | author=Hines RN |title=Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6) |journal=J. Pharmacol. Exp. Ther. |volume=306 |issue= 3 |pages= 1210–1218 |year= 2003 |pmid= 12829732 |doi= 10.1124/jpet.103.053686  |name-list-format=vanc| author2=Luo Z  | author3=Hopp KA  | display-authors=3  | last4=Cabacungan  | first4=ET  | last5=Koukouritaki  | first5=SB  | last6=McCarver  | first6=DG }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Zhang J, Cashman JR |title=Quantitative analysis of FMO gene mRNA levels in human tissues. |journal=Drug Metab. Dispos. |volume=34 |issue= 1 |pages= 19-26 |year= 2006 |pmid= 16183778 |doi= 10.1124/dmd.105.006171 }}
*{{cite journal  |vauthors=Zhang J, Cashman JR |title=Quantitative analysis of FMO gene mRNA levels in human tissues |journal=Drug Metab. Dispos. |volume=34 |issue= 1 |pages= 19–26 |year= 2006 |pmid= 16183778 |doi= 10.1124/dmd.105.006171 }}
*{{cite journal | author=Bartsch M, Gobbato E, Bednarek P, ''et al.'' |title=Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7. |journal=Plant Cell |volume=18 |issue= 4 |pages= 1038-51 |year= 2006 |pmid= 16531493 |doi= 10.1105/tpc.105.039982 }}
*{{cite journal  | author=Bartsch M |title=Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7 |journal=Plant Cell |volume=18 |issue= 4 |pages= 1038–1051 |year= 2006 |pmid= 16531493 |doi= 10.1105/tpc.105.039982  | pmc=1425861  |name-list-format=vanc| author2=Gobbato E  | author3=Bednarek P  | display-authors=3  | last4=Debey  | first4=S  | last5=Schultze  | first5=JL  | last6=Bautor  | first6=J  | last7=Parker  | first7=JE }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 06:28, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene.[1]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in xenobiotics such as pesticides and drugs.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: FMO1 flavin containing monooxygenase 1".

Further reading



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