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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Borealin''' is a [[protein]] that in humans is encoded by the ''CDCA8'' [[gene]].<ref name="pmid12188893">{{cite journal | vauthors = Walker MG | title = Drug target discovery by gene expression analysis: cell cycle genes | journal = Current Cancer Drug Targets | volume = 1 | issue = 1 | pages = 73–83 | date = May 2001 | pmid = 12188893 | pmc =  | doi = 10.2174/1568009013334241 }}</ref><ref name="Sampath_2004">{{cite journal | vauthors = Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H | title = The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly | journal = Cell | volume = 118 | issue = 2 | pages = 187–202 | date = Jul 2004 | pmid = 15260989 | pmc = | doi = 10.1016/j.cell.2004.06.026 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDCA8 cell division cycle associated 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55143| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cell division cycle associated 8
| HGNCid = 14629
| Symbol = CDCA8
| AltSymbols =; BOR; FLJ10468; FLJ12042
| OMIM = 609977
| ECnumber = 
| Homologene = 23075
| MGIid = 1196274
| GeneAtlas_image1 = PBB_GE_CDCA8_221520_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000775 |text = chromosome, pericentric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55143
    | Hs_Ensembl = ENSG00000134690
    | Hs_RefseqProtein = NP_060571
    | Hs_RefseqmRNA = NM_018101
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 37930677
    | Hs_GenLoc_end = 37947978
    | Hs_Uniprot = Q53HL2
    | Mm_EntrezGene = 52276
    | Mm_Ensembl = ENSMUSG00000028873
    | Mm_RefseqmRNA = NM_026560
    | Mm_RefseqProtein = NP_080836
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 124420769
    | Mm_GenLoc_end = 124439207
    | Mm_Uniprot = Q8BHX3
  }}
}}
'''Cell division cycle associated 8''', also known as '''CDCA8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDCA8 cell division cycle associated 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55143| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.<ref name="entrez" /><ref name = "Gassman_2004">{{cite journal | vauthors = Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC | title = Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle | journal = The Journal of Cell Biology | volume = 166 | issue = 2 | pages = 179–91 | date = Jul 2004 | pmid = 15249581 | doi = 10.1083/jcb.200404001 | pmc=2172304}}</ref>
{{PBB_Summary
| section_title =
| summary_text = CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle (Gassmann et al., 2004).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CDCA8 cell division cycle associated 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55143| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CDCA8 has been shown to [[Protein-protein interaction|interact]] with [[INCENP]],<ref name = "Gassman_2004"/> [[Survivin]]<ref name="Sampath_2004"/><ref name = "Gassman_2004"/> and [[Aurora B kinase]].<ref name="Sampath_2004"/><ref name = "Gassman_2004"/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4  | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56  | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH | title = Proteome analysis of the human mitotic spindle | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 1 | pages = 35–43  | date = Jan 2005 | pmid = 15561729 | doi = 10.1074/mcp.M400158-MCP200 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83  | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal  | author=Walker MG |title=Drug target discovery by gene expression analysis: cell cycle genes. |journal=Current cancer drug targets |volume=1 |issue= 1 |pages= 73-83 |year= 2002 |pmid= 12188893 |doi=  }}
* {{cite journal | vauthors = Vader G, Kauw JJ, Medema RH, Lens SM | title = Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody | journal = EMBO Reports | volume = 7 | issue = 1 | pages = 85–92  | date = Jan 2006 | pmid = 16239925 | pmc = 1369225 | doi = 10.1038/sj.embor.7400562 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP | title = Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis | journal = The Journal of Biological Chemistry | volume = 281 | issue = 2 | pages = 1286–95  | date = Jan 2006 | pmid = 16291752 | doi = 10.1074/jbc.M508773200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM | title = Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer | journal = Experimental Cell Research | volume = 312 | issue = 7 | pages = 962–73  | date = Apr 2006 | pmid = 16427043 | doi = 10.1016/j.yexcr.2005.12.015 }}
*{{cite journal  | author=Gassmann R, Carvalho A, Henzing AJ, ''et al.'' |title=Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. |journal=J. Cell Biol. |volume=166 |issue= 2 |pages= 179-91 |year= 2004 |pmid= 15249581 |doi= 10.1083/jcb.200404001 }}
