WDR8: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''WD repeat-containing protein 8''' is a [[protein]] that in humans is encoded by the ''WDR8'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WDR8 WD repeat domain 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=49856| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = WD repeat domain 8
| HGNCid = 12759
| Symbol = WDR8
| AltSymbols =; FLJ20430; MGC99569
| OMIM = 606040
| ECnumber = 
| Homologene = 9857
| MGIid = 1891749
| GeneAtlas_image1 = PBB_GE_WDR8_219322_s_at_tn.png
| Function =  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 49856
    | Hs_Ensembl = ENSG00000116213
    | Hs_RefseqProtein = NP_060288
    | Hs_RefseqmRNA = NM_017818
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 3537191
    | Hs_GenLoc_end = 3556511
    | Hs_Uniprot = Q9P2S5
    | Mm_EntrezGene = 59002
    | Mm_Ensembl = ENSMUSG00000029029
    | Mm_RefseqmRNA = NM_021499
    | Mm_RefseqProtein = NP_067474
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 152986172
    | Mm_GenLoc_end = 153000618
    | Mm_Uniprot = Q3T993
  }}
}}
'''WD repeat domain 8''', also known as '''WDR8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WDR8 WD repeat domain 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=49856| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification.<ref name="entrez">{{cite web | title = Entrez Gene: WDR8 WD repeat domain 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=49856| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist|30em}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y | title = Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family | journal = Genomics | volume = 72 | issue = 3 | pages = 252–9 | date = March 2001 | pmid = 11401440 | doi = 10.1006/geno.2000.6475 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Koshizuka Y, Ikegawa S, Sano M, ''et al.'' |title=Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family. |journal=Genomics |volume=72 |issue= 3 |pages= 252-9 |year= 2001 |pmid= 11401440 |doi= 10.1006/geno.2000.6475 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:14, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.[1]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: WDR8 WD repeat domain 8".

Further reading

  • Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y (March 2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family". Genomics. 72 (3): 252–9. doi:10.1006/geno.2000.6475. PMID 11401440.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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