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{{Infobox_gene}}
{{PBB_Controls
'''Denticleless protein homolog''' is a [[protein]] that in humans is encoded by the ''DTL'' [[gene]].<ref name="pmid11278750">{{cite journal | vauthors = Cheung WM, Chu AH, Chu PW, Ip NY | title = Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation | journal = J Biol Chem | volume = 276 | issue = 20 | pages = 17083–91 | date = May 2001 | pmid = 11278750 | pmc =  | doi = 10.1074/jbc.M010802200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DTL denticleless homolog (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51514| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Denticleless homolog (Drosophila)
| HGNCid = 30288
| Symbol = DTL
| AltSymbols =; RAMP; CDT2; DCAF2; L2DTL
| OMIM = 610617
| ECnumber = 
| Homologene = 32313
| MGIid = 1924093
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51514
    | Hs_Ensembl = ENSG00000143476
    | Hs_RefseqProtein = NP_057532
    | Hs_RefseqmRNA = NM_016448
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 210275542
    | Hs_GenLoc_end = 210344971
    | Hs_Uniprot = 
    | Mm_EntrezGene = 76843
    | Mm_Ensembl = ENSMUSG00000037474
    | Mm_RefseqmRNA = NM_029766
    | Mm_RefseqProtein = NP_084042
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 193237980
    | Mm_GenLoc_end = 193276149
    | Mm_Uniprot = 
  }}
}}
'''Denticleless homolog (Drosophila)''', also known as '''DTL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DTL denticleless homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51514| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
DTL (gene) has been shown to [[Protein-protein interaction|interact]] with [[P21]].<ref name=pmid18794347>{{cite journal | vauthors = Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A | title = PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex | journal = Genes Dev. | volume = 22 | issue = 18 | pages = 2496–506 | date = Sep 2008 | pmid = 18794347 | pmc = 2546691 | doi = 10.1101/gad.1676108 }}</ref>
{{PBB_Summary
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| summary_text =  
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==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H | title = L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. | journal = Cell Cycle | volume = 5 | issue = 15 | pages = 1719–29 | year = 2007 | pmid = 16861890 | doi = 10.4161/cc.5.15.3150 }}
| citations =
* {{cite journal | vauthors = Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H | title = L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. | journal = Cell Cycle | volume = 5 | issue = 15 | pages = 1675–80 | year = 2007 | pmid = 16861906 | doi = 10.4161/cc.5.15.3149 }}
*{{cite journal | author=Cheung WM, Chu AH, Chu PW, Ip NY |title=Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17083-91 |year= 2001 |pmid= 11278750 |doi= 10.1074/jbc.M010802200 }}
* {{cite journal | vauthors = Jin J, Arias EE, Chen J, Harper JW, Walter JC | title = A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. | journal = Mol. Cell | volume = 23 | issue = 5 | pages = 709–21 | year = 2006 | pmid = 16949367 | doi = 10.1016/j.molcel.2006.08.010 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H | title = CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. | journal = Nat. Cell Biol. | volume = 8 | issue = 11 | pages = 1277–83 | year = 2006 | pmid = 17041588 | doi = 10.1038/ncb1490 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA | title = DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. | journal = Genes Dev. | volume = 20 | issue = 22 | pages = 3117–29 | year = 2006 | pmid = 17085480 | pmc = 1635147 | doi = 10.1101/gad.1482106 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
* {{cite journal | vauthors = Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC | title = Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. | journal = Cell Cycle | volume = 5 | issue = 22 | pages = 2676–87 | year = 2007 | pmid = 17106265 | doi = 10.4161/cc.5.22.3500 }}
*{{cite journal  | author=Banks D, Wu M, Higa LA, ''et al.'' |title=L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. |journal=Cell Cycle |volume=5 |issue= 15 |pages= 1719-29 |year= 2007 |pmid= 16861890 |doi= }}
*{{cite journal | author=Higa LA, Banks D, Wu M, ''et al.'' |title=L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. |journal=Cell Cycle |volume=5 |issue= 15 |pages= 1675-80 |year= 2007 |pmid= 16861906 |doi= }}
*{{cite journal | author=Jin J, Arias EE, Chen J, ''et al.'' |title=A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. |journal=Mol. Cell |volume=23 |issue= 5 |pages= 709-21 |year= 2006 |pmid= 16949367 |doi= 10.1016/j.molcel.2006.08.010 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Higa LA, Wu M, Ye T, ''et al.'' |title=CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. |journal=Nat. Cell Biol. |volume=8 |issue= 11 |pages= 1277-83 |year= 2006 |pmid= 17041588 |doi= 10.1038/ncb1490 }}
*{{cite journal | author=Sansam CL, Shepard JL, Lai K, ''et al.'' |title=DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. |journal=Genes Dev. |volume=20 |issue= 22 |pages= 3117-29 |year= 2006 |pmid= 17085480 |doi= 10.1101/gad.1482106 }}
*{{cite journal | author=Pan HW, Chou HY, Liu SH, ''et al.'' |title=Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. |journal=Cell Cycle |volume=5 |issue= 22 |pages= 2676-87 |year= 2007 |pmid= 17106265 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-1-stub}}

Latest revision as of 03:18, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.[1][2]

Interactions

DTL (gene) has been shown to interact with P21.[3]

References

  1. ↑ Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.
  2. ↑ "Entrez Gene: DTL denticleless homolog (Drosophila)".
  3. ↑ Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

Further reading

  • Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes". Cell Cycle. 5 (15): 1719–29. doi:10.4161/cc.5.15.3150. PMID 16861890.
  • Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage". Cell Cycle. 5 (15): 1675–80. doi:10.4161/cc.5.15.3149. PMID 16861906.
  • Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1". Mol. Cell. 23 (5): 709–21. doi:10.1016/j.molcel.2006.08.010. PMID 16949367.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588.
  • Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint". Genes Dev. 20 (22): 3117–29. doi:10.1101/gad.1482106. PMC 1635147. PMID 17085480.
  • Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma". Cell Cycle. 5 (22): 2676–87. doi:10.4161/cc.5.22.3500. PMID 17106265.


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