* {{cite journal | vauthors = Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH | title = Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres | journal = Molecular Biology of the Cell | volume = 17 | issue = 4 | pages = 1897–909  | date = Apr 2006 | pmid = 16436504 | pmc = 1415303 | doi = 10.1091/mbc.E05-08-0727 }}
*{{cite journal  | author=Sampath SC, Ohi R, Leismann O, ''et al.'' |title=The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. |journal=Cell |volume=118 |issue= 2 |pages= 187-202 |year= 2004 |pmid= 15260989 |doi= 10.1016/j.cell.2004.06.026 }}
* {{cite journal | vauthors = Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G | title = Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown | journal = Oncogene | volume = 25 | issue = 35 | pages = 4867–79  | date = Aug 2006 | pmid = 16547492 | doi = 10.1038/sj.onc.1209499 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6  | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Sauer G, Körner R, Hanisch A, ''et al.'' |title=Proteome analysis of the human mitotic spindle. |journal=Mol. Cell Proteomics |volume=4 |issue= 1 |pages= 35-43 |year= 2005 |pmid= 15561729 |doi= 10.1074/mcp.M400158-MCP200 }}
* {{cite journal | vauthors = Klein UR, Nigg EA, Gruneberg U | title = Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP | journal = Molecular Biology of the Cell | volume = 17 | issue = 6 | pages = 2547–58  | date = Jun 2006 | pmid = 16571674 | pmc = 1474794 | doi = 10.1091/mbc.E05-12-1133 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
* {{cite journal | vauthors = Kaur H, Stiff AC, Date DA, Taylor WR | title = Analysis of mitotic phosphorylation of borealin | journal = BMC Cell Biology | volume = 8 | pages = 5 | year = 2007 | pmid = 17241471 | pmc = 1794407 | doi = 10.1186/1471-2121-8-5 }}
*{{cite journal | author=Vader G, Kauw JJ, Medema RH, Lens SM |title=Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. |journal=EMBO Rep. |volume=7 |issue= 1 |pages= 85-92 |year= 2006 |pmid= 16239925 |doi= 10.1038/sj.embor.7400562 }}
* {{cite journal | vauthors = Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y | title = Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis | journal = Cancer Research | volume = 67 | issue = 9 | pages = 4113–22  | date = May 2007 | pmid = 17483322 | doi = 10.1158/0008-5472.CAN-06-4705 }}
*{{cite journal | author=Noton EA, Colnaghi R, Tate S, ''et al.'' |title=Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 1286-95 |year= 2006 |pmid= 16291752 |doi= 10.1074/jbc.M508773200 }}
*{{cite journal | author=Chang JL, Chen TH, Wang CF, ''et al.'' |title=Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. |journal=Exp. Cell Res. |volume=312 |issue= 7 |pages= 962-73 |year= 2006 |pmid= 16427043 |doi= 10.1016/j.yexcr.2005.12.015 }}
*{{cite journal | author=Lens SM, Rodriguez JA, Vader G, ''et al.'' |title=Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres. |journal=Mol. Biol. Cell |volume=17 |issue= 4 |pages= 1897-909 |year= 2006 |pmid= 16436504 |doi= 10.1091/mbc.E05-08-0727 }}
*{{cite journal | author=Rodriguez JA, Lens SM, Span SW, ''et al.'' |title=Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown. |journal=Oncogene |volume=25 |issue= 35 |pages= 4867-79 |year= 2006 |pmid= 16547492 |doi= 10.1038/sj.onc.1209499 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Klein UR, Nigg EA, Gruneberg U |title=Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2547-58 |year= 2006 |pmid= 16571674 |doi= 10.1091/mbc.E05-12-1133 }}
*{{cite journal | author=Kaur H, Stiff AC, Date DA, Taylor WR |title=Analysis of mitotic phosphorylation of borealin. |journal=BMC Cell Biol. |volume=8 |issue=  |pages= 5 |year= 2007 |pmid= 17241471 |doi= 10.1186/1471-2121-8-5 }}
*{{cite journal | author=Hayama S, Daigo Y, Yamabuki T, ''et al.'' |title=Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis. |journal=Cancer Res. |volume=67 |issue= 9 |pages= 4113-22 |year= 2007 |pmid= 17483322 |doi= 10.1158/0008-5472.CAN-06-4705 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|CDCA8}}
{{gene-1-stub}}

Latest revision as of 09:27, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Borealin is a protein that in humans is encoded by the CDCA8 gene.[1][2][3]

Function

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[3][4]

Interactions

CDCA8 has been shown to interact with INCENP,[4] Survivin[2][4] and Aurora B kinase.[2][4]

References

  1. ↑ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  2. ↑ 2.0 2.1 2.2 Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
  3. ↑ 3.0 3.1 "Entrez Gene: CDCA8 cell division cycle associated 8".
  4. ↑ 4.0 4.1 4.2 4.3 Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=CDCA8&oldid=1411071